{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:26:59Z","timestamp":1785767219012,"version":"3.56.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Albumin\/Neutrophil-to-Lymphocyte Ratio (ANLR) integrates inflammatory and nutritional pathways, yet its prognostic utility in colorectal cancer (CRC) remains underexplored. This study investigates the association between ANLR and progression-free survival (PFS) as well as overall survival (OS) in CRC patients, aiming to clarify its clinical significance and utility in treatment decision-making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 1,436 CRC patients who underwent surgical resection at a single institution between 2015 and 2017. Survival curves for PFS and OS were generated using the Kaplan-Meier method, with differences compared via log-rank tests. Cox proportional hazards regression models were used to evaluate the relationship between ANLR and survival outcomes, while logistic regression analysis assessed the independent association of ANLR with sarcopenia and postoperative complications. Nomograms incorporating ANLR and other significant prognostic factors were constructed to predict 1-, 3-, and 5-year survival rates. The clinical utility of these models was validated using decision curve analysis (DCA) against traditional TNM staging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow-up duration was 65 months (interquartile range: 41\u201378 months). Patients with low ANLR (&amp;lt;15.51) had significantly poorer 5-year PFS (48.2% vs. 63.0%, p &amp;lt; 0.001) and OS (50.9% vs. 65.8%, p &amp;lt; 0.001) compared to those with high ANLR (\u226515.51). ANLR demonstrated superior predictive efficacy for outcomes compared to other inflammation-nutrition indices. Multivariate Cox regression identified high ANLR as an independent predictor of improved PFS (hazard ratio [HR] = 0.745, 95% CI: 0.630\u20130.880, p = 0.001) and OS (HR\u00a0=\u00a00.739, 95% CI: 0.622\u20130.878, p = 0.001). Additionally, high ANLR was independently associated with a 40.7% lower risk of sarcopenia (Odds Ratio [OR] = 0.593, 95% CI: 0.442\u20130.796, p &amp;lt; 0.001) and a reduced risk of complications (OR\u00a0=\u00a00.564, 95% CI: 0.429\u20130.742, p &amp;lt; 0.001). The ANLR-based nomograms showed high predictive accuracy (C-indices: 0.719 for PFS, 0.727 for OS) and outperformed TNM staging, confirming greater clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ANLR is a promising prognostic biomarker for predicting PFS and OS in CRC patients, with additional value in assessing sarcopenia and complication risks. ANLR-based nomograms provide a valuable tool for personalized survival prediction, supporting tailored treatment strategies to improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1668103","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:35:00Z","timestamp":1774506900000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The prognostic value of the albumin\/neutrophil-to-lymphocyte ratio in colorectal cancer patients: a retrospective cohort study"],"prefix":"10.3389","volume":"16","author":[{"given":"Hailun","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]},{"name":"Guangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishuang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Gan","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]},{"name":"Department of Colorectal and Anal Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/s0140-6736(24)00360-x","article-title":"Colorectal cancer","volume":"404","author":"Eng","year":"2024","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 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