{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:10:32Z","timestamp":1785337832913,"version":"3.55.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a rare and aggressive extranodal non-Hodgkin lymphoma that predominantly affects older men and carries a relatively high risk of central nervous system (CNS) relapse. Although lumbar puncture with intrathecal prophylaxis is commonly employed to reduce CNS involvement, transient penile erection after this procedure is extraordinarily rare. This case report describes a 51-year-old man diagnosed with PT-DLBCL (stage IA) who underwent right radical orchiectomy, followed by six cycles of R2-CHOP chemotherapy with intrathecal prophylaxis prior to each cycle. Approximately 30 minutes after the sixth lumbar puncture, the patient developed a transient penile erection that persisted for approximately three hours before resolving spontaneously without intervention. He later received additional cycles of R-HD-MTX and scrotal radiotherapy, and no further episodes of penile erection or disease recurrence were observed. This clinical vignette highlights the potential for rare neurogenic reflex erections associated with repeated lumbar punctures, underscoring the importance of heightened vigilance, procedural refinement, and close monitoring in patients receiving multiple intrathecal treatments.<\/jats:p>","DOI":"10.3389\/fonc.2025.1686603","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T05:22:31Z","timestamp":1762233751000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Transient penile erection following lumbar puncture with intrathecal prophylaxis in primary testicular diffuse large B-cell lymphoma: a case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Tao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"102927","DOI":"10.1016\/j.ctrv.2025.102927","article-title":"Primary testicular lymphoma","volume":"136","author":"Grainger","year":"2025","journal-title":"Cancer Treat Rev"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2012.02.005","article-title":"Primary testicular lymphoma","volume":"24","author":"Ahmad","year":"2012","journal-title":"Clin Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.94816","article-title":"Testicular lymphoma: primary and secondary involvement","author":"Medina","year":"2022","journal-title":"Lymphoma"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2017.12.001","article-title":"The pathobiology of primary testicular diffuse large B-cell lymphoma: Implications for novel therapies","volume":"32","author":"David","year":"2018","journal-title":"Blood Rev"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.4187","article-title":"First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial","volume":"29","author":"Vitolo","year":"2011","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S407837","article-title":"Real-world data analysis of survival outcomes and central nervous system relapses in testicular diffuse large B cell lymphoma","volume":"15","author":"Lee","year":"2023","journal-title":"Cancer Manag Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0733-8619(05)70368-6","article-title":"Complications of lumbar puncture","volume":"16","author":"Evans","year":"1998","journal-title":"Neurol Clin"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S2152-2650(23)01296-X","article-title":"ABCL-165 primary testicular diffuse large B-cell lymphoma: outcome with uniform treatment protocol","volume":"23","author":"Gogia","year":"2023","journal-title":"Clin Lymphoma Myeloma Leukemia"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-140797","article-title":"Intrathecal (IT) chemotherapy for central nervous system (CNS) prophylaxis in diffuse large B-cell lymphoma (DLBCL): A single centre retrospective observational study","volume":"136","author":"Attwell","year":"2020","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-024-01262-2","article-title":"Lumbar puncture complications: A review of current literature","volume":"28","author":"Reis","year":"2024","journal-title":"Curr Pain Headache Rep"},{"key":"B11","doi-asserted-by":"publisher","first-page":"446","DOI":"10.4097\/kjae.2004.47.3.446","article-title":"Anesthetic Management of the Patient with Persistent Penile Erection Developed after Spinal Anesthesia: A case report","volume":"47","author":"Go","year":"2004","journal-title":"Korean J Anesthesiology"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.52768\/2766-7820\/1418","article-title":"Intracavernosal ephedrine for management of intraoperative penile erection during urological procedure under general anesthesia","volume":"2","author":"Yadav","year":"2021","journal-title":"J Clin Images Med Case Rep"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5534\/wjmh.2016.34.1.1","article-title":"Clinical management of priapism: A review","volume":"34","author":"Shigehara","year":"2016","journal-title":"World J Mens Health"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00120-024-02338-y","volume":"63","author":"Rosellen","year":"2024","journal-title":"Urologe - 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