{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T06:39:55Z","timestamp":1777012795444,"version":"3.51.4"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>This article presents a successful case of endoscopic-assisted intrathecal morphine pump implantation for the treatment of cancer pain associated with bone metastases. The patient was a 45-year-old female with severe cancer pain resulting from multiple bone metastases of rectal malignancy, which was poorly managed by the traditional three-step analgesic ladder. Preoperative intrathecal test puncture was attempted at multiple spinal levels but failed to access the intrathecal space. Subsequently, an endoscopic-assisted intrathecal morphine pump implantation was successfully performed at the L5-S1 level. Postoperatively, the patient achieved marked and sustained pain relief, accompanied by a dramatic improvement in her quality of life. No significant complications were observed during a 6-month follow-up. This technique provides a new therapeutic option for cancer pain patients who encounter difficulties with standard pump implantation procedures, demonstrating considerable potential for clinical application.<\/jats:p>","DOI":"10.3389\/fonc.2026.1618305","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:49:18Z","timestamp":1777009758000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopy-assisted intrathecal morphine pump implantation for severe cancer pain: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Yun","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Pain, The Affiliated Hospital of Jiujiang University","place":["Jiujiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanying","family":"Yu","sequence":"additional","affiliation":[{"name":"Hospital Infection Management Department, The Affiliated Hospital of Jiujiang University","place":["Jiujiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaifeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pain, The Affiliated Hospital of Jiujiang University","place":["Jiujiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pain, The Affiliated Hospital of Jiujiang University","place":["Jiujiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinqin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pain, The Affiliated Hospital of Jiujiang University","place":["Jiujiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liusheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pain, The Affiliated Hospital of Jiujiang University","place":["Jiujiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pain, The Affiliated Hospital of Jiujiang University","place":["Jiujiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pain, The Affiliated Hospital of Jiujiang University","place":["Jiujiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00073-1","article-title":"An international survey of cancer pain characteristics and syndromes","volume":"82","author":"Caraceni","year":"1999","journal-title":"Pain"},{"key":"B2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/j.pain.0000000000001363","article-title":"The IASP classification of chronic pain for ICD-11: chronic cancer-related pain","volume":"160","author":"Bennett","year":"2019","journal-title":"Pain"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2019.07.09","article-title":"Multiple bone metastases: what the palliative care specialist should know about the potential, limitations and practical aspects of radiation therapy","volume":"9","author":"Tsao","year":"2020","journal-title":"Ann Palliat Med"},{"key":"B4","volume-title":"WHO guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents","year":"2018"},{"key":"B5","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/ner.12538","article-title":"The polyanalgesic consensus conference (PACC): recommendations on intrathecal drug infusion systems best practices and guidelines","volume":"20","author":"Deer","year":"2017","journal-title":"Neuromodulation"},{"key":"B6","article-title":"Intrathecal therapy for cancer-related pain","volume":"17","author":"Hayek","year":"2016","journal-title":"Pain Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1533-2500.2009.00311.x","article-title":"Incidence and severity of epidural fibrosis after back surgery: an endoscopic study","volume":"10","author":"Bosscher","year":"2010","journal-title":"Pain Pract"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58030371","article-title":"Six revision surgeries for massive epidural fibrosis with recurrent pain and weakness in the left lower extremity","volume":"58","author":"Choi","year":"2022","journal-title":"Med (Kaunas)"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13464","article-title":"Dura fistula: a rare complication of simultaneous placement of neurostimulation leads and an intrathecal catheter","volume":"26","author":"Dupoiron","year":"2023","journal-title":"Neuromodulation"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12693","article-title":"Intrathecal therapeutics: device design, access methods, and complication mitigation","volume":"21","author":"Nagel","year":"2018","journal-title":"Neuromodulation"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-065846","article-title":"Full endoscopic versus open discectomy for sciatica: randomised controlled non-inferiority trial","volume":"376","author":"Gadjradj","year":"2022","journal-title":"BMJ"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.14444\/8458","article-title":"Full-endoscopic lumbar discectomy vs standard discectomy: a noninferiority study on clinically relevant changes","volume":"17","author":"Beck","year":"2023","journal-title":"Int J Spine Surg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"E91","DOI":"10.1097\/BRS.0000000000001161","article-title":"Minimally invasive versus open laminectomy for lumbar stenosis: a systematic review and meta-analysis","volume":"41","author":"Phan","year":"2016","journal-title":"Spine (Phila Pa 1976)"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1618305\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:49:18Z","timestamp":1777009758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1618305\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":13,"alternative-id":["10.3389\/fonc.2026.1618305"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1618305","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"article-number":"1618305"}}