{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:37:59Z","timestamp":1772087879109,"version":"3.50.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    The\n                    <jats:italic>KMT2A<\/jats:italic>\n                    gene, located at chromosome band 11q23, encodes a lysine methyltransferase essential for hematopoietic gene regulation. While\n                    <jats:italic>KMT2A<\/jats:italic>\n                    rearrangements are common in acute myeloid leukemia (AML) and B-cell acute lymphoblastic leukemia (B-ALL),\n                    <jats:italic>KMT2A<\/jats:italic>\n                    amplification is rare, occurring in ~1% of AML cases and even less frequently in B-ALL. Given its rarity, understanding\n                    <jats:italic>KMT2A<\/jats:italic>\n                    amplification in B-ALL is crucial for improving diagnostics and therapy. We report two adult B-ALL cases with\n                    <jats:italic>KMT2A<\/jats:italic>\n                    amplification. Patient 1, a 58-year-old male, had\n                    <jats:italic>KMT2A<\/jats:italic>\n                    amplification (6~18 copies in 68.5% of bone marrow cells), a complex karyotype, and a pathogenic\n                    <jats:italic>TP53<\/jats:italic>\n                    variant (c.524G&amp;gt;A, p.Arg175His). He underwent induction chemotherapy but passed away after two months due to complications. Patient 2, a 66-year-old female, had\n                    <jats:italic>KMT2A<\/jats:italic>\n                    amplification (8~11 copies in 87.5% of peripheral blood cells) and\n                    <jats:italic>CRLF2<\/jats:italic>\n                    rearrangement, representing the first reported case of\n                    <jats:italic>de novo<\/jats:italic>\n                    Ph-like B-ALL with\n                    <jats:italic>KMT2A<\/jats:italic>\n                    amplification in an adult. She deteriorated rapidly and died within four days. In addition to these two cases from our cohort, we review nine published cases with\n                    <jats:italic>KMT2A<\/jats:italic>\n                    amplification in B-ALL, which showed frequent\n                    <jats:italic>TP53<\/jats:italic>\n                    alterations, emphasizing the clinical and genetic characteristics of this aggressive leukemia subtype. These cases highlight the high-risk nature of\n                    <jats:italic>KMT2A<\/jats:italic>\n                    -amplified B-ALL, particularly in older adults, where prognosis is poor and linked to\n                    <jats:italic>TP53<\/jats:italic>\n                    variants or\n                    <jats:italic>CRLF2<\/jats:italic>\n                    rearrangement. Our review underscores the need for genetic profiling to improve risk stratification and treatment. Given the limited documented cases, further research is essential to develop better therapeutic strategies for\n                    <jats:italic>KMT2A<\/jats:italic>\n                    -amplified B-ALL.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1656404","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:29:33Z","timestamp":1772083773000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: KMT2A amplification in two adult patients with B-cell acute lymphoblastic leukemia"],"prefix":"10.3389","volume":"16","author":[{"given":"Min","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Genetics, University of Alabama at Birmingham","place":["Birmingham, AL, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunjia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Alabama at Birmingham","place":["Birmingham, AL, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimo","family":"Bachiashvili","sequence":"additional","affiliation":[{"name":"Department of Medicine (Hematology\/Oncology), University of Alabama at Birmingham","place":["Birmingham, AL, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankit J.","family":"Vachhani","sequence":"additional","affiliation":[{"name":"Department of Medicine (Hematology\/Oncology), University of Alabama at Birmingham","place":["Birmingham, AL, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Jamy","sequence":"additional","affiliation":[{"name":"Department of Medicine (Hematology\/Oncology), University of Alabama at Birmingham","place":["Birmingham, AL, United 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