{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:34:19Z","timestamp":1791297259263,"version":"4.1.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Our patient exhibited situs inversus totalis (SIT)\u2014a developmental quirk resulting in right\u2013left transposition of all visceral organs, including the heart, liver, and spleen. While prior case reports have described colorectal carcinoma in individuals with SIT, to our knowledge, this case represents an exceptionally rare presentation of primary cecal carcinoma within this anatomical context. This case describes a patient undergoing laparoscopic right hemicolectomy for adenocarcinoma of the cecum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A patient presented to our institution in May 2024. Subsequent diagnostic workup confirmed a diagnosis of cecal carcinoma. Given the absolute contraindication for bowel preparation secondary to complete bowel obstruction, along with radiologically confirmed cecal malignancy and elevated serum tumor markers, a multidisciplinary consensus was reached to proceed with laparoscopic right hemicolectomy after obtaining proper informed consent from the patient\u2019s family. Pathology confirmed a T3N0M0 well-differentiated adenocarcinoma. Twelve-month consecutive postoperative follow-up data confirmed the absence of surgical complications such as anastomotic leakage or infection, as well as no clinical or radiographic evidence of disease recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although the reversed anatomy in SIT patients presents inherent technical challenges for laparoscopic surgery, this minimally invasive approach can still achieve comparable safety and efficacy to conventional procedures when performed by experienced surgeons with adequate anatomical understanding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1668016","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T05:16:42Z","timestamp":1763011002000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Laparoscopic right hemicolectomy in situs inversus totalis with cecal carcinoma: a case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Bowen","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongpeng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-0909-4","article-title":"Hepatic resection for metastatic colon cancer in patients with situs inversus totalis complicated by multiple anomalies of the hepatobiliary system: the first case report","volume":"13","author":"Uemura","year":"2009","journal-title":"J Gastrointest Surg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-014-1075-9","article-title":"Single-incision laparoscopic surgery for colon cancer in patient with situs inversus totalis: report of a case","volume":"77","author":"Hirano","year":"2015","journal-title":"Indian J Surg"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHSURG.1949.01240030734014","article-title":"Situs inversus totalis; a statistical review of data on 76 cases with special reference to disease of the biliary tract","volume":"58","author":"Mayo","year":"1949","journal-title":"Arch Surg (Chic Ill,: 1920)"},{"key":"B4","article-title":"Situs inversus: Review of the literature, report of four cases and analysis of the clinical implications","volume":"33","author":"Varano","year":"1960","journal-title":"J Int Coll Surg"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.813253","article-title":"Comprehensive molecular profiling of colorectal cancer with situs inversus totalis by next-generation sequencing","volume":"12","author":"Li","year":"2022","journal-title":"Front Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-9-109","article-title":"Double primary Malignancies associated with colon cancer in patients with situs inversus totalis: two case reports","volume":"9","author":"Kim","year":"2011","journal-title":"World J Surg Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00019","article-title":"Estrogen receptors and their implications in colorectal carcinogenesis","volume":"5","author":"Francesco","year":"2015","journal-title":"Front Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152337699","article-title":"Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia","volume":"99","author":"Bartoloni","year":"2002","journal-title":"PNAS"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2011-100457","article-title":"A human laterality disorder associated with recessive CCDC11 mutation","volume":"49","author":"Perles","year":"2012","journal-title":"J Med Genet"},{"key":"B10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12893-018-0394-3","article-title":"Robotic low anterior resection plus transanal natural orifice specimen extraction in a patient with situs inversus totalis","volume":"18","author":"Cui","year":"2018","journal-title":"BMC Surg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1891\/0730-0832.20.1.63","article-title":"Situs inversus totalis","volume":"20","author":"Spoon","year":"2001","journal-title":"Neonatal netw : NN"},{"key":"B12","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/scientificamerican0699-46","article-title":"How the body tells left from right","volume":"280","author":"Izpis\u00faa Belmonte","year":"1999","journal-title":"Sci Am"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2020.09.003","article-title":"Transverse colon cancer with obstruction in a patient with situs inversus totalis: a case report and review of literature","volume":"43","author":"Xu","year":"2020","journal-title":"Asian J Surg"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1249","article-title":"The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium","volume":"7","author":"Teng","year":"2005","journal-title":"Nat Cell Biol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i37.5035","article-title":"Laparoscopic hemicolectomy in a patient with situs inversus totalis","volume":"13","author":"Fujiwara","year":"2007","journal-title":"World J Gastroenterol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.5.790","article-title":"Laparoscopic total mesorectal excision in a rectal cancer patient with situs inversus totalis","volume":"25","author":"Huh","year":"2010","journal-title":"J Korean Med Sci"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-010-4530-7","article-title":"Laparoscopic right hemicolectomy with D3 lymph node dissection for a patient with situs inversus totalis: report of a case","volume":"41","author":"Kim","year":"2011","journal-title":"Surg Today"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v5.i2.22","article-title":"Laparoscopic hemicolectomy in a patient with situs inversus totalis after open distal gastrectomy","volume":"5","author":"Sumi","year":"2013","journal-title":"World J Gastrointest Surg"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-67202014000400018","article-title":"Colorectal cancer and situs inversus totalis: Case report","volume":"27","author":"Basso","year":"2014","journal-title":"Arq Bras cir dig"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.9738\/INTSURG-D-14-00217.1","article-title":"Laparoscopic sigmoidectomy for a patient with situs inversus totalis: effect of changing operator position","volume":"100","author":"Yaegashi","year":"2015","journal-title":"Int Surg"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2017.10.011","article-title":"Laparoscopic hemicolectomy for a patient with situs inversus totalis: a case report","volume":"41","author":"Sasaki","year":"2017","journal-title":"Int J Surg Case Rep"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/ases.12483","article-title":"Laparoscopic sigmoidectomy in a case of sigmoid colon cancer with situs inversus totalis","volume":"12","author":"Takeda","year":"2019","journal-title":"Asian J Endosc Surg"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjz080","article-title":"Laparoscopic right colectomy for a patient with situs inversus totalis","volume":"2019","author":"Kojima","year":"2019","journal-title":"J Surg Case Rep"},{"key":"B24","doi-asserted-by":"publisher","first-page":"68","DOI":"10.4103\/jmas.JMAS_13_18","article-title":"Laparoscopic colon resection in patients with situs inversus totalis: is it the same operation as in patients without situs inversus totalis","volume":"15","author":"Karabay","year":"2019","journal-title":"J Minimal Access Surg"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v12.i9.3101","article-title":"Laparoscopy-assisted resection of colorectal cancer with situs inversus totalis: a case report and literature review","volume":"12","author":"Chen","year":"2020","journal-title":"World J Gastrointest Endosc"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/ases.12937","article-title":"Robotic-assisted surgery for rectal cancer with situs inversus totalis: a case report","volume":"14","author":"Kasai","year":"2021","journal-title":"Asian J Endosc Surg"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/ases.12944","article-title":"Laparoscopic sigmoidectomy with splenic flexure mobilization for colon cancer in situs inversus totalis: preoperative assessment and preparation","volume":"15","author":"Kudo","year":"2022","journal-title":"Asian J Endosc Surg"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjab568","article-title":"Descending colon cancer in a patient with situs inversus totalis: a case report and literature review","volume":"2022","author":"Cheng","year":"2022","journal-title":"J Surg Case Rep"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i16.5435","article-title":"Laparoscopic radical resection for situs inversus totalis with colonic splenic flexure carcinoma: a case report","volume":"10","author":"Zheng","year":"2022","journal-title":"World J Clin Cases"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v13.i10.848","article-title":"Ascending colon cancer and situs inversus totalis - altered surgeon position for successful laparoscopic hemicolectomy: a case report","volume":"13","author":"Hu","year":"2022","journal-title":"World J Clin Oncol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1186\/s13256-024-04903-7","article-title":"Rectal cancer with situs inversus totalis and previous Malignant middle cerebral artery infarction: a case report and review of the literature","volume":"18","author":"Song","year":"2024","journal-title":"J Med Case Rep"},{"key":"B32","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s40792-024-01982-y","article-title":"Robotic hemi-colectomy for ascending colon cancer in a patient with situs inversus totalis","volume":"10","author":"Kato","year":"2024","journal-title":"Surg Case Rep"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.70352\/scrj.cr.25-0073","article-title":"Robot-assisted gastrectomy and sigmoid colectomy with situs inversus totalis: a case report","volume":"11","author":"Hara","year":"2025","journal-title":"Surg Case Rep"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.70352\/scrj.cr.24-0016","article-title":"Two cases of single-incision laparoscopic surgery for sigmoid colon and rectal cancer in situs inversus totalis","volume":"11","author":"Miyasaka","year":"2025","journal-title":"Surg Case Rep"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-003-9051-7","article-title":"Laparoscopic cholecystectomy in situs inversus totalis: the importance of being left-handed","volume":"17","author":"Oms","year":"2003","journal-title":"Surg Endosc"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1668016\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T05:16:43Z","timestamp":1763011003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1668016\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"references-count":35,"alternative-id":["10.3389\/fonc.2025.1668016"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1668016","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]},"article-number":"1668016"}}