{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:59:13Z","timestamp":1784807953966,"version":"3.55.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore the differences in apparent diffusion coefficient (ADC) values based on the primary tumor and sentinel lymph node (SLN) for predicting N stages of gastric cancer (GC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and sixty histopathologically confirmed GC patients between April 2021 and October 2024 were prospectively recruited. Preoperative DW-MRI was performed, and ADC values from primary tumors (ADC\n                      <jats:sub>T<\/jats:sub>\n                      ) and SLNs (ADC\n                      <jats:sub>LN<\/jats:sub>\n                      ), along with their relative ratios (rADC\n                      <jats:sub>T<\/jats:sub>\n                      , rADC\n                      <jats:sub>LN<\/jats:sub>\n                      ), were measured. Differences in these parameters across N stages were analyzed using the Kruskal-Wallis test. Receiver operating characteristic analysis was used to evaluate their diagnostic performances for predicting N0 vs. N1\u20133 stages, N0 + 1 vs. N2 + 3 stages, and N0 + 1 + 2 vs. N3 stages.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant differences were observed in ADC\n                      <jats:sub>T<\/jats:sub>\n                      , rADC\n                      <jats:sub>T<\/jats:sub>\n                      , ADC\n                      <jats:sub>LN<\/jats:sub>\n                      , and rADC\n                      <jats:sub>LN<\/jats:sub>\n                      values across N stages (all\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001). The AUC values of ADC\n                      <jats:sub>T<\/jats:sub>\n                      , rADC\n                      <jats:sub>T<\/jats:sub>\n                      , ADC\n                      <jats:sub>LN<\/jats:sub>\n                      , and rADC\n                      <jats:sub>LN<\/jats:sub>\n                      for predicting N0 vs. N1 + 2 + 3 stages were 0.753, 0.727, 0.782, 0.792, respectively. The AUC values of ADC\n                      <jats:sub>T<\/jats:sub>\n                      , rADC\n                      <jats:sub>T<\/jats:sub>\n                      , ADC\n                      <jats:sub>LN<\/jats:sub>\n                      , and rADC\n                      <jats:sub>LN<\/jats:sub>\n                      for predicting N0 + 1 vs. N2 + 3 stages were 0.776, 0.767, 0.844, 0.837, respectively. The AUC values of ADC\n                      <jats:sub>T<\/jats:sub>\n                      , rADC\n                      <jats:sub>T<\/jats:sub>\n                      , ADC\n                      <jats:sub>LN<\/jats:sub>\n                      , and rADC\n                      <jats:sub>LN<\/jats:sub>\n                      for predicting N0 + 1 + 2 vs. N3 stages were 0.797, 0.792, 0.857, 0.848, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both primary tumor- and SLN-derived ADC values can effectively differentiate N stages among patients with GC. SLN-based ADC parameters exhibit superior diagnostic performance compared to primary tumor-based measurements in stratifying N-stage progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1667430","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:14:48Z","timestamp":1764306888000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of apparent diffusion coefficient values in sentinel lymph nodes versus primary tumors for gastric cancer N 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