{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:33:37Z","timestamp":1791855217544,"version":"4.3.4"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the application value of standardized screening and risk-stratified management in the clinical practice of Oral Potentially Malignant Disorders (OPMDs) for improving early diagnosis rates and optimizing intervention strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 312 OPMD patients diagnosed between January 2017 and December 2022 were enrolled. A screening pathway of \u201cinitial screening (questionnaire + visual\/tactile examination) - refined screening (pathological biopsy)\u201d was established. Risk stratification (low, intermediate, high) was performed using a modified Proliferative Verrucous Leukoplakia (PVL)-based scoring system. Multidisciplinary team (MDT) management was implemented. Risk factors for malignant transformation were analyzed using Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The high-risk group had a significantly higher malignant transformation rate than the intermediate and low-risk groups (12.5% vs. 3.5% vs. 0%, P&amp;lt;0.001), with a shorter median time to transformation (23.4 months). Severe epithelial dysplasia (HR = 6.24), lesions located in the tongue ventral\/floor of mouth (HR = 3.34), and betel quid chewing history (HR = 2.62) were identified as independent risk factors. The MDT model achieved a 2-year cancer-free survival rate of 91.4% in high-risk patients and improved follow-up compliance to 83.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An OPMD management model based on risk stratification and MDT collaboration can effectively identify high-risk patients, optimize intervention timing, and improve prognosis. This model is suitable for promotion in primary care hospitals.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1697676","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T04:17:43Z","timestamp":1759897063000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical practice of early screening and risk-stratified management for oral potentially malignant disorders"],"prefix":"10.3389","volume":"15","author":[{"given":"Beibei","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meimei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxin","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"Ferlay","year":"2019","journal-title":"Int J Cancer"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.03.009","article-title":"Oral cancer: clinical features","volume":"46","author":"Bagan","year":"2010","journal-title":"Oral Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"105451","DOI":"10.1016\/j.oraloncology.2021.105451","article-title":"Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics","volume":"121","author":"Chamoli","year":"2021","journal-title":"Oral Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26107","article-title":"Risk of second primary cancer in oral squamous cell carcinoma","volume":"42","author":"Mroueh","year":"2020","journal-title":"Head Neck"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.aodf.2007.10.014","article-title":"Tissue biomarkers for diagnosis & management of oral squamous cell carcinoma","volume":"100","author":"D\u2019Silva","year":"2007","journal-title":"Alpha Omegan"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2021.1898949","article-title":"Oral Potentially Malignant Disorders (OPMD): What is the clinical utility of dysplasia grade","volume":"21","author":"Pritzker","year":"2021","journal-title":"Expert Rev Mol Diagn"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.03.011","article-title":"Clinical features and presentation of oral potentially Malignant disorders","volume":"125","author":"Warnakulasuriya","year":"2018","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_116_18","article-title":"Epidemiological profile and clinical characteristics of oral potentially Malignant disorders and oral squamous cell carcinoma: A pilot study in Bidar and Gulbarga Districts, Karnataka, India","volume":"23","author":"Kumar","year":"2019","journal-title":"J Oral Maxillofac Pathol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-020-01262-9","article-title":"Proliferative verrucous leukoplakia: an expert consensus guideline for standardized assessment and reporting","volume":"15","author":"Thompson","year":"2021","journal-title":"Head Neck Pathol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"9160","DOI":"10.3390\/ijerph17249160","article-title":"Oral cancer and precancer: A narrative review on the relevance of early diagnosis","volume":"17","author":"Abati","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-017-1161-y","article-title":"Role of toluidine blue staining in suspicious lesions of oral cavity and oropharynx","volume":"71","author":"Vijayakumar","year":"2019","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.jomfp_332_24","article-title":"Liquid-based cytology in the diagnosis of oral pre-cancer, cancer, and other oral lesions - 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