{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:38:43Z","timestamp":1777354723912,"version":"3.51.4"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Pseudomyogenic hemangioendothelioma (PHE) is a rare vascular neoplasm predominantly affecting young adult males, often presenting in soft tissues of the extremities, with exceptionally rare cases in the penile region. This report details the case of a 45-year-old Han Chinese male with a painful penile nodule misdiagnosed as Peyronie\u2019s disease due to its clinical presentation. Initial evaluations, including ultrasound and laboratory tests, suggested uncertainty regarding the lesion\u2019s nature. Surgical excision was performed, revealing a dark purplish-red mass embedded in the tunica albuginea. Histopathological analysis supported a diagnosis of PHE, highlighted by immunohistochemical markers including strong positivity for FOSB and CD31. The postoperative course demonstrated good recovery and resolution of symptoms with no recurrence observed during follow-up. This case emphasizes the diagnostic challenge posed by PHE due to its deceptive clinical features and the necessity for histopathological examination coupled with immunophenotypic profiling for accurate diagnosis. Increased awareness of PHE is crucial for urologists and andrologists to improve diagnostic accuracy and facilitate timely management of this rare entity.<\/jats:p>","DOI":"10.3389\/fonc.2026.1649382","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:40:28Z","timestamp":1777351228000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Penile pseudomyogenic hemangioendothelioma\/epithelioid sarcoma-like hemangioendothelioma: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology, Tianjin First Central Hospital, No.2 Baoshan West Road, Xiqing District","place":["Tianjin, China"]},{"name":"Department of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Urology, People's Hospital of Linshui, No. 487, Renmin North Road, Linshui County","place":["Guangan, Sichuan, China"]},{"name":"Department of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haozhou","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology, Fushun People's Hospital, No. 490, Jixiang Road, Fushun County","place":["Zigong, Sichuan, China"]},{"name":"Department of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Urology, Dianjiang Traditional Chinese Medicine Hospital, No. 502, Gongnong Road, Dianjiang County","place":["Chongqing, China"]},{"name":"Department of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology, People's Hospital of Luxian, No. 628 Longnao Avenue","place":["Luxian, Luzhou, Sichuan, China"]},{"name":"Department of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Andrology, No.2 People's Hospital of Fuyang, No. 1088, Yinghe West Road, Yingquan District","place":["Fuyang, Anhui, China"]},{"name":"Department of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15353","article-title":"Pseudomyogenic hemangioendothelioma in the external genitalia","volume":"22","author":"Zhou","year":"2024","journal-title":"J Dtsch Dermatol Ges"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-024-03944-z","article-title":"Pseudomyogenic hemangioendothelioma presenting as a penile lesion","volume":"485","author":"Youssef","year":"2024","journal-title":"Virchows Arch"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920315)69:6<1382::aid-cncr2820690614>3.0.co;2-y","article-title":"The fibroma-like variant of epithelioid sarcoma. A fibrohistiocytic\/myoid cell lesion often confused with benign and Malignant spindle cell tumors","volume":"69","author":"Mirra","year":"1992","journal-title":"Cancer"},{"key":"B4","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/00000478-200301000-00006","article-title":"Epithelioid sarcoma-like hemangioendothelioma","volume":"27","author":"Billings","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"B5","article-title":"Pseudomyogenic haemangioendothelioma","volume-title":"Pathology and Genetics of Tumours of Soft Tissueand Bone","author":"Hornick","year":"2013"},{"key":"B6","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1097\/PAS.0b013e3181ff0901","article-title":"Pseudomyogenic hemangioendothelioma: a distinctive, often multicentric tumor with indolent behavior","volume":"35","author":"Hornick","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13000-023-01309-9","article-title":"Clinicopathological study of pseudomyogenic hemangioendothelioma","volume":"18","author":"Yang","year":"2023","journal-title":"Diagn Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0395-rs","article-title":"Pseudomyogenic hemangioendothelioma (Epithelioid sarcoma-like hemangioendothelioma)","volume":"144","author":"Caballero","year":"2020","journal-title":"Arch Pathol Lab Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1097\/pas.0000000000000795","article-title":"FOSB is a useful diagnostic marker for pseudomyogenic hemangioendothelioma","volume":"41","author":"Hung","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2011.01.002","article-title":"Translocation t(7;19)(q22;q13)-a recurrent chromosome aberration in pseudomyogenic hemangioendothelioma","volume":"204","author":"Trombetta","year":"2011","journal-title":"Cancer Genet"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22206","article-title":"ZFP36-FOSB fusion defines a subset of epithelioid hemangioma with atypical features","volume":"53","author":"Antonescu","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2015.02.003","article-title":"Penile pseudomyogenic hemangioendothelioma\/epithelioid sarcoma-like hemangioendothelioma with a novel pattern of SERPINE1-FOSB fusion detected by RT-PCR--report of a case","volume":"211","author":"Ide","year":"2015","journal-title":"Pathol Res Pract"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.92852","article-title":"Penile pseudomyogenic hemangioendothelioma: diagnostic and therapeutic considerations","volume":"17","author":"Nsair","year":"2025","journal-title":"Cureus"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1649382\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:40:43Z","timestamp":1777351243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1649382\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":13,"alternative-id":["10.3389\/fonc.2026.1649382"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1649382","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"article-number":"1649382"}}