{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:25:54Z","timestamp":1791055554504,"version":"4.1.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tumor lysis syndrome (TLS), characterized by electrolyte imbalances and acute kidney injury, predominantly occurs following cytotoxic chemotherapy in hematologic malignancies. Spontaneous TLS (STLS) in solid tumors remains rare. This report describes STLS induced by a diagnostic liver biopsy and reviews the literature on procedure-associated TLS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>An 84-year-old male presented with extensive hepatic metastases and markedly elevated tumor markers. Ultrasound-guided percutaneous liver biopsy confirmed the diagnosis of metastatic adenocarcinoma. Within 24 hours post-procedure, the patient developed acute respiratory failure, anuria, severe metabolic acidosis (pH 7.23), hyperkalemia (5.5 mmol\/L), acute kidney injury (creatinine 299 \u03bcmol\/L), hyperuricemia (716 \u03bcmol\/L), and elevated lactate dehydrogenase (3953 U\/L), fulfilling the diagnostic criteria for TLS. Concurrent hemothorax occurred. Continuous renal replacement therapy (CRRT) achieved rapid correction of metabolic derangements, with parameters returning to normal within seven days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Diagnostic liver biopsy can induce STLS in patients with high-burden solid tumors. Our systematic analysis reveals that minimally invasive procedures may precipitate TLS, emphasizing the importance of prophylactic measures, early recognition, and immediate CRRT initiation for optimal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1683025","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T05:20:01Z","timestamp":1762924801000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Spontaneous tumor lysis syndrome following liver biopsy: a case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Wenchao","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41572-024-00542-w","article-title":"Tumour lysis syndrome","volume":"10","author":"Howard","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"B2","doi-asserted-by":"publisher","first-page":"102603","DOI":"10.1016\/j.ctrv.2023.102603","article-title":"Expert consensus guidelines for the prophylaxis and management of tumor lysis syndrome in the United States: Results of a modified Delphi panel","volume":"120","author":"Perissinotti","year":"2023","journal-title":"Cancer Treat Rev"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1234677","article-title":"Benefit of continuous kidney replacement therapy for managing tumor lysis syndrome in children with hematologic Malignancies","volume":"13","author":"Anderson","year":"2023","journal-title":"Front Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12415","article-title":"Tumour lysis syndrome and acute kidney injury in high-risk haematology patients in the rasburicase era. 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