{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:14:23Z","timestamp":1767870863591,"version":"3.49.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Extraovarian adult granulosa cell tumors are rare. The diagnosis of extraovarian adult granulosa cell tumors is challenging. Here we presented a case of extraovarian adult granulosa cell tumor originating in the greater omentum. Along with a review of the literature, we aim to summarizes its clinicopathological features to enhance recognition of this tumor. A 55-year-old female patient presented with dull abdominal pain for 3 days. Abdominal CT revealed a soft tissue density mass in the right lower abdomen, measuring 9.0 \u00d7 6.3 \u00d7 6.0 cm. The mass demonstrated an regular contour and indistinct borders, with heterogeneous density. Histopathological examination revealed a tumor encapsulated by a fibrous capsule. The tumor cells were arranged in cords and trabeculae with a streaming pattern. Call-Exner bodies were identified. The tumor was composed of round, oval, or polygonal cells. Nuclear grooves and \u201ccoffee-bean\u201d nuclei were observed. The mitoses figures was 1 mitoses per 10 high-power fields (HPFs, 40\u00d7objective, field area = 0.237 mm\u00b2). Tumor cells were positive for \u03b1-inhibin, SF-1, FOXL2, WT-1, and Vimentin. The Ki67 proliferation index was 20%. The histological morphology and immunophenotype support the diagnosis of adult granulosa cell tumor. Furthermore, intraoperative abdominal exploration and imaging studies revealed no lesion in the uterus or bilateral adnexa. Therefore, the diagnosis of an extraovarian adult granulosa cell tumor was established. Extraovarian granulosa cell tumors occur predominantly in middle-aged women, most commonly in the retroperitoneum, and typically present as large cystic-solid masses. The diagnosis of extraovarian granulosa cell tumor requires the definitive exclusion of a primary ovarian tumor. Diagnosis primarily relies on characteristic histomorphological features supported by immunohistochemical staining, notably positivity for markers such as \u03b1-inhibin. In diagnostically challenging cases,\n                    <jats:italic>FOXL2<\/jats:italic>\n                    mutation testing can serve as a valuable ancillary tool to confirm the diagnosis. Surgical resection is the mainstay of treatment in most cases. Consequently, we recommend that all patients with primary extra-ovarian granulosa cell tumors enter a protocol of long-term surveillance, including periodic imaging and hormonal marker assessment.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2025.1689815","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:36:43Z","timestamp":1767854203000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary extraovarian adult granulosa cell tumor of the greater omentum: a case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Ying","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"B1","volume-title":"World health organisation classification of tumours of the female reproductive organs","author":"Kurman","year":"2020"},{"key":"B2","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/S0002-9378(38)90547-2","article-title":"Primary giant granulosa cell tumor o f retroperitoneal origin with development into the mesosigmoideum","volume":"36","author":"Voigt","year":"1938","journal-title":"Am J Obster Gynecol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(40)91319-9","article-title":"Intraligamentous granulosa cell tumor","volume":"40","author":"Ragins","year":"1940","journal-title":"Am J Obster Gynecol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(40)91323-0","article-title":"Extraovarian granulosa cell tumor","author":"Powell","year":"1940","journal-title":"Am J Obster Gynecol"},{"key":"B5","article-title":"Extraovarian granulosa cell tumour","volume":"41","author":"Reddy","year":"1963","journal-title":"J Ind Med Assoc"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197302)31:2<474::AID-CNCR2820310227>3.0.CO;2-R","article-title":"Theca granulosa cell tumor arising in adrenal","volume":"31","author":"Orselli","year":"1973","journal-title":"Cancer"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199704000-00017","article-title":"Extraovarian sex cord-stromal tumor: case report and review of the literature","volume":"16","author":"Keitoku","year":"1997","journal-title":"Int J Gynecol Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5375","article-title":"Extraovarian granulosa cell tumor","volume":"74","author":"Robinson","year":"1999","journal-title":"Gynecol Oncol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(200002)22:2<107::AID-DC10>3.0.CO;2-1","article-title":"Fine-needle aspiration cytology of primary granulosa cell tumor of the adrenal gland: a case report","volume":"22","author":"Coleman","year":"2000","journal-title":"Diagn Cytopathol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2001.42.3.360","article-title":"Extraovarian granulosa cell tumor","volume":"42","author":"Kim","year":"2001","journal-title":"Yonsei Med J"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.48928","article-title":"Extraovarian granulosa cell tumor","volume":"52","author":"Paul","year":"2009","journal-title":"Indian J Pathol Microbiol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/292606","article-title":"Extraovarian granulosa cell tumor of mesentery: a case report","volume":"2010","author":"Naniwadekar","year":"2010","journal-title":"Patholog Res Int"},{"key":"B13","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3834\/uij.1944-5784.2012.12.11","article-title":"Primary retroperitoneal Granulosa Cell tumor","volume":"5","author":"Al-Shraideh","year":"2012","journal-title":"UroToday Int"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-012-1019-5","article-title":"Unusual case of extraovarian granulosa cell tumor","author":"Soydinc","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B15","doi-asserted-by":"publisher","first-page":"S159","DOI":"10.1016\/j.jmig.2013.08.536","article-title":"Extraovarian Granulosa cell tumor of fallopian tube - 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