{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T07:53:32Z","timestamp":1785398012696,"version":"3.56.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Retroperitoneal dedifferentiated liposarcoma (RP DDLS) is considered highly malignant, with a high recurrence rate and poor prognosis, and is usually asymptomatic until the advanced stages. Retroperitoneal liposarcoma with colon invasion is extremely rare, with only a few cases reported in the literature. This study reported the case of a 75-year-old male patient with a retroperitoneal space-occupying lesion without any clinical symptoms. Abdominal computed tomography (CT) and magnetic resonance imaging (MRI) scans suggested a neoplastic lesion. After adequate preoperative preparation, the patient underwent laparoscopic tumor resection and right hemicolectomy. Pathological and immunohistochemical examinations of the resected retroperitoneal mass and right hemicolon revealed dedifferentiated liposarcoma (DDLPS). Dedifferentiated liposarcomas are characterized by local invasiveness and a high recurrence rate. The association between dedifferentiated liposarcoma and invasive behavior observed in this patient underscores the importance of multidisciplinary collaboration as the primary treatment strategy. Nevertheless, complete tumor resection remains crucial for improving the prognosis and reducing the high local recurrence rate.<\/jats:p>","DOI":"10.3389\/fonc.2025.1724071","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:25:41Z","timestamp":1765344341000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Retroperitoneal dedifferentiated liposarcoma with colon infiltration: a case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Xi","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyao","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyou","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31829b5667","article-title":"Retroperitoneal liposarcoma: a comprehensive review","volume":"38","author":"Vijay","year":"2015","journal-title":"Am J Clin Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1067\/j.cpsurg.2009.01.004","article-title":"Retroperitoneal and intra-abdominal sarcoma","volume":"6","author":"Liles","year":"2009","journal-title":"Curr Probl Surg"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-018-2777-3","article-title":"Primary anatomical site, adjuvant therapy, and other prognostic variables for dedifferentiated liposarcoma","volume":"145","author":"Gootee","year":"2019","journal-title":"J Cancer Res Clin Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq238","article-title":"Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French sarcoma group database","volume":"21","author":"Italiano","year":"2010","journal-title":"Ann Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.annonc.2021.08.2155","article-title":"Precision guidelines for soft tissue and visceral sarcomas: the evidence, expert experience and ensuring optimal care for rare cancers, a 2021 update from ESMO\u2013EURACAN\u2013GENTURIS","volume":"32","author":"Gladdy","year":"2021","journal-title":"Ann Oncol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.juro.2006.12.006","article-title":"Retroperitoneal liposarcoma","volume":"177","author":"Chouairy","year":"2007","journal-title":"J Urol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.07.006","article-title":"Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"32","author":"Gronchi","year":"2021","journal-title":"Ann Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00411-012-0405-1","article-title":"Computed tomographies and cancer risk in children: a literature overview of CT practices, risk estimations and an epidemiologic cohort study proposal","volume":"51","author":"Krille","year":"2012","journal-title":"Radiat Environ Biophys"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2022.03.001","article-title":"WHO Pathology: Highlights of the 2020 sarcoma update","volume":"31","author":"Schaefer","year":"2022","journal-title":"Surg Oncol Clin N Am"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000086542.11899.38","article-title":"Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma","volume":"238","author":"Singer","year":"2003","journal-title":"Ann Surg"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153230","article-title":"Biology and management of dedifferentiated liposarcoma: state of the art and perspectives","volume":"10","author":"Nishio","year":"2021","journal-title":"J Clin Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-000-0535-6","article-title":"Clinico-pathological data and prognostic factors in completely resected AJCC stage I-III liposarcomas","volume":"7","author":"Nijhuis","year":"2000","journal-title":"Ann Surg Oncol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174331","article-title":"Comparing apparent diffusion coefficient and FNCLCC grading to improve pretreatment grading of soft tissue sarcoma-a translational feasibility study on fusion imaging","volume":"14","author":"Hettler","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.62347\/FQAD9826","article-title":"Prognostic factors in retroperitoneal liposarcoma after R0 resection: a study of age, histologic type, tumor stage, and differentiation grade","volume":"17","author":"Zou","year":"2025","journal-title":"Am J Transl Res"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24045","article-title":"Computed tomography scan-driven selection of treatment for retroperitoneal liposarcoma histologic subtypes","volume":"115","author":"Lahat","year":"2009","journal-title":"Cancer"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0253-3766.2019.03.013","article-title":"Comparison of imaging and pathologic findings of retroperitoneal dedifferentiated liposarcoma","volume":"41","author":"Zhang","year":"2019","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7594027","article-title":"Diagnosis and prognosis of retroperitoneal liposarcoma: A single asian center cohort of 57 cases","volume":"2021","author":"Xiao","year":"2021","journal-title":"J Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2015.00004","article-title":"Retroperitoneal liposarcoma: current insights in diagnosis and treatment","volume":"2","author":"Matthyssens","year":"2015","journal-title":"Front Surg"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3180581fff","article-title":"Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR","volume":"31","author":"Sirvent","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e92d0b","article-title":"Molecular testing for lipomatous tumors: critical analysis and test recommendations based on the analysis of 405 extremity-based tumors","volume":"34","author":"Zhang","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182417330","article-title":"Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors","volume":"36","author":"Thway","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2009.070201","article-title":"Can MDM2 and CDK4 make the diagnosis of well differentiated\/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours","volume":"62","author":"Aleixo","year":"2009","journal-title":"J Clin Pathol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s12957-020-02069-2","article-title":"Perioperative strategy and outcome in giant retroperitoneal dedifferentiated liposarcoma-results of a retrospective cohort study","volume":"18","author":"Bachmann","year":"2020","journal-title":"World J Surg Oncol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0b013e3181b2468b","article-title":"Predicting outcome by growth rate of locally recurrent retroperitoneal liposarcoma: the one centimeter per month rule","volume":"250","author":"Park","year":"2009","journal-title":"Ann Surg"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i25.4045","article-title":"Recurrent abdominal liposarcoma: analysis of 19 cases and prognostic factors","volume":"19","author":"Lu","year":"2013","journal-title":"World J Gastroenterol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s12957-018-1505-4","article-title":"Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma","volume":"16","author":"Nathenson","year":"2018","journal-title":"World J Surg Oncol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s13014-021-01774-w","article-title":"Adjuvant therapy for retroperitoneal sarcoma: a meta-analysis","volume":"16","author":"Li","year":"2021","journal-title":"Radiat Oncol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23463","article-title":"Management of recurrent retroperitoneal sarcoma","volume":"109","author":"Gyorki","year":"2014","journal-title":"J Surg Oncol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2022.06.008","article-title":"Management of recurrent retroperitoneal sarcomas","volume":"49","author":"Siew","year":"2023","journal-title":"Eur J Surg Oncol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1080\/13577140020008066","article-title":"Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft-tissue sarcoma: A meta-analysis and clinical practice guideline","volume":"4","author":"Bramwell","year":"2000","journal-title":"Sarcoma"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1038\/s41598-024-84247-w","article-title":"Cost-effectiveness analysis of eribulin versus dacarbazine in patients with advanced liposarcoma","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci Rep"},{"key":"B32","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s13046-021-01963-1","article-title":"The potential role of the extracellular matrix in the activity of trabectedin in ups and L-sarcoma: evidences from a patient-derived primary culture case series in tridimensional and zebrafish models","volume":"40","author":"De Vita","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyu009","article-title":"Retroperitoneal liposarcoma with colonic involvement: a case report","volume":"44","author":"Sato","year":"2014","journal-title":"Jpn J Clin Oncol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.7205\/milmed-d-01-9608","article-title":"Dedifferentiated retroperitoneal liposarcoma presenting as lower gastrointestinal bleeding, a case report and review of the literature","volume":"174","author":"Wanchick","year":"2009","journal-title":"Mil Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e245595","DOI":"10.1136\/bcr-2021-245595","article-title":"Ischaemic colitis secondary to retroperitoneal liposarcoma","volume":"14","author":"Goh","year":"2021","journal-title":"BMJ Case Rep"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2025.111142","article-title":"Giant retroperitoneal liposarcoma with colonic infiltration as a cause of gastrointestinal bleeding: Case report and literature review","volume":"129","author":"Forero-Escobedo","year":"2025","journal-title":"Int J Surg Case Rep"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1724071\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:25:42Z","timestamp":1765344342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1724071\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":36,"alternative-id":["10.3389\/fonc.2025.1724071"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1724071","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"article-number":"1724071"}}