{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:00:38Z","timestamp":1785128438621,"version":"3.55.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Older men demonstrate heightened susceptibility to both diffuse large B-cell lymphoma (DLBCL) and lung adenocarcinoma. Nevertheless, synchronous presentation of DLBCL and adenocarcinoma within the same lymph node remains exceptionally rare. A 70-year-old Chinese man presented with a 1-year history of a productive cough with white sputum, progressive shortness of breath, and chest tightness. The patient received four cycles of R-CHOP immunochemotherapy directed at the DLBCL. Cervical lymphadenopathy decreased markedly after treatment, and no obvious lymphoma progression was documented during the 5-month follow-up. No specific treatment was administered for the lung adenocarcinoma. This unusual coexistence of DLBCL and metastatic carcinoma poses a significant diagnostic challenge, underscoring the critical need for precise early histopathological evaluation to guide optimal therapeutic intervention.<\/jats:p>","DOI":"10.3389\/fonc.2026.1679895","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T04:26:07Z","timestamp":1785126367000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Coexistence of diffuse large B-cell lymphoma and lung adenocarcinoma in one lymph node: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Huichao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, The Fourth Hospital of Hebei Medical University","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Fourth Hospital of Hebei Medical University","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Fourth Hospital of Hebei Medical University","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Lund University","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguang","family":"Ji","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Lund University","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Fourth Hospital of Hebei Medical University","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shang","sequence":"additional","affiliation":[{"name":"Oncology Hematology Department, University-Town Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Fourth Hospital of Hebei Medical University","place":["Shijiazhuang, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics, 2013","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/s12672-025-01958-w","article-title":"Diffuse large B cell lymphoma (DLBCL): epidemiology, pathophysiology, risk stratification, advancement in diagnostic approaches and prospects: narrative review","volume":"16","author":"Berhan","year":"2025","journal-title":"Discov Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.012211","article-title":"World cancer report 2014","volume":"7","author":"McGuire","year":"2016","journal-title":"Adv Nutr"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.258.7.921","article-title":"Age trends of lung cancer stage at diagnosis. 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