{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:07:58Z","timestamp":1793257678523,"version":"4.5.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472653"],"award-info":[{"award-number":["82472653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012173","name":"China-Japan Friendship Hospital","doi-asserted-by":"publisher","award":["2024-NHLHCRF-PYII-17"],"award-info":[{"award-number":["2024-NHLHCRF-PYII-17"]}],"id":[{"id":"10.13039\/501100012173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cervical cancer treatments, including radical hysterectomy and chemoradiotherapy, often lead to urinary, anorectal, and sexual dysfunctions. Nerve-sparing radical hysterectomy (NSRH) aims to reduce such complications, but evidence on long-term quality of life (QoL) remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare QoL outcomes in cervical cancer survivors after NSRH, conventional radical hysterectomy (CRH), or concurrent chemoradiotherapy (CCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study enrolled 427 patients (241 NSRH, 60 CRH, 126 CCR) aged \u226460 years with \u22656 months post-treatment follow-up. QoL was assessed using EORTC QLQ-C30\/CX24, Female Sexual Function Index (FSFI), and a self-reported questionnaire. Statistical analyses included ANOVA and chi-square tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Urinary symptoms occurred in 27.4% (NSRH), 40.0% (CRH), and 18.6% (CCR) (*p*=0.004). Anorectal symptoms were reported in 23.2% (NSRH), 25.0% (CRH), and 18.6% (CCR) (*p*=0.360). Among sexually active patients, FSFI total scores were higher in NSRH (23.8) vs. CRH (23.3) and CCR (21.6) (*p*=0.026). NSRH also showed superior sexual desire, arousal, and orgasm scores. QoL scores (EORTC QLQ-C30\/CX24) indicated better outcomes in constipation (*p*=0.003), lymphedema (*p*&amp;lt;0.001), and sexual activity (*p*=0.027) for NSRH. Subgroup analysis confirmed NSRH alone had fewer complications than NSRH with adjuvant radiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NSRH demonstrates significant advantages in preserving urinary, anorectal, and sexual functions, thereby improving QoL compared to CRH or CCR. It is a preferable option for early-stage cervical cancer, particularly in younger patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1654730","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T04:17:18Z","timestamp":1757391438000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Quality of life in cervical cancer survivors after nerve-sparing radical hysterectomy, conventional radical hysterectomy or concurrent 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