{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:16:04Z","timestamp":1791098164678,"version":"4.1.0"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Acute lymphoblastic leukemia poses substantial challenges in therapeutic management. As a novel form of programmed cell death, ferroptosis has emerged as a promising research direction in cancer therapy. Studies have emphasized the pivotal role of ferroptosis in ALL, indicating that targeting this pathway could provide a novel therapeutic strategy. This article systematically reviews the molecular regulatory mechanisms of ferroptosis in ALL and explores its potential clinical applications in the treatment and prognostic evaluation of the disease.<\/jats:p>","DOI":"10.3389\/fonc.2025.1669432","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T05:14:38Z","timestamp":1767935678000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Ferroptosis: a new dawn in the treatment of acute lymphoblastic leukemia"],"prefix":"10.3389","volume":"15","author":[{"given":"Jiongping","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiying","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00428-022-03448-8","article-title":"International Consensus Classification of acute lymphoblastic leukemia\/lymphoma","volume":"482","author":"Duffield","year":"2023","journal-title":"Virchows Arch"},{"key":"B2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J Clin"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1200\/jco.22.01297","article-title":"Outcomes of childhood noninfant acute lymphoblastic leukemia with 11q23\/KMT2A rearrangements in a modern therapy era: A retrospective international study","volume":"41","author":"Attarbaschi","year":"2023","journal-title":"J Clin Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2411680","article-title":"Blinatumomab in standard-risk B-cell acute lymphoblastic leukemia in children","volume":"392","author":"Gupta","year":"2025","journal-title":"N Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41408-020-00342-x","article-title":"Blinatumomab in pediatric patients with relapsed\/refractory acute lymphoblastic leukemia: results of the RIALTO trial, an expanded access study","volume":"10","author":"Locatelli","year":"2020","journal-title":"Blood Cancer J"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","article-title":"Ferroptosis: mechanisms and links with diseases","volume":"6","author":"Yan","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.cell.2020.04.039","article-title":"SnapShot: ferroptosis","volume":"181","author":"Hadian","year":"2020","journal-title":"Cell"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.03.036","article-title":"Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1","volume":"11","author":"Kong","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4193","DOI":"10.1038\/s41467-023-39901-8","article-title":"ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis","volume":"14","author":"Yang","year":"2023","journal-title":"Nat Commun"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306298","article-title":"BHLHE40 inhibits ferroptosis in pancreatic cancer cells via upregulating SREBF1","volume":"11","author":"Cao","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1016\/j.cmet.2023.09.004","article-title":"Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1","volume":"35","author":"Zhao","year":"2023","journal-title":"Cell Metab"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.04.001","article-title":"Role of iron in cancer","volume":"76","author":"Salnikow","year":"2021","journal-title":"Semin Cancer Biol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2174\/0115665232279426240217174738","article-title":"Effect of bovine lactoferrin treatment on iron homeostasis and gene expression changes in multiple organ dysfunctions during wound healing process in rats","volume":"24","author":"Bozkurt","year":"2024","journal-title":"Curr Gene Ther"},{"key":"B19","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.tips.2020.11.003","article-title":"Ferrous iron-dependent pharmacology","volume":"42","author":"Gonciarz","year":"2021","journal-title":"Trends Pharmacol Sci"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07623-6","article-title":"Emergence of large-scale cell death through ferroptotic trigger waves","volume":"631","author":"Co","year":"2024","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3390\/biology10030184","article-title":"Lipid metabolism and ferroptosis","volume":"10","author":"Lee","year":"2021","journal-title":"Biol (Basel)"},{"key":"B22","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.cell.2024.10.047","article-title":"ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization","volume":"188","author":"Wang","year":"2025","journal-title":"Cell"},{"key":"B23","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"804","DOI":"10.3390\/cells12050804","article-title":"Polyunsaturated fatty acids drive lipid peroxidation during ferroptosis","volume":"12","author":"Mortensen","year":"2023","journal-title":"Cells"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpan.2025.03.003","article-title":"Chaigui Bitong decoction inhibits rheumatoid arthritis fibroblast-like synoviocyte injury through regulating the ferroptosis signaling pathway via Nrf2\/HO-1\/GPX4 axis","volume":"21","author":"Tang","year":"2025","journal-title":"Curr Pharm Analysis"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2017-0540","article-title":"Overexpression of SLC7A11: a novel oncogene and an indicator of unfavorable prognosis for liver carcinoma","volume":"14","author":"Zhang","year":"2018","journal-title":"Future Oncol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2194-1","article-title":"Mechanisms of ferroptosis","volume":"73","author":"Cao","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1039\/d3cs00001j","article-title":"Stimuli-responsive ferroptosis for cancer therapy","volume":"52","author":"Kang","year":"2023","journal-title":"Chem Soc Rev"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"E9","DOI":"10.1038\/s41586-023-06269-0","article-title":"DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition","volume":"619","author":"Mishima","year":"2023","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent Sci"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.05.019","article-title":"The Nrf2\/GCH1\/BH4 axis ameliorates radiation-induced skin injury by modulating the ROS cascade","volume":"137","author":"Xue","year":"2017","journal-title":"J Invest Dermatol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.7150\/jca.57054","article-title":"Artemisinin derivatives inhibit non-small cell lung cancer cells through induction of ROS-dependent apoptosis\/ferroptosis","volume":"12","author":"Zhang","year":"2021","journal-title":"J Cancer"},{"key":"B37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3892\/ol.2020.11918","article-title":"Erastin triggers autophagic death of breast cancer cells by increasing intracellular iron levels","volume":"20","author":"Li","year":"2020","journal-title":"Oncol Lett"},{"key":"B38","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12943-024-02217-2","article-title":"Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance","volume":"24","author":"Zhao","year":"2025","journal-title":"Mol Cancer"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103158","article-title":"PM(2.5)-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner","volume":"72","author":"Li","year":"2024","journal-title":"Redox Biol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2170960","article-title":"ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4","volume":"19","author":"Wu","year":"2023","journal-title":"Autophagy"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c07255","article-title":"Ferritinophagy mediated by oxidative stress-driven mitochondrial damage is involved in the polystyrene nanoparticles-induced ferroptosis of lung injury","volume":"17","author":"Yang","year":"2023","journal-title":"ACS Nano"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.03.011","article-title":"The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions","volume":"42","author":"Lei","year":"2024","journal-title":"Cancer Cell"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1177\/1533033818764470","article-title":"High-dose deferoxamine treatment disrupts intracellular iron homeostasis, reduces growth, and induces apoptosis in metastatic and nonmetastatic breast cancer cell lines","volume":"17","author":"Bajbouj","year":"2018","journal-title":"Technol Cancer Res Treat"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11830","article-title":"The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2\/\u03b2-catenin signaling in human multiple myeloma","volume":"7","author":"Kamihara","year":"2016","journal-title":"Oncotarget"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1239257","article-title":"Iron chelation: an adjuvant therapy to target metabolism, growth and survival of murine PTEN-deficient T lymphoma and human T lymphoblastic leukemia\/lymphoma","volume":"58","author":"Benadiba","year":"2017","journal-title":"Leuk Lymphoma"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-24-1941","article-title":"Ferroptotic neutrophils induce immunosuppression and chemoresistance in breast cancer","volume":"85","author":"Zeng","year":"2025","journal-title":"Cancer Res"},{"key":"B47","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41419-025-07704-y","article-title":"Deep transfer learning approach for automated cell death classification reveals novel ferroptosis-inducing agents in subsets of B-ALL","volume":"16","author":"Stachura","year":"2025","journal-title":"Cell Death Dis"},{"key":"B48","doi-asserted-by":"publisher","first-page":"737","DOI":"10.3390\/genes16070737","article-title":"MYB confers sorafenib resistance in human leukemia cells via inhibiting ferroptosis through FTH1 upregulation","volume":"16","author":"Tao","year":"2025","journal-title":"Genes (Basel)"},{"key":"B49","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bcp.2017.06.112","article-title":"Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death","volume":"140","author":"Probst","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2023.101850","article-title":"Tetraarsenic tetrasulfide triggers ROS-induced apoptosis and ferroptosis in B-cell acute lymphoblastic leukaemia by targeting HK2","volume":"40","author":"Bai","year":"2024","journal-title":"Transl Oncol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204281","article-title":"Realgar (As(4)S(4)), a traditional Chinese medicine, induces acute promyelocytic leukemia cell death via the Bcl-2\/Bax\/Cyt-C\/AIF signaling pathway in vitro","volume":"14","author":"Li","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-022-03507-5","article-title":"Long-term retrospective study of retinoic acid combined with arsenic and chemotherapy for acute promyelocytic leukemia","volume":"117","author":"Zhang","year":"2023","journal-title":"Int J Hematol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2022.0661","article-title":"Effect of the mitogen-activated protein kinase pathway on the erastin-induced ferroptosis of molt-4 cells","volume":"42","author":"Liu","year":"2023","journal-title":"DNA Cell Biol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3892\/ol.2024.14470","article-title":"Dihydroartemisinin induces ferroptosis in T cell acute lymphoblastic leukemia cells by downregulating SLC7A11 and activating the ATF4\u2212CHOP signaling pathway","volume":"28","author":"Tang","year":"2024","journal-title":"Oncol Lett"},{"key":"B55","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.celrep.2019.03.067","article-title":"Phenformin, but not metformin, delays development of T cell acute lymphoblastic leukemia\/lymphoma via cell-autonomous AMPK activation","volume":"27","author":"Vara-Ciruelos","year":"2019","journal-title":"Cell Rep"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.338","article-title":"AMPK inhibition enhances apoptosis in MLL-rearranged pediatric B-acute lymphoblastic leukemia cells","volume":"27","author":"Accordi","year":"2013","journal-title":"Leukemia"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.32604\/or.2024.049757","article-title":"Apigenin facilitates apoptosis of acute lymphoblastic leukemia cells via AMP-activated protein kinase-mediated ferroptosis","volume":"33","author":"He","year":"2025","journal-title":"Oncol Res"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.149125","article-title":"A GPX4 non-enzymatic domain and MDM2 targeting peptide PROTAC for acute lymphoid leukemia therapy through ferroptosis induction","volume":"684","author":"Niu","year":"2023","journal-title":"Biochem Biophys Res Commun"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e36608","article-title":"Evaluation of ferroptosis-based anti-leukemic activities of ZnO nanoparticles synthesized by a green route against Pre-B acute lymphoblastic leukemia cells (Nalm-6 and REH)","volume":"10","author":"Ashoub","year":"2024","journal-title":"Heliyon"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.740884","article-title":"Autophagy regulates VDAC3 ubiquitination by FBXW7 to promote erastin-induced ferroptosis in acute lymphoblastic leukemia","volume":"9","author":"Zhu","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1177\/15353702211004870","article-title":"Inhibitory effect of hydnocarpin D on T-cell acute lymphoblastic leukemia via induction of autophagy-dependent ferroptosis","volume":"246","author":"Lou","year":"2021","journal-title":"Exp Biol Med (Maywood)"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.08.065","article-title":"Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt\/\u03b2-catenin signaling pathway in colon cancer cells","volume":"23","author":"Lee","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.03.105","article-title":"(PAA) inhibits T-cell acute lymphoblastic leukemia through inducing autophagic cell death and ferroptosis","volume":"608","author":"Chen","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.673506","article-title":"The complexity of the tumor microenvironment and its role in acute lymphoblastic leukemia: implications for therapies","volume":"11","author":"Simioni","year":"2021","journal-title":"Front Oncol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-025-02734-z","article-title":"Distinct stromal cell populations define the B-cell acute lymphoblastic leukemia microenvironment","volume":"39","author":"Ferrao Blanco","year":"2025","journal-title":"Leukemia"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-376061","article-title":"Notch signaling in acute lymphoblastic leukemia: any role for stromal microenvironment","volume":"118","author":"Nwabo Kamdje","year":"2011","journal-title":"Blood"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-184069","article-title":"NOTCH1\/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study","volume":"113","author":"Asnafi","year":"2009","journal-title":"Blood"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1097\/mph.0000000000001006","article-title":"Study of NOTCH1 and FBXW7 mutations and its prognostic significance in south Indian T-cell acute lymphoblastic leukemia","volume":"40","author":"Valliyammai","year":"2018","journal-title":"J Pediatr Hematol Oncol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13045-017-0431-1","article-title":"Spectrum of somatic mutations detected by targeted next-generation sequencing and their prognostic significance in adult patients with acute lymphoblastic leukemia","volume":"10","author":"Feng","year":"2017","journal-title":"J Hematol Oncol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.48.5292","article-title":"Toward a NOTCH1\/FBXW7\/RAS\/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study","volume":"31","author":"Trinquand","year":"2013","journal-title":"J Clin Oncol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2553","article-title":"Activating Notch1 mutations in mouse models of T-ALL","volume":"107","author":"O'Neil","year":"2006","journal-title":"Blood"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-136762","article-title":"Targeting the Notch1 and mTOR pathways in a mouse T-ALL model","volume":"113","author":"Cullion","year":"2009","journal-title":"Blood"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-692582","article-title":"The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia","volume":"129","author":"Sanchez-Martin","year":"2017","journal-title":"Blood"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3955","article-title":"Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia","volume":"21","author":"Herranz","year":"2015","journal-title":"Nat Med"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144726","article-title":"Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway","volume":"751","author":"Liu","year":"2020","journal-title":"Gene"},{"key":"B77","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1080\/16078454.2021.2008590","article-title":"Circ_0000745 promotes acute lymphoblastic leukemia progression through mediating miR-494-3p\/NET1 axis","volume":"27","author":"Yang","year":"2022","journal-title":"Hematology"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.2147\/ijgm.S422523","article-title":"The emerging roles and mechanisms of PAQR3 in human cancer: pathophysiology and therapeutic implications","volume":"16","author":"Guo","year":"2023","journal-title":"Int J Gen Med"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.437","article-title":"PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability","volume":"9","author":"Jin","year":"2021","journal-title":"Immun Inflammation Dis"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102408","article-title":"Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing","volume":"55","author":"Pontel","year":"2022","journal-title":"Redox Biol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2023.147597","article-title":"Silencing LCN2 enhances RSL3-induced ferroptosis in T cell acute lymphoblastic leukemia","volume":"879","author":"Tian","year":"2023","journal-title":"Gene"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.280786","article-title":"Genome-wide CRISPR screens identify ferroptosis as a novel therapeutic vulnerability in acute lymphoblastic leukemia","volume":"108","author":"Lalonde","year":"2023","journal-title":"Haematologica"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1186\/s12885-021-09076-w","article-title":"Identification of immune subtypes of Ph-neg B-ALL with ferroptosis related genes and the potential implementation of Sorafenib","volume":"21","author":"Hong","year":"2021","journal-title":"BMC Cancer"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1669432\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T05:14:40Z","timestamp":1767935680000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1669432\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":83,"alternative-id":["10.3389\/fonc.2025.1669432"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1669432","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]},"article-number":"1669432"}}