{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:38:48Z","timestamp":1771922328433,"version":"3.50.1"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epithelial-myoepithelial carcinoma (EMCa) is a low-grade malignant tumor that occurs primarily in the salivary glands. Its occurrence in the nasopharynx is exceedingly rare. Due to its scarcity, there is currently a lack of standardized treatment protocols, and robust prognostic data remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report a case series of two patients with histopathologically confirmed nasopharyngeal EMCa, supplemented by a systematic literature review to summarize its clinicopathological characteristics, treatment modalities, and prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The two cases exhibited strikingly divergent outcomes. The first patient (Case 1) underwent surgical resection followed by adjuvant radiotherapy, achieving a complete clinical response and remaining disease-free at 31 months. In contrast, the second patient (Case 2) presented a markedly more aggressive profile, characterized by younger age, neurological symptoms, and an atypically high\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG uptake on PET\/CT, a notable deviation from the typically non-significant avidity reported for EMCa. Despite aggressive multimodal therapy, the disease progressed rapidly with extensive metastases. Subsequent institution of a combined chemotherapy and immunotherapy regimen successfully achieved disease stabilization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our cases illustrate the heterogeneous clinical behavior of nasopharyngeal EMCa, ranging from indolent disease to aggressive progression. Our observations suggest that high\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG uptake may serve as a critical biomarker for an aggressive phenotype. Given this variability, individualized treatment strategies may be warranted, and further studies are needed to better define optimal management for this rare tumor.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2025.1720988","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T05:21:51Z","timestamp":1768540911000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epithelial-myoepithelial carcinoma of the nasopharynx: cases report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Wenju","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center & State Key Laboratory of Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NaNa","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Chengdu First People\u2019s Hospital","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongzheng","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center & State Key Laboratory of Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center & State Key Laboratory of Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center & State Key Laboratory of Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyuan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center & State Key Laboratory of Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zelei","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center & State Key Laboratory of Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenfeng","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center & State Key Laboratory of Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center & State Key Laboratory of Biotherapy, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.4103\/2231-0746.133085","article-title":"Epithelial-myoepithelial carcinoma of the parotid gland: Clinicopathological aspect, diagnosis and surgical consideration","volume":"4","author":"Politi","year":"2014","journal-title":"Ann Maxillofac Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/01.pas.0000213314.74423.d8","article-title":"Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract","volume":"31","author":"Seethala","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815594788","article-title":"Epithelial-myoepithelial carcinoma of the salivary glands: an analysis of 246 cases","volume":"153","author":"V\u00e1zquez","year":"2015","journal-title":"Otolaryngol Neck Surg"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022671","article-title":"Clinical and pathological analysis of 10 cases of salivary gland epithelial-myoepithelial carcinoma","volume":"99","author":"Wang","year":"2020","journal-title":"Med (Baltimore)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/BF00543554","article-title":"Diagnosis and ultrastructure of the tubular carcinoma of salivary gland ducts. 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