{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:46:42Z","timestamp":1776746802076,"version":"3.51.2"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Malignant teratomas are rare germ cell tumors characterized by undifferentiated embryonic components, exhibiting invasive and metastatic potential. While teratomas commonly arise in the gonads, such as the ovaries and testes, as well as midline locations like the sacrococcygeal region and mediastinum, the occurrence of a malignant teratoma in the femur (right femur) is exceedingly rare, with limited research available. We report the case of a 19-year-old female presented with a subcutaneous mass in the right posterior thigh for 2 months, which was later confirmed as immature teratoma (CK5\/6\n                    <jats:sup>+<\/jats:sup>\n                    , CK8\/18\n                    <jats:sup>+<\/jats:sup>\n                    , CK7\n                    <jats:sup>+<\/jats:sup>\n                    , CK20\n                    <jats:sup>+<\/jats:sup>\n                    , villin\n                    <jats:sup>+<\/jats:sup>\n                    , S-100\n                    <jats:sup>+<\/jats:sup>\n                    , Syn\n                    <jats:sup>+<\/jats:sup>\n                    , GFAP\n                    <jats:sup>+<\/jats:sup>\n                    , NF\n                    <jats:sup>+<\/jats:sup>\n                    , Neu-N\n                    <jats:sup>+<\/jats:sup>\n                    , CgA\n                    <jats:sup>+<\/jats:sup>\n                    , CD99\n                    <jats:sup>+<\/jats:sup>\n                    , Dasmin\n                    <jats:sup>-<\/jats:sup>\n                    , SMA\n                    <jats:sup>-<\/jats:sup>\n                    ) with higher expression of Ki-67. Two key like pathogenic germline variants were revealed through whole exome sequencing: BLM c.2634C&amp;gt;A (p. Tyr878 *) and MSH6 c.3986C&amp;gt;A (p. Ser1329 *). This report provides information on the clinical course of rare malignant teratoma in the right posterior thigh, including treatment strategy and prognosis.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1673801","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:22:48Z","timestamp":1776745368000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Rare malignant teratoma in the right posterior thigh"],"prefix":"10.3389","volume":"16","author":[{"given":"Yanhui","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, Qingdao Special Servicemen Recuperation Center of PLA Navy","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medicine, Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College, Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaoqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2011.01553.x","article-title":"Soft tissue metastasis of an immature teratoma of the ovary","volume":"37","author":"Byun","year":"2011","journal-title":"J Obstet Gynaecol Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-025-04075-8","article-title":"A rare case of epibulbar teratoma in an infant","author":"Rathore","year":"2025","journal-title":"Eye (Lond)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/wdev.219","article-title":"Teratoma: from spontaneous tumors to the pluripotency\/malignancy assay","volume":"5","author":"Bulic-Jakus","year":"2016","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17183041","article-title":"Immature teratoma of the ovary-A narrative review","author":"Marino","year":"2025","journal-title":"Cancers (Basel) 17"},{"key":"B5","article-title":"Testicular teratoma","volume-title":"StatPearls","author":"Farci","year":"2025"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20501","article-title":"Syndrome-causing mutations of the BLM gene in persons in the Bloom\u2019s Syndrome Registry","volume":"28","author":"German","year":"2007","journal-title":"Hum Mutat"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.18632\/aging.206291","article-title":"An overview of RecQ helicases and related diseases","volume":"17","author":"Yiu","year":"2025","journal-title":"Aging (Albany NY)"},{"key":"B8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13053-025-00322-x","article-title":"Genomic characterization of patients with colorectal cancer","volume":"23","author":"Mahdouani","year":"2025","journal-title":"Hered Cancer Clin Pract"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32440-6","article-title":"Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"390","author":"Coleman","year":"2017","journal-title":"Lancet"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1673801\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:22:55Z","timestamp":1776745375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1673801\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":9,"alternative-id":["10.3389\/fonc.2026.1673801"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1673801","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"article-number":"1673801"}}