{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:27:36Z","timestamp":1759364856507,"version":"build-2065373602"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Gastrointestinal stromal tumors (GISTs), mesenchymal neoplasms of the gastrointestinal tract, are prone to recurrence and metastasis. Despite improvements in prognosis with targeted treatments, such as imatinib, some patients develop metastatic GIST. Renal involvement in GIST is uncommon, and data on the diagnosis and treatment of GIST with renal metastasis remain limited. In this report, we describe the diagnostic and therapeutic regimen used for a patient with renal metastasis from GIST, providing an important reference for clinicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 52-year-old man underwent resection of a gastric GIST 5 years previously and had received adjuvant imatinib therapy for 2 years. A radical nephrectomy was performed, and histopathological analysis confirmed metastatic GIST. Although the patient resumed imatinib therapy post-surgery, follow-up imaging 22 months later revealed multiple metastases in the retroperitoneum and abdominal cavity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Renal metastasis from GIST is highly aggressive. Although surgical resection offers considerable palliation and may prolong survival, survival is generally dependent on sustained multimodal therapy and follow-up. Early detection and management of recurrent or metastatic lesions are imperative to optimize long-term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1669412","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T04:16:43Z","timestamp":1759292203000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Renal metastasis of a gastric gastrointestinal stromal tumor mimicking a primary renal carcinoma"],"prefix":"10.3389","volume":"15","author":[{"given":"Xiaoxiao","family":"Bao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bifei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i26.2806","article-title":"Current clinical management of gastrointestinal stromal tumor","volume":"24","author":"Akahoshi","year":"2018","journal-title":"World J Gastroenterol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2016.12.001","article-title":"Management of gastrointestinal stromal tumors","volume":"97","author":"Keung","year":"2017","journal-title":"Surg Clin North Am"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000158","article-title":"What is new in gastrointestinal stromal tumor","volume":"24","author":"Schaefer","year":"2017","journal-title":"Adv Anat Pathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyad167","article-title":"Molecular advances in the treatment of advanced gastrointestinal stromal tumor","volume":"28","author":"Venkataraman","year":"2023","journal-title":"Oncologist"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/his.12524","article-title":"Metastases to the kidney: a clinicopathological study of 43 cases with an emphasis on deceptive features","volume":"66","author":"Wu","year":"2015","journal-title":"Histopathology"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.06.003","article-title":"Surgical management of metastatic gastrointestinal stromal tumour","volume":"44","author":"Schrage","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000338","article-title":"Secondary tumors of the kidney: a comprehensive clinicopathologic analysis","volume":"29","author":"Saeed","year":"2022","journal-title":"Adv Anat Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-021-00837-0","article-title":"Surgical management of metastatic gastrointestinal stromal tumors","volume":"22","author":"Yonkus","year":"2021","journal-title":"Curr Treat Options Oncol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10774","article-title":"Prediction of morbidity following cytoreductive surgery for metastatic gastrointestinal stromal tumour in patients on tyrosine kinase inhibitor therapy","volume":"105","author":"Fairweather","year":"2018","journal-title":"Br J Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40487-015-0014-7","article-title":"Contemporary management of metastatic gastrointestinal stromal tumors: systemic and locoregional approaches","volume":"4","author":"Ang","year":"2016","journal-title":"Oncol Ther"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020493","article-title":"Gastrointestinal stromal tumors (GISTs): novel therapeutic strategies with immunotherapy and small molecules","volume":"22","author":"Vallilas","year":"2021","journal-title":"Int J Mol Sci"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1669412\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T04:16:46Z","timestamp":1759292206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1669412\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":11,"alternative-id":["10.3389\/fonc.2025.1669412"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1669412","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"article-number":"1669412"}}