{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:03:57Z","timestamp":1771927437164,"version":"3.50.1"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou Municipality","doi-asserted-by":"publisher","award":["Y20220819, Y2023849"],"award-info":[{"award-number":["Y20220819, Y2023849"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The etiology of hypoglossal nerve palsy is diverse, including trauma, infection, tumors, endocrine disorders, autoimmune diseases, and vascular lesions. Tumors in the jugular foramen region are rare and primarily include paragangliomas, schwannomas, or meningiomas. Isolated hypoglossal nerve palsy caused by a jugular foramen tumor is exceedingly rare. This report presents a unique case of a jugular foramen tumor leading to isolated hypoglossal nerve injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 39-year-old male with no significant medical history presented with a two-week history of headache and 10 days of leftward tongue deviation. Physical examination revealed leftward tongue deviation with mild dysarthria. Nasopharyngoscopy and routine laboratory tests yielded normal results. Lumbar puncture and next-generation sequencing (NGS) ruled out intracranial infection. MRI showed a 6.0\u00d79.0 mm nodule in the left jugular foramen, hyperintense on T2-weighted imaging, isointense on DWI, and exhibiting ring-like enhancement on contrast MRI. A jugular foramen tumor was suspected, and surgical resection was recommended. However, the patient opted for gamma knife treatment at another hospital, resulting in symptom improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and conclusion<\/jats:title>\n                    <jats:p>Multisequence MRI confirmed compression of the hypoglossal nerve by a left jugular foramen tumor. This case is unique in that the tumor, despite its location, manifested solely as hypoglossal nerve palsy, an atypical presentation that can lead to misdiagnosis. This case report highlights the importance of high-resolution imaging and multidisciplinary collaboration in diagnosing skull base lesions and explores the anatomical relationship between the hypoglossal nerve and jugular foramen in disease pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1635494","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:18:56Z","timestamp":1769411936000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Jugular foramen tumor causing isolated hypoglossal nerve palsy: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhijun","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youcheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Imaging, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yirui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine","place":["Wenzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-4356(95)90292-9","article-title":"Traumatic isolated unilateral hypoglossal nerve palsy\u2013case report and review of the literature","volume":"33","author":"Castling","year":"1995","journal-title":"Br J Oral Maxillofac Surg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pjnns.2018.06.006","article-title":"Hypoglossal nerve palsy as an isolated syndrome of internal carotid artery dissection: A review of the literature and a case report","volume":"52","author":"Mes","year":"2018","journal-title":"Neurol Neurochir Pol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1186\/s12883-022-02929-2","article-title":"Hypoglossal nerve palsy after SARS-CoV-2 vaccination - 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