{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:15:35Z","timestamp":1776813335286,"version":"3.51.2"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Doege\u2013Potter syndrome (DPS) is a rare paraneoplastic condition characterized by hypoglycemia resulting from the excessive secretion of insulin-like growth factor-2 (IGF-2) by a solitary fibrous tumor (SFT). This report presents an elderly patient with DPS complicated by severe cardiac conduction abnormalities, illustrating the clinical manifestation, therapeutic intervention, and multidisciplinary management strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 78-year-old woman was diagnosed with DPS, presenting with loss of consciousness with a blood glucose level of 1.41 mmol\/L, and hypoglycemia was resolved with intravenous glucose. The initial laboratory investigation revealed elevated insulin levels of 7.17 \u03bcIU\/mL, with suppressed C-peptide levels of 0.09 ng\/mL and insulin-like growth factor-1 (IGF-1) levels of 26.47 ng\/mL. Thoracic computed tomography (CT) identified a 13.6 cm \u00d7 8.6 cm mass in the right lower thoracic cavity. CT-guided transthoracic biopsy confirmed SFT with immunohistochemical positivity for CD34 and STAT6. Electrocardiogram (ECG) demonstrated frequent atrial premature complexes (29,292\/24 hours), short runs of atrial tachycardia (144\/24 hours), and paroxysmal ventricular premature complexes. Echocardiography revealed severe aortic valve insufficiency. Following multidisciplinary team (MDT) consultation, the surgically ineligible patient received tumor-directed radiotherapy (60 Gy in 30 fractions), glucocorticoid replacement (hydrocortisone 40 mg daily), and overnight carbohydrate supplementation to alleviate hypoglycemia. At 18-month follow-up, serial chest CT showed tumor size reduction. Holter monitoring revealed a substantial reduction in atrial premature complexes (1,955\/24 hours vs. baseline 29,292\/24 hours). The patient exhibited no recurrence of hypoglycemic episodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This report describes a case of DPS with refractory hypoglycemia complicated by severe cardiac structural and conduction abnormalities. Radiotherapy combined with endocrine intervention effectively controlled tumor-associated hypoglycemia in this surgically ineligible patient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1681861","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T05:14:56Z","timestamp":1763961296000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Radiation therapy alleviates Doege\u2013Potter syndrome accompanied with severe aortic valve insufficiency: a case report and literature 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