{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T07:09:32Z","timestamp":1765782572506,"version":"3.48.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Primary extranodal diffuse large B-cell lymphoma (PE-DLBCL) originates in extranodal organs and accounts for approximately 30%\u201340% of all DLBCL cases. PE-DLBCL involving multiple organs without lymph node involvement is uncommon. We present a case of DLBCL in a patient who initially presented with abdominal pain. Abdominal computed tomography (CT) revealed suspicious neoplastic lesions in the liver and ileum. Histopathological examination of an ileal biopsy confirmed the diagnosis of DLBCL. The patient subsequently underwent [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT for disease staging. PET\/CT demonstrated multiple hypermetabolic lesions in the liver, right kidney, and ileum, notably in the absence of any lymph node involvement throughout the body. After four cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy, [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT evaluation revealed significant shrinkage of the abdominal lesions, indicating a favorable prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This case demonstrates a rare presentation of multisystem PE-DLBCL without lymphadenopathy and underscores the vital role of [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET\/CT in identifying disease extent and guiding accurate staging and management, as well as evaluating treatment response.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1697944","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T07:05:33Z","timestamp":1765782333000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["[18F]FDG PET\/CT detection and therapeutic response assessment of primary multisystem extranodal diffuse large B-cell lymphoma without lymph node involvement: a case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Taiping","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.11.003","article-title":"Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma [published correction appears in Cancer Cell","volume":"24","author":"Chapuy","year":"2013","journal-title":"Cancer Cell"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn525","article-title":"Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management","volume":"19","author":"Psyrri","year":"2008","journal-title":"Ann Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012057","article-title":"Primary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC","volume":"140","author":"Olsen","year":"2022","journal-title":"Blood"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.2283","article-title":"Primary breast lymphoma: 30 years of experience with diagnosis and treatment at a single medical center","volume":"149","author":"Radkani","year":"2014","journal-title":"JAMA Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41572-023-00439-0","article-title":"Primary central nervous system lymphoma","volume":"9","author":"Ferreri","year":"2023","journal-title":"Nat Rev Dis Prime"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1967\/s002449912439","article-title":"A rare involvement of diffuse large B-cell lymphoma: Peritoneal lymphomatosis with a peritoneal super-scan appearance on 18F-FDG PET\/CT","volume":"25","author":"Y\u0131lmaz","year":"2022","journal-title":"Hell J Nucl Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"v91","DOI":"10.1093\/annonc\/mdw175","article-title":"Extranodal diffuse large B-cell lymphoma (DLBCL) and primary mediastinal B-cell lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"27","author":"Vitolo","year":"2016","journal-title":"Ann Oncol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.14740\/jh984","article-title":"Site-specific survival of extra nodal diffuse large B-cell lymphoma and comparison with gastrointestinal diffuse large B-cell lymphoma","volume":"11","author":"Gupta","year":"2022","journal-title":"J Hematol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4103\/ijc.IJC_450_16","article-title":"Diffuse large B-cell lymphoma: A retrospective study from a regional care center in South India","volume":"55","author":"Babu","year":"2018","journal-title":"Indian J Can"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.10-9-734","article-title":"Multifocal extranodal non-hodgkin lymphoma: a clinicopathologic study of 37 cases in Greece, a Hellenic Cooperative Oncology Group study","volume":"10","author":"Economopoulos","year":"2005","journal-title":"Oncologist"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.24875\/RIC.19003027","article-title":"Clinical characteristics of primary extranodal versus nodal diffuse large b-cell lymphoma: a retrospective cohort study in a cancer center","volume":"71","author":"Candelaria","year":"2019","journal-title":"Rev Invest Clin"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.70033","article-title":"Extranodal diffuse large B-cell lymphoma: Clinical and molecular insights with survival outcomes from the multicenter EXPECT study","volume":"45","author":"Chen","year":"2025","journal-title":"Cancer Commun (Lond)"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.4103\/wjnm.WJNM_111_20","article-title":"Bilateral renal involvement in diffuse large B-cell lymphoma on fluorodeoxyglucose positron emission tomography\/computed tomography","volume":"20","author":"Benameur","year":"2021","journal-title":"World J Nucl Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4274\/mirt.galenos.2021.28190","article-title":"Diffuse large B-cell non-hodgkin lymphoma involving multiple different organs in a young adult with 18F-FDG PET\/CT","volume":"31","author":"Arslan","year":"2022","journal-title":"Mol Imaging Radionucl Ther"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800","article-title":"Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification","volume":"32","author":"Cheson","year":"2014","journal-title":"J Clin Oncol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.124.268874","article-title":"PET-based risk stratification in primary mediastinal B-cell lymphoma: A comparative analysis of different segmentation methods in the IELSG37 trial patient cohort","volume":"66","author":"Ceriani","year":"2025","journal-title":"J Nucl Med"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04286-8","article-title":"Baseline PET features to predict prognosis in primary mediastinal B cell lymphoma: a comparative analysis of different methods for measuring baseline metabolic tumour volume","volume":"46","author":"Ceriani","year":"2019","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1539-5","article-title":"Diagnostic and prognostic impact of 18F-FDG PET\/CT in follicular lymphoma","volume":"37","author":"Le Dortz","year":"2010","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp030","article-title":"High SUV uptake on FDG-PET\/CT predicts for an aggressive B-cell lymphoma in a prospective study of primary FDG-PET\/CT staging in lymphoma","volume":"20","author":"Ngeow","year":"2009","journal-title":"Ann Oncol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.blre.2016.09.004","article-title":"High grade B-cell lymphoma with rearrangements of MYC and BCL2 and\/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma","volume":"31","author":"Rosenthal","year":"2017","journal-title":"Blood Rev"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04666-0","article-title":"Extranodal involvement of multiple organs in diffuse large B cell lymphoma detected on 18F-FDG PET\/CT","volume":"47","author":"Song","year":"2020","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-012-0183-3","article-title":"Extensive extranodal involvement of rare sites in non hodgkin\u2019s lymphoma detected on (18)F- FDG PET-CT: A case report","volume":"47","author":"Dhull","year":"2013","journal-title":"Nucl Med Mol Imag"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000005108","article-title":"Unusual presence of synchronous primary ovarian and thyroid extranodal non-hodgkin lymphoma without lymph node involvement","volume":"49","author":"Babacan","year":"2024","journal-title":"Clin Nucl Med"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1697944\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T07:05:34Z","timestamp":1765782334000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1697944\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":23,"alternative-id":["10.3389\/fonc.2025.1697944"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1697944","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"article-number":"1697944"}}