{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T05:56:09Z","timestamp":1763618169983,"version":"3.45.0"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>We present a 55-year-old non-obese female exhibiting rapidly progressive malignant acanthosis nigricans (MAN) as the initial manifestation, characterized by widespread malodorous skin lesions that preceded the eventual diagnosis of human papillomavirus 16 (HPV16)-positive, poorly differentiated cervical squamous cell carcinoma by four years. Following chemotherapy, both tumor markers and cutaneous manifestations demonstrated rapid regression. However, at the most recent follow-up (August 2025), the patient was hospitalized for management of grade 3 myelosuppression and a secondary pulmonary infection, necessitating temporary suspension of antitumor therapy. This treatment\u2013response correlation provides compelling clinical substantiation for the \u201ctumor-secretory factor-driven\u201d pathogenesis, indicating that MAN may serve as a critical early paraneoplastic signal of HPV-associated gynecologic malignancies and warrant prompt systemic screening upon its recognition.<\/jats:p>","DOI":"10.3389\/fonc.2025.1694975","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T05:11:44Z","timestamp":1763615504000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Rapid resolution of malignant acanthosis nigricans following chemotherapy for cervical 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