{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:03:55Z","timestamp":1779685435081,"version":"3.53.1"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Despite significant advances in oncologic therapeutics, chemoradiotherapy-induced complications, including chemotherapy-induced peripheral neuropathy (CIPN) and hip dysfunction, remain clinically challenging to manage with pharmacological interventions alone. This report presents the case of a 52-year-old male with a history of right-sided lung cancer resection performed more than three years previously and confirmed bone metastasis for over two years. Following metastasis to the right ilium and acetabulum, the patient developed pain, numbness, gait disturbance, and impaired mobility in the right lower extremity. The symptoms deteriorated following local radiotherapy. Marked symptomatic improvement was observed following three courses of acupuncture treatment. At baseline, the patient was diagnosed with Grade III CIPN, with a lower extremity pain Visual Analog Scale (VAS) score of 7.8 and a Harris Hip Score (HHS) of 35. After treatment, CIPN severity improved to Grade I, the VAS score decreased to 3, and the HHS increased to 80. The patient\u2019s Physical Component Summary (PCS) score increased from 28.6 to 72.3, and the Mental Component Summary (MCS) score improved from 34.2 to 78.8. No adverse events were reported throughout the treatment period. The patient reported high satisfaction with treatment outcomes and ceased all analgesic medications. The patient continues to receive maintenance acupuncture to sustain therapeutic benefits and mitigate long-term chemoradiotherapy-related sequelae.<\/jats:p>","DOI":"10.3389\/fonc.2026.1684346","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:44:08Z","timestamp":1779684248000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acupuncture for post-chemoradiotherapy complications in lung cancer with bone metastasis: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Kaihua","family":"Song","sequence":"first","affiliation":[{"name":"The First Clinical Medical College, Zhejiang Chinese Medical University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Shen","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Zhejiang Chinese Medical University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiazhen","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Zhejiang Chinese Medical University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxin","family":"Jiang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Zhejiang Chinese Medical University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhai","family":"Hong","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"B1","unstructured":"WHO Report on Cancer: Setting Priorities, Investing Wisely and Providing Care for All"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111450","article-title":"The metastasizing mechanisms of lung cancer: Recent advances and therapeutic challenges","volume":"138","author":"Xie","year":"2021","journal-title":"BioMed Pharmacother"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0142(19971015)80:8+<1588::aid-cncr9>3.3.co;2-z","article-title":"Skeletal complications of Malignancy","volume":"80","author":"Coleman","year":"1997","journal-title":"Cancer"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-007-0051-0","article-title":"Predictors of survival in patients with bone metastasis of lung cancer","volume":"466","author":"Sugiura","year":"2008","journal-title":"Clin Orthop."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0304-3959(96)03267-8","article-title":"Malignant bone pain: pathophysiology and treatment","volume":"69","author":"Mercadante","year":"1997","journal-title":"Pain"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0931","article-title":"Clinical features of metastatic bone disease and risk of skeletal morbidity","volume":"12","author":"Re","year":"2006","journal-title":"Clin Cancer Res Off. J Am Assoc Cancer Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109126","article-title":"FMNL1 down-regulation suppresses bone metastasis through reducing TGF-\u03b21 expression in non-small cell lung cancer (NSCLC)","volume":"117","author":"Yang","year":"2019","journal-title":"BioMed Pharmacother"},{"key":"B8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s10585-018-9951-5","article-title":"Sema4D expression and secretion are increased by HIF-1\u03b1 and inhibit osteogenesis in bone metastases of lung cancer","volume":"36","author":"Chen","year":"2019","journal-title":"Clin Exp Metastasis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"977","DOI":"10.6004\/jnccn.2019.0038","article-title":"Adult cancer pain, version 3.2019, NCCN clinical practice guidelines in oncology","volume":"17","author":"Swarm","year":"2019","journal-title":"J Natl Compr Canc. Netw"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00076-3","article-title":"Assessment of cancer pain: a prospective evaluation in 2266 cancer patients referred to a pain service","volume":"64","author":"Grond","year":"1996","journal-title":"Pain"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2741\/2945","article-title":"Neurotoxic effects of antineoplastic drugs: the lesson of pre-clinical studies","volume":"13","author":"Cavaletti","year":"2008","journal-title":"Front Biosci J Virtual. Libr."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.04.007","article-title":"Nutraceuticals and chemotherapy induced peripheral neuropathy (CIPN): a systematic review","volume":"32","author":"Schloss","year":"2013","journal-title":"Clin Nutr"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2019.05.013","article-title":"Effect of exercise on taxane chemotherapy\u2013induced peripheral neuropathy in women with breast cancer: a randomized controlled trial","volume":"19","author":"Bland","year":"2019","journal-title":"Clin Breast Cancer"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20122904","article-title":"Chemokine signaling in chemotherapy-induced neuropathic pain","volume":"20","author":"Brandolini","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/toxics3020152","article-title":"Taxane-induced peripheral neurotoxicity","volume":"3","author":"Velasco","year":"2015","journal-title":"Toxics"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170915143217","article-title":"Prevention and treatment for chemotherapy-induced peripheral neuropathy: therapies based on CIPN mechanisms","volume":"17","author":"Ly","year":"2019","journal-title":"Curr Neuropharmacol."},{"key":"B17","article-title":"Treatment of chemotherapy-induced peripheral neuropathy: systematic review and recommendations","volume":"21","author":"Hou","year":"2018","journal-title":"Pain Physician."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(62)90502-0","article-title":"Pathologic central dislocation of the hip secondary to metastatic neoplasm","volume":"103","author":"Smith","year":"1962","journal-title":"Am J Surg"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2018.04.003","article-title":"Home care with acupuncture increased the quality of life in a patient with advanced cancer with neuropathic pain induced by bone metastasis: a case report","volume":"16","author":"Su","year":"2018","journal-title":"J Integr Med"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0489","article-title":"Acupuncture for chemotherapy\u2010induced peripheral neuropathy in breast cancer survivors: a randomized controlled pilot trial","volume":"25","author":"Lu","year":"2020","journal-title":"Oncologist"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2021.101372","article-title":"A feasibility trial of acupuncture in cancer patients undergoing radiotherapy treatment","volume":"43","author":"Hughes","year":"2021","journal-title":"Complement. Ther Clin Pract"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154430","article-title":"Acupuncture for cancer-related conditions: An overview of systematic reviews","volume":"106","author":"Zhang","year":"2022","journal-title":"Phytomed. Int J Phytother Phytopharm."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1136\/aim.22.3.122","article-title":"A cumulative review of the range and incidence of significant adverse events associated with acupuncture","volume":"22","author":"White","year":"2004","journal-title":"Acupunct. Med J Br Med Acupunct. Soc"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.08.003","article-title":"The CARE guidelines: consensus-based clinical case report guideline development","volume":"67","author":"Gagnier","year":"2014","journal-title":"J Clin Epidemiol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.08.016","article-title":"Studies comparing numerical rating scales, verbal rating scales, and visual analogue scales for assessment of pain intensity in adults: a systematic literature review","volume":"41","author":"Hjermstad","year":"2011","journal-title":"J Pain Symptom. Manage."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20549","article-title":"Measures of hip function and symptoms: Harris hip score (HHS), hip disability and osteoarthritis outcome score (HOOS), Oxford hip score (OHS), Lequesne index of severity for osteoarthritis of the hip (LISOH), and American Academy of Orthopedic Surgeons (AAOS) hip and knee questionnaire","volume":"63","author":"Nilsdotter","year":"2011","journal-title":"Arthritis Care Res"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1177\/2050312116671725","article-title":"SF-36 total score as a single measure of health-related quality of life: scoping review","volume":"4","author":"Lins","year":"2016","journal-title":"SAGE Open Med"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16457","article-title":"Repurposing chemotherapy-induced peripheral neuropathy grading","volume":"31","author":"Velasco","year":"2024","journal-title":"Eur J Neurol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1177\/09645284231197235","article-title":"Evaluation of the analgesic effect of acupuncture in advanced pancreatic cancer: a case report","volume":"41","author":"Liu","year":"2023","journal-title":"Acupunct. Med"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2022.101599","article-title":"A case report of immediate effects of acupuncture on neuropathic cancer breakthrough pain","volume":"48","author":"Huemer","year":"2022","journal-title":"Complement. Ther Clin Pract"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1177\/0964528420957016","article-title":"Effect of acupuncture in the treatment of lymphangioma: a case report","volume":"39","author":"Huang","year":"2021","journal-title":"Acupunct. Med"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1163990","article-title":"Enhanced acupuncture therapy for radiotherapy-related neuropathic pain in patients with gynecologic cancer: a report of two cases and brief review","volume":"14","author":"Dan-feng","year":"2023","journal-title":"Front Neurol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/920807","article-title":"Acupuncture treatment for bortezomib-induced peripheral neuropathy: a case report","volume":"2011","author":"Bao","year":"2011","journal-title":"Pain Res Treat"},{"key":"B34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1136\/aim.24.2.87","article-title":"Acupuncture treatment for chemotherapy-induced peripheral neuropathy \u2013 a case series","volume":"24","author":"Wong","year":"2006","journal-title":"Acupunct. Med"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1136\/aim.25.3.109","article-title":"Acupuncture, ketamine and piriformis syndrome \u2013 a case report from palliative care","volume":"25","author":"Spiller","year":"2007","journal-title":"Acupunct. Med"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3736\/jintegrmed2013055","article-title":"Integrative techniques using acupuncture, Chinese herbal medicine, diet, and supplements for polycystic ovary syndrome: a case report","volume":"11","author":"Ehling","year":"2013","journal-title":"J Integr Med"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-5900(03)00556-X","article-title":"Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review","volume":"4","author":"McNicol","year":"2003","journal-title":"J Pain"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/bjaed\/mkv044","article-title":"Chemotherapy-induced peripheral neuropathic pain","volume":"16","author":"Gupta","year":"2016","journal-title":"BJA. Educ"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.470849","article-title":"Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth","volume":"111","author":"Kirchmair","year":"2005","journal-title":"Circulation"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01632.x","article-title":"Acupuncture treatment improves nerve conduction in peripheral neuropathy","volume":"14","author":"Schr\u00f6der","year":"2007","journal-title":"Eur J Neurol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1097\/ALN.0000000000000101","article-title":"Mechanisms of acupuncture-electroacupuncture on persistent pain","volume":"120","author":"Zhang","year":"2014","journal-title":"Anesthesiology"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.05.004","article-title":"Neural mechanism underlying acupuncture analgesia","volume":"85","author":"Zhao","year":"2008","journal-title":"Prog Neurobiol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1177\/1534735418788667","article-title":"Acupuncture for bortezomib-induced peripheral neuropathy: not just for pain","volume":"17","author":"Zhi","year":"2018","journal-title":"Integr Cancer Ther"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934084","article-title":"Electroacupuncture enhances antioxidative signal pathway and attenuates neuropathic pain induced by chemotherapeutic paclitaxel","volume":"68","author":"Zhao","year":"2019","journal-title":"Physiol Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.4449\/aib.v149i2.1365","article-title":"Electroacupucture and nerve growth factor: potential clinical applications","volume":"149","author":"Manni","year":"2011","journal-title":"Arch Ital. Biol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-002-8262-9","article-title":"Changed skin blood perfusion in the fingertip following acupuncture needle introduction as evaluated by laser Doppler perfusion imaging","volume":"17","author":"Litscher","year":"2002","journal-title":"Lasers. Med Sci"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/516916","article-title":"A systematic review of experimental and clinical acupuncture in chemotherapy-induced peripheral neuropathy","volume":"2013","author":"Franconi","year":"2013","journal-title":"Evid-Based. Complement. Altern Med ECAM."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e26270","article-title":"Comprehensive landscape-style investigation of the molecular mechanism of acupuncture at ST36 single acupoint on different systemic diseases","volume":"10","author":"Fan","year":"2024","journal-title":"Heliyon"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X0500317X","article-title":"Acupuncture stimulation for motor cortex activities: a 3T fMRI study","volume":"33","author":"Jeun","year":"2005","journal-title":"Am J Chin Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1158\/2326-6066.CIR-23-0309","article-title":"Combination of anti-PD-1 and electroacupuncture induces a potent antitumor immune response in microsatellite-stable colorectal cancer","volume":"12","author":"Wang","year":"2024","journal-title":"Cancer Immunol Res"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119259","article-title":"Electroacupuncture regulates inflammatory cytokines by activating the vagus nerve to enhance antitumor immunity in mice with breast tumors","volume":"272","author":"Zhang","year":"2021","journal-title":"Life Sci"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"B53","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1097\/gscm.0000000000000011","article-title":"Effect of internal heat-type acupuncture on bone remodeling in a glucocorticoid-induced osteoporosis model rabbit by regulating the triplet of OPG-RANKL-RANK","volume":"1","author":"Tian","year":"2023","journal-title":"Guidel. Stand. Chin Med"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.714244","article-title":"PAC1 receptor mediates electroacupuncture-induced neuro and immune protection during cisplatin chemotherapy","volume":"12","author":"Li","year":"2021","journal-title":"Front Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1177\/15347354241302072","article-title":"Systematic review and meta-analysis of acupuncture for modulation of immune and inflammatory markers in cancer patients","volume":"23","author":"Liu","year":"2024","journal-title":"Integr Cancer Ther"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-024-4119-4","article-title":"Effectiveness of acupuncture in improving quality of life for patients with advanced cancer: A systematic review and meta-analysis","volume":"31","author":"Xin","year":"2025","journal-title":"Chin J Integr Med"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1684346\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:44:24Z","timestamp":1779684264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1684346\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":56,"alternative-id":["10.3389\/fonc.2026.1684346"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1684346","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"article-number":"1684346"}}