{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:30:39Z","timestamp":1765344639523,"version":"3.46.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dedifferentiated liposarcoma (DDLPS) is a relatively common type of liposarcoma, typically occurring in the retroperitoneum and limbs. It is rarely found in the female reproductive system, leading to the absence of a standard treatment protocol for primary ovarian dedifferentiated liposarcoma. This case presents a personal experience-based approach, as there is a lack of standard treatment guidelines, relying on treatment consensus for more common locations and decades of clinical experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>This case report describes a 55-year-old woman who was admitted due to a gradually enlarging mass in the right lower abdomen, accompanied by bloating and abdominal pain. Physical examination revealed a palpable abdominal mass. Gynecological ultrasound showed a hyperechoic mass measuring 135*128*91mm in the pelvic-abdominal cavity. CT imaging suggested a large cystic and solid mixed liposarcoma originating from the ovary, with unclear delineation of the uterine fundus and slight compression of surrounding organs. Pelvic MRI revealed an irregular mass approximately 10.7cm\u00d712.6cm\u00d712.2cm, with slightly prolonged T1 and heterogeneous T2 signals, showing fat signal in the right fatty tissue, suggesting invasion of the uterine wall by liposarcoma. The patient then underwent open surgery, and postoperative pathology with immunohistochemistry confirmed dedifferentiated liposarcoma. FISH testing was positive for MDM2, confirming the diagnosis of ovarian-origin dedifferentiated liposarcoma. Although the patient refused chemotherapy, she has been followed up every three months, and the current follow-up shows no signs of tumor recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ovarian dedifferentiated liposarcoma is an extremely rare condition, with surgery being the preferred treatment method. This report presents a rare case of ovarian dedifferentiated liposarcoma, providing a reference for clinical diagnosis and treatment. Through collaboration between gynecology, pathology, and imaging departments, the accuracy of the diagnosis and comprehensiveness of treatment were ensured. Long-term follow-up of the patient provided valuable insights into the recurrence and prognosis of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1665723","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:26:28Z","timestamp":1765344388000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary dedifferentiated liposarcoma of the ovary: expanding the surgical management spectrum with a different resection extent than existing reports \u2013 a case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Hao","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxia","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuzhi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zili","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangtao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2024.102846","article-title":"Diagnosis and management of dedifferentiated liposarcoma: A multidisciplinary position statement","volume":"131","author":"Haddox","year":"2024","journal-title":"Cancer Treat Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e30691","DOI":"10.1097\/MD.0000000000030691","article-title":"Dedifferentiated liposarcoma found in ovary: A rare case report","volume":"101","author":"Chen","year":"2022","journal-title":"Med (Baltimore)"},{"key":"B3","article-title":"Dedifferentiated liposarcoma","volume-title":"WHO Classification of Tumours Editorial Board. Soft tissue and bone tumours","author":"Dei Tos","year":"2020"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199412000-00004","article-title":"Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas","volume":"18","author":"McCormick","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"7941","DOI":"10.1038\/s41467-024-52067-1","article-title":"Cellular origin and clonal evolution of human dedifferentiated liposarcoma","volume":"15","author":"Gruel","year":"2024","journal-title":"Nat Commun"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-305","article-title":"Intraperitoneal dedifferentiated liposarcoma showing MDM2 amplification: case report","volume":"11","author":"Grifasi","year":"2013","journal-title":"World J Surg Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2019.02.006","article-title":"Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review","volume":"36","author":"Thway","year":"2019","journal-title":"Semin Diagn Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-018-2777-3","article-title":"Primary anatomical site, adjuvant therapy, and other prognostic variables for dedifferentiated liposarcoma","volume":"145","author":"Gootee","year":"2019","journal-title":"J Cancer Res Clin Oncol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.10.009","article-title":"Predictors of outcomes in patients with primary retroperitoneal dedifferentiated liposarcoma undergoing surgery","volume":"218","author":"Keung","year":"2014","journal-title":"J Am Coll Surgeons"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1159\/000064038","article-title":"Characterization of supernumerary rings and giant marker chromosomes in well-differentiated lipomatous tumors by a combination of G-banding, CGH, M-FISH, and chromosome- and locus-specific FISH","volume":"97","author":"Micci","year":"2002","journal-title":"Cytogenetic Genome Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1097\/PAP.0000000000000101","article-title":"Dedifferentiated liposarcoma: updates on morphology, genetics, and therapeutic strategies","volume":"23","author":"Thway","year":"2016","journal-title":"Adv anatomic Pathol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1941710","article-title":"The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor","volume":"24","author":"Manfredi","year":"2010","journal-title":"Genes Dev"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-0203","article-title":"MDM2 derived from dedifferentiated liposarcoma extracellular vesicles induces MMP2 production from preadipocytes","volume":"79","author":"Casadei","year":"2019","journal-title":"\u201d Cancer Res"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021342","article-title":"FISH diagnostic assessment of MDM2 amplification in liposarcoma: potential pitfalls and troubleshooting recommendations","volume":"24","author":"Gambella","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000910","article-title":"Dedifferentiated liposarcoma with epithelioid\/epithelial features","volume":"41","author":"Makise","year":"2017","journal-title":"\u201d Am J Surg Pathol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.9598","article-title":"Clinical and molecular spectrum of liposarcoma","volume":"36","author":"Lee","year":"2018","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.xgen.2023.100321","article-title":"Impact of supraphysiologic MDM2 expression on chromatin networks and therapeutic responses in sarcoma","volume":"3","author":"Bevill","year":"2023","journal-title":"Cell Genomics"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.11004","article-title":"Phase 2 study of the CDK4 nhibitor abemaciclib in dedifferentiated liposarcoma","volume":"37","author":"Dickson","year":"2019","journal-title":"J Clin Oncol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-0153","article-title":"The MDM2-p53 antagonist brigimadlin (BI 907828) n patients with advanced or metastatic solid tumors: results of a phase ia, first-in-human, dose-escalation study","volume":"13","author":"LoRusso","year":"2023","journal-title":"Cancer Discov"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11864-018-0520-6","article-title":"Surgery for abdominal well-differentiated liposarcoma","volume":"19","author":"Mansfield","year":"2018","journal-title":"Curr Treat options Oncol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12625","article-title":"Second primary Malignancies in patients with well-differentiated\/dedifferentiated liposarcoma","volume":"38","author":"Jung","year":"2018","journal-title":"Anticancer Res"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000145","article-title":"Primary endometrioid stromal sarcoma of the ovary: a clinicopathologic study of 27 cases with morphologic and behavioral features similar to those of uterine low-grade endometrial stromal sarcoma","volume":"38","author":"Oliva","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/PGP.0000000000000145","article-title":"Primary myxoid liposarcoma of the ovary in a postpartum female: a case report and review of literature","volume":"34","author":"Liang","year":"2015","journal-title":"Int J Gynecol Pathol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14395","article-title":"Primary low grade myxoid liposarcoma of the ovary: A case report and review of literature","volume":"46","author":"\u00d6z Atalay","year":"2020","journal-title":"J Obstet Gynaecol Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-09654-z","article-title":"Management of primary retroperitoneal sarcoma (RPS) in the adult: an updated consensus approach from the transatlantic australasian RPS working group","volume":"28","author":"Swallow","year":"2021","journal-title":"\u201d Ann Surg Oncol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1057-5[26","article-title":"Aggressive surgery in retroperitoneal soft tissue sarcoma carried out at high-volume centers is safe and is associated with improved local control","volume":"17","author":"Bonvalot","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa012337","article-title":"Hospital volume and surgical mortality in the United States","volume":"346","author":"Birkmeyer","year":"2002","journal-title":"New Engl J Med"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07421-9","article-title":"Survival benefit of the surgical management of retroperitoneal sarcoma in a reference center: A nationwide study of the french sarcoma group from the netSarc database","volume":"26","author":"Bonvalot","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jamcollsurg.2019.09.013","article-title":"Identifying the minimum volume threshold for retroperitoneal soft tissue sarcoma resection: merging national data with consensus expert opinion","volume":"230","author":"Villano","year":"2020","journal-title":"\u201d J Am Coll Surgeons"},{"key":"B30","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1093\/annonc\/mdy471","article-title":"Medical oncologists must get more involved in systemic treatment of hepatocellular carcinoma","volume":"30","author":"Raoul","year":"2019","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.humpath.2017.02.015","article-title":"Correlation of histological grade of dedifferentiation with clinical outcome in 55 patients with dedifferentiated liposarcomas","volume":"66","author":"Dantey","year":"2017","journal-title":"Hum Pathol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001554","article-title":"A proposed staging system for improved prognostication of MDM2-amplified liposarcoma","volume":"45","author":"Tucci","year":"2021","journal-title":"Am J Surg Pathol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2024.103487","article-title":"Current unmet needs in locally advanced (unresectable) or metastatic dedifferentiated liposarcoma, the relevance of progression-free survival as clinical endpoint, and expectations for future clinical trial design: an international Delphi consensus report","volume":"9","author":"Sch\u00f6ffski","year":"2024","journal-title":"ESMO Open"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388","article-title":"The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA: Cancer J Clin"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.7042","article-title":"The AJCC 8th edition staging system for soft tissue sarcoma of the extremities or trunk: A cohort study of the SEER database","volume":"16","author":"Cates","year":"2018","journal-title":"J Natl Compr Cancer Network: JNCCN"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1665723\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:26:29Z","timestamp":1765344389000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1665723\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":35,"alternative-id":["10.3389\/fonc.2025.1665723"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1665723","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"article-number":"1665723"}}