{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:30:42Z","timestamp":1789684242307,"version":"4.0.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to identify histological and clinical parameters associated with an R1 resection status and the recurrence rate in surgically treated basal cell carcinomas (BCC) and to evaluate the impact of an initial R1 resection status on the likelihood of tumor recurrence. Understanding these associations is essential for optimizing surgical treatment strategies and reducing the risk of BCC recurrences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single-center study analyzed primary head and neck BCC surgically treated between 2019 and 2024 to evaluate patient and tumor characteristics, including histological subtype, tumor location, resection status, and recurrence rate. R0 was defined as complete excision with a safety margin of at least 3\u00a0mm or histopathological confirmation of complete tumor removal with tumor-free resection margins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 241 cases of head and neck BCC, an initial R1 resection status was significantly associated with the sclerodermiform subtype and auricular localization. Tumor clearance was achieved within one or two surgical stages in approximately 80% of cases. Despite these risk factors, organ preservation was possible in over 93%, and local anesthesia proved sufficient in 90% of procedures. The recurrence rate remained low at 2.1%. Reconstructive techniques were frequently required, with local flaps and skin grafts being the most used methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the effectiveness of outpatient procedures under local anesthesia on the one hand and the tissue-sparing and organ-preserving approach on the other for head and neck BCC, achieving high R0 resection and organ preservation rates. Incomplete resection was linked to the sclerodermiform subtype and auricular location. Despite these risks, recurrence was rare. The frequent use of reconstructive techniques reflects the focus on aesthetic and functional outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1679804","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T05:15:12Z","timestamp":1763961312000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of histological and clinical parameters on resection status and recurrence probability in head and neck basal cell carcinomas"],"prefix":"10.3389","volume":"15","author":[{"given":"Felix","family":"Deffner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Givi","family":"Magradze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kia","family":"Melzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Charlotta","family":"Schlieper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Knopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Christoph","family":"Ketterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000296","article-title":"Consensus for nonmelanoma skin cancer treatment: basal cell carcinoma, including a cost analysis of treatment methods","volume":"41","author":"Kauvar","year":"2015","journal-title":"Dermatol Surg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000907","article-title":"Safety of local intracutaneous lidocaine anesthesia used by dermatologic surgeons for skin cancer excision and postcancer reconstruction: quantification of standard injection volumes and adverse event rates","volume":"42","author":"Alam","year":"2016","journal-title":"Dermatol Surg"},{"key":"B3","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.jaad.2018.01.009","article-title":"Assessing the outcomes, risks, and costs of local versus general anesthesia: A review with implications for cutaneous surgery","volume":"78","author":"Locke","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1007\/s00403-025-04084-3","article-title":"Exploring the role of surgical margins and reoperation in basal cell carcinoma recurrence: a study of 3036 cases","volume":"317","author":"Iurilli","year":"2025","journal-title":"Arch Dermatol Res"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2023.10.106","article-title":"Revisiting basal cell carcinoma clinical margins: Leveraging natural language processing and multivariate analysis with updated Royal College of Pathologists histological reporting standards","volume":"88","author":"Ali","year":"2024","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15441","article-title":"Basal cell skin cancers: Retrospective analysis of 67 cases","volume":"21","author":"Ozbey","year":"2022","journal-title":"J Cosmet Dermatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14757","article-title":"Dermatoscopically narrowed surgical margins for head and neck basal cell carcinoma: A retrospective case-control study","volume":"20","author":"Herzum","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"B8","volume-title":"S2k-leitlinie basalzellkarzinom der haut","year":"2024"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.02.037","article-title":"Correlation of basal cell carcinoma subtype with histologically confirmed subclinical extension during Mohs micrographic surgery: A prospective multicenter study","volume":"86","author":"Lim","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.jaad.2020.04.008","article-title":"Surgical margins required for basal cell carcinomas treated with Mohs micrographic surgery according to tumor features","volume":"83","author":"Cerci","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00535.x","article-title":"Positive margins in basal cell carcinoma: relationship to clinical features and recurrence risk. 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