{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:45:08Z","timestamp":1791996308918,"version":"4.4.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Mucinous adenocarcinoma of the renal pelvis (MAC-RP) is an exceedingly rare condition, accounting for less than 1% of malignancies originating from this epithelial site. We report a case of MAC-RP in a woman presenting with right flank pain from obstructing stones, recurrent urinary tract infections, and ureteral stents. Imaging showed a right kidney mass consistent with xanthogranulomatous pyelonephritis (XGP) with an abscess surgically removed. Pathology after radical nephrectomy unexpectedly revealed\n                    <jats:italic>in situ<\/jats:italic>\n                    MAC-RP with intestinal metaplasia at the margin. Surveillance testing showed positive levels of CEA, CA19-9, and novel ctDNA and cfDNA despite negative results from pan-endoscopy and imaging. A subsequent monitoring imaging identified a right flank mass that was resected, confirming recurrent MAC-RP. The patient completed 6 months of adjuvant mFOLFOX6, as recommended in the MAC-colon cancer guidelines. The patient completed the treatment without any evidence of measurable molecular or radiological disease. At 4 months after the last systemic therapy, the patient\u2019s biomarkers were rising, matching radiological local, ovarian, and pleural recurrences, which were histologically confirmed. Since there are no established guidelines for MAC-RP, our team is the first to apply cutting-edge cancer technologies to inform future clinical decisions and molecular tumor board discussions and to compare the genomic distance of MAC-RP with that of other bladder or colorectal origin sites.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2025.1678970","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T05:44:23Z","timestamp":1768196663000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Novel molecular characterization of rare primary mucinous adenocarcinoma of the renal pelvis"],"prefix":"10.3389","volume":"15","author":[{"given":"Megan K.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irasema 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