{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:03:19Z","timestamp":1756512199561,"version":"3.44.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Composite hemangioendothelioma (CHE) is a rare borderline vascular neoplasm, typically characterized by a heterogeneous composition of benign, intermediate, and malignant vascular elements. Metastasis occurs occasionally, yet local recurrence remains relatively common. CHE frequently manifest in the deep dermis and subcutaneous soft tissues of the distal limbs, and are rarely observed in bone or vertebral column. We present a case that originally occurred in the lumbar spine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 75-year-old male patient presented with progressively worsening pain in the lumbar and gluteal regions, accompanied by impaired mobility. Lumbar spine MRI and PET-CT imaging revealed abnormal signals in the left side of the L5 vertebral body and the left pedicle, indicative of potentially aggressive pathological changes. Pathological biopsy under general anesthesia confirmed a diagnosis of CHE. Given the impossibility of completely resecting the lesion, the patient underwent radiation therapy. After a course of radiotherapy (60Gy\/30 fractions), the patient was discharged from the hospital. The patient has been followed up for a period of 20 months with no evidence of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CHE refers to a rare type of tumor that rarely involves the spine. We present a case of CHE occurring in the L5 vertebral body. Given the lack of definitive indications for surgical intervention, radiation therapy was administered, resulting in highly satisfactory therapeutic outcomes and an excellent prognosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1656872","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T04:11:54Z","timestamp":1756440714000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A case report and literature review on positive outcomes achieved through radiotherapy in a patient with composite hemangioendothelioma"],"prefix":"10.3389","volume":"15","author":[{"given":"Fei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cha","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonglian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongting","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaofen","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200003000-00003","article-title":"Composite hemangioendothelioma: a complex, low-grade vascular lesion mimicking angiosarcoma","volume":"24","author":"Nayler","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6181","article-title":"Incidence, demographics, and survival of Malignant hemangioendothelioma in the United States","volume":"12","author":"Paulson","year":"2023","journal-title":"Cancer Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000079","article-title":"Composite hemangioendothelioma: clinical and histologic features of an enigmatic entity","volume":"22","author":"Shang Leen","year":"2015","journal-title":"Adv Anat Pathol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.3390\/jcm14082541","article-title":"Recurrence-free survival in composite hemangioendothelioma: A case study and updated systematic review","volume":"14","author":"Reljic","year":"2025","journal-title":"J Clin Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13000-023-01365-1","article-title":"Patient with composite haemangioendothelioma containing angiosarcoma-like areas in the setting of congenital lymphoedema mimicking Stewart-Treves syndrome: a case report","volume":"18","author":"Balko","year":"2023","journal-title":"Diagn Pathol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.83","article-title":"Composite hemangioendothelioma with neuroendocrine marker expression: an aggressive variant","volume":"30","author":"Perry","year":"2017","journal-title":"Mod Pathol Off J U S Can Acad Pathol Inc"},{"key":"B7","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1186\/s12877-022-03677-1","article-title":"Composite hemangioendothelioma in the cervical spine with kaposiform hemangioendothelioma features in an elderly patient: a case report","volume":"22","author":"Nakamura","year":"2022","journal-title":"BMC Geriatr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1186\/s12891-023-06745-8","article-title":"Composite hemangioendothelioma- report of two cases located in bone and review of the literature","volume":"24","author":"Deng","year":"2023","journal-title":"BMC Musculoskelet Disord"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.91.2.0308","article-title":"Recurrent intracranial Masson\u2019s vegetant intravascular hemangioendothelioma: Case report and review of the literature","volume":"91","author":"Avellino","year":"1999","journal-title":"J Neurosurg"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02366.x","article-title":"Composite cutaneous haemangioendothelioma treated with interferon","volume":"22","author":"Uta\u015f","year":"2008","journal-title":"J Eur Acad Dermatol Venereol JEADV"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e328342718d","article-title":"Composite haemangioendothelioma: report of four cases with emphasis on atypical clinical presentation","volume":"43","author":"Tsai","year":"2011","journal-title":"Pathol (Phila.)"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-012-0592-5","article-title":"Complete disappearance of uptake of FDG in the multifocal liver hemangioendothelioma after radioembolization therapy using yttrium-90 microspheres","volume":"26","author":"Karaman","year":"2012","journal-title":"Ann Nucl Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.08.044","article-title":"Composite hemangioendothelioma presenting as a scalp nodule with alopecia","volume":"69","author":"Liau","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1053\/j.jfas.2016.08.005","article-title":"Reconstruction with \u03b2-tricalcium phosphate after navicular tumor resection","volume":"56","author":"Sakamoto","year":"2017","journal-title":"J Foot Ankle Surg"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1177\/1066896920924120","article-title":"Composite hemangioendothelioma with neuroendocrine marker expression: report of a \u2018Paraganglioma-like\u2019 Paravertebral case","volume":"28","author":"Cheuk","year":"2020","journal-title":"Int J Surg Pathol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e25846","DOI":"10.1097\/MD.0000000000025846","article-title":"Composite hemangioendothelioma of the spleen with multiple metastases: CT findings and review of the literature","volume":"100","author":"Li","year":"2021","journal-title":"Med (Baltimore)"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.23017","article-title":"Recurrent PTBP1::MAML2 fusions in composite hemangioendothelioma with neuroendocrine differentiation: A report of two cases involving neck lymph nodes","volume":"61","author":"Dermawan","year":"2022","journal-title":"Genes Chromosomes Cancer"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2012.04.021","article-title":"Composite hemangioendothelioma on the neck","volume":"28","author":"Chen","year":"2012","journal-title":"Kaohsiung J Med Sci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2015.07.005","article-title":"Multifocal hemangioendothelioma of the lumbar spine and response to surgical resection and radiation","volume":"15","author":"Kelahan","year":"2015","journal-title":"Spine J"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3182873092","article-title":"Bone scan, MRI, and FDG PET\/CT findings in composite hemangioendothelioma of the manubrium sterni","volume":"39","author":"Dong","year":"2014","journal-title":"Clin Nucl Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318038f6b5","article-title":"Composite hemangioendothelioma: report of 5 cases including one with associated Maffucci syndrome","volume":"31","author":"Fukunaga","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13299","article-title":"Cutaneous epithelioid hemangioendothelioma treated with Mohs micrographic surgery","volume":"56","author":"Park","year":"2017","journal-title":"Int J Dermatol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1656872\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T04:11:54Z","timestamp":1756440714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1656872\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":22,"alternative-id":["10.3389\/fonc.2025.1656872"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1656872","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]},"article-number":"1656872"}}