{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:40:37Z","timestamp":1777887637036,"version":"3.51.4"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the clinical significance of regulatory dual-channel digestive tract reconstruction with a pylorus-preserving approach in advanced gastric cancer through a multicenter study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 137 gastric cancer patients who underwent radical gastrectomy at three hospitals in Mianyang, China, between March 2018 and March 2023 were included. Patients were divided into a study group (n=68) undergoing regulatory dual-channel reconstruction with pylorus preservation and a control group (n=69) receiving total gastrectomy with Roux-en-Y reconstruction. Operative time, intraoperative blood loss, postoperative complications, and quality of life were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant differences were found between the groups regarding demographic and clinical characteristics, operative time, intraoperative blood loss, gastrointestinal function recovery, or hospital stay (P&amp;gt;0.05). Postoperative complications, including pulmonary infections, anastomotic leakage, gastrointestinal bleeding, and reflux esophagitis, also showed no significant differences (P&amp;gt;0.05). However, dumping syndrome was significantly less frequent in the study group (P&amp;lt;0.05). Both groups showed improvement in functional status and overall health from 1 to 24 months postoperatively. The study group had significantly higher physical function scores at 24 months (P&amp;lt;0.05), along with better emotional function and overall health scores from 6 to 24 months (P&amp;lt;0.05). Additionally, diarrhea scores were significantly lower in the study group at 1 and 6 months (P&amp;lt;0.05), while other functional and symptom domains showed no differences (P&amp;gt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Regulatory dual-channel digestive tract reconstruction with pylorus preservation is a safe and effective approach that improves postoperative quality of life in patients with advanced gastric cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Synopsis<\/jats:title>\n                    <jats:p>Pylorus-preserving dual-channel reconstruction in advanced gastric cancer improves quality of life, reduces dumping syndrome, and shows comparable safety to total gastrectomy with Roux-en-Y.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1673727","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:19:34Z","timestamp":1777609174000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multicenter clinical application of regulatory dual-channel digestive tract reconstruction with pylorus-preserving approach in advanced gastric cancer"],"prefix":"10.3389","volume":"16","author":[{"given":"Hangyu","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of General Surgery, Mianyang 404 Hospital","place":["Mianyang, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranmiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Mianyang 404 Hospital","place":["Mianyang, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Mianyang 404 Hospital","place":["Mianyang, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ming","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Mianyang 404 Hospital","place":["Mianyang, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Mianyang 404 Hospital","place":["Mianyang, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guomin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Mianyang 404 Hospital","place":["Mianyang, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaiwu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Mianyang 404 Hospital","place":["Mianyang, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s40880-017-0209-4","article-title":"Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China: a hospital-based, multicenter, cross-sectional survey","volume":"36","author":"Huang","year":"2017","journal-title":"Chin J Cancer"},{"key":"B3","article-title":"Relationship between self-perceived burden, social support and quality of life in patients with radical gastrectomy","volume":"53","author":"Han","year":"2019","journal-title":"J Harbin Med Univ"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-320234","article-title":"Is gastric cancer becoming a rare disease? A global assessment of predicted incidence trends to 2035","volume":"69","author":"Arnold","year":"2020","journal-title":"Gut"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0315-y","article-title":"A difficulty in improving population survival outcome of gastric cancer in mainland China: low proportion of early diseases","volume":"31","author":"Chen","year":"2014","journal-title":"Med Oncol (Northwood London England)"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/coc.0b013e318287bb48","article-title":"Surgical treatment of advanced gastric cancer","volume":"21","author":"Wei","year":"2018","journal-title":"Chin J Gastrointestinal Surg"},{"key":"B7","article-title":"Joint evaluation of EORTC QLQ-C30 and QLQ-STO22 on quality of life in patients with gastric cancer 3 years after subtotal gastrectomy","author":"Zhou","year":"2012","journal-title":"Int J Chin Digestion"},{"key":"B8","article-title":"Evaluation of Chinese version of Quality of Life measurement Scale EORTC QLQ-C30 for Cancer patients","author":"Wan","year":"2005","journal-title":"J Pract Oncol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-014-2473-9","article-title":"Roux-en-Y limb motility after total gastrectomy","volume":"18","author":"Herbella","year":"2014","journal-title":"J Gastrointestinal Surg"},{"key":"B10","article-title":"Application of uncut Roux-en-Y anastomosis after radical gastrectomy","volume":"27","author":"Shen","year":"2017","journal-title":"Chin J Modern Med"},{"key":"B11","article-title":"Research progress of vitamin D after digestive tract reconstruction","volume":"38","author":"Luo","year":"2015","journal-title":"J Luzhou Med Coll"},{"key":"B12","article-title":"Effect of modified double-channel jejunal interplacement gastrectomy on reconstruction of digestive tract after total gastrectomy","volume":"57","author":"Tao","year":"2017","journal-title":"Shandong Med"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1673727\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:19:34Z","timestamp":1777609174000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1673727\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":12,"alternative-id":["10.3389\/fonc.2026.1673727"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1673727","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"article-number":"1673727"}}