{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:27:36Z","timestamp":1759364856946,"version":"build-2065373602"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Schistosomiasis is an endemic parasitic disease still prevalent in some regions of China. Chronic infection may cause recurrent inflammation and intestinal mucosal remodeling, increasing the risk of lesions such as adenomas. Although intestinal lesions associated with schistosomiasis have been reported, cases involving both the colon and appendix with egg deposition are rare. With the maturation of natural orifice transluminal endoscopic surgery (NOTES), endoscopic transcecal appendectomy (ETA), a specific NOTES technique, has been increasingly applied in clinical practice. In this case, two lesions in the colon and appendix were completely resected using endoscopic submucosal dissection (ESD) followed by ETA, offering a novel approach for the minimally invasive treatment of complex lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 77-year-old woman presented with hematochezia. Colonoscopy revealed a bulging lesion in the sigmoid colon obstructing the passage of the scope. After complete resection of the lesion by ESD, the scope was advanced to the ileocecum, where a tumor-like lesion protruding from the appendiceal orifice was identified. ETA was subsequently performed with pathologic and imaging confirmation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case suggests that Schistosoma haematobium infection may contribute to intestinal epithelial neoplasia. The combination of ESD and ETA offers a safe and feasible minimally invasive strategy for the treatment of concurrent colonic and appendiceal lesions.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1684500","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T04:17:11Z","timestamp":1759292231000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Endoscopic submucosal dissection and endoscopic transcecal appendectomy for synchronous sigmoid and appendiceal adenomas with calcified Schistosoma eggs"],"prefix":"10.3389","volume":"15","author":[{"given":"Yu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duoshan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingxing","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yemei","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoxing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"15115","DOI":"10.1038\/s41598-023-42456-9","article-title":"Clinicopathological characteristics and its association with digestive system tumors of 1111 patients with Schistosomiasis japonica","volume":"13","author":"Yang","year":"2023","journal-title":"Sci Rep"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2019.37.15_suppl.e15154","article-title":"ASQO - Advanced Support for Quality-of-life in Oncology. Clinicopathological description of a subset of schistosoma mansoni associated colorectal cancer patients in an endemic area in Brazil","volume":"37","author":"Almeida","year":"2019","journal-title":"JCO"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.18-0807","article-title":"Schistosoma japonicum\u2013associated colorectal cancer: A review","volume":"100","author":"Hamid","year":"2019","journal-title":"Am J Trop Med Hyg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"22373","DOI":"10.1038\/s41598-020-79450-4","article-title":"Schistosoma mansoni eggs induce Wnt\/\u03b2-catenin signaling and activate the protooncogene c-Jun in human and hamster colon","volume":"10","author":"Weglage","year":"2020","journal-title":"Sci Rep"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323018","article-title":"Transcolonic endoscopic appendectomy: a novel natural orifice transluminal endoscopic surgery (NOTES) technique for the sessile serrated lesions involving the appendiceal orifice","volume":"70","author":"Chen","year":"2021","journal-title":"Gut"},{"key":"B7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1055\/a-1345-0044","article-title":"Endoscopic full-thickness resection of polyps involving the appendiceal orifice: a multicenter international experience","volume":"54","author":"Ichkhanian","year":"2022","journal-title":"Endoscopy"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/den.14425","article-title":"Current status of endoscopic full-thickness resection with the full-thickness resection device","volume":"35","author":"Mueller","year":"2023","journal-title":"Dig Endosc"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1055\/a-1675-2625","article-title":"Endoscopic transcecal appendectomy: a new endotherapy for appendiceal orifice lesions","volume":"54","author":"Guo","year":"2022","journal-title":"Endoscopy"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.14744\/tjtes.2023.83357","article-title":"Comparison of ileocecal resection and right hemicolectomy in the surgical treatment of complicated appendicitis","volume":"29","author":"Turgut","year":"2023","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s00423-023-03183-x","article-title":"Preoperative scoring system for prediction of extended resection during emergency surgery for acute appendicitis","volume":"408","author":"Kobayashi","year":"2023","journal-title":"Langenbecks Arch Surg"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/wjs.12588","article-title":"Beyond appendectomy: predictive factors for major resections in adult patients with acute appendicitis","volume":"49","author":"Monrabal Lezama","year":"2025","journal-title":"World J Surg"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1055\/a-2512-3926","article-title":"Endoscopic transcecal appendectomy for a laterally spreading tumor of the appendiceal stump","volume":"57","author":"Li","year":"2025","journal-title":"Endoscopy"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.4.439","article-title":"Schistosomal colonic disease","volume":"31","author":"Mohamed","year":"1990","journal-title":"Gut"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11331","article-title":"Comparison of the clinicopathological features and prognoses of patients with schistosomal and nonschistosomal colorectal cancer","volume":"19","author":"Wang","year":"2020","journal-title":"Oncol Lett"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.10.038","article-title":"Schistosoma japonicum showing flat colon polyp appearance","volume":"73","author":"Abe","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)32747-7","article-title":"Schistosomal disease of the colon: A reversible form of polyposis","volume":"67","author":"Nebel","year":"1974","journal-title":"Gastroenterology"},{"key":"B18","first-page":"971","article-title":"Colorectal cancer and schistosomiasis","volume":"1","author":"Chen","year":"1981","journal-title":"Lancet (London England)"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1055\/a-0635-0911","article-title":"Endoscopic full-thickness resection of polyps involving the appendiceal orifice: a prospective observational case study","volume":"6","author":"Bronzwaer","year":"2018","journal-title":"Endosc Int Open"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.967100","article-title":"Colon sparing endoscopic full-thickness resection for advanced colorectal lesions: is it time for global adoption","volume":"12","author":"Wu","year":"2022","journal-title":"Front Oncol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.vgie.2018.10.001","article-title":"Endoscopic full-thickness resection of a long intussuscepted appendix by use of a colonoscope","volume":"4","author":"Hammoud","year":"2019","journal-title":"VideoGIE"},{"key":"B22","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/den.13003","article-title":"Endoscopic full-thickness resection for gastrointestinal submucosal tumors","author":"Cai","year":"2018","journal-title":"Dig Endosc"},{"key":"B23","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/den.14474","article-title":"Endoscopic full-thickness resection, indication, methods and perspectives","volume":"35","author":"Wang","year":"2023","journal-title":"Dig Endosc"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1684500\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T04:17:14Z","timestamp":1759292234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1684500\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":23,"alternative-id":["10.3389\/fonc.2025.1684500"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1684500","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"article-number":"1684500"}}