{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:43:51Z","timestamp":1775108631638,"version":"3.50.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) is an indolent B-cell lymphoma for which current imaging modalities offer limited diagnostic value. This article reports a comparison of the imaging features of\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG and\n                    <jats:sup>68<\/jats:sup>\n                    Ga-pentixafor in this disease and reviews the relevant literature. A 60-year-old woman presented with a 6-month history of fever and scattered systemic lymphadenopathy. The patient underwent both\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG and\n                    <jats:sup>68<\/jats:sup>\n                    Ga-pentixafor PET\/CT imaging within a 2-day period.\n                    <jats:sup>68<\/jats:sup>\n                    Ga-pentixafor PET\/CT identified significantly increased metabolic activity in enlarged lymph nodes, the spleen, and bone marrow. Immunohistochemical staining demonstrated a phenotypic profile positive for CD5, CD20, and CD23; showed focal positivity for cyclin D1; and was negative for CD10, BCL-6, and SOX11, findings consistent with the diagnosis of CLL\/SLL. Compared with\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG,\n                    <jats:sup>68<\/jats:sup>\n                    Ga-pentixafor PET\/CT detected more lesions with significantly higher tracer uptake. This case suggests that, for patients with CLL\/SLL,\n                    <jats:sup>68<\/jats:sup>\n                    Ga-pentixafor PET\/CT demonstrates significantly superior performance in evaluating the tumor burden and delineating the disease extent compared with\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG PET\/CT.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1699568","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T04:18:30Z","timestamp":1775103510000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["68Ga-pentixafor PET\/CT shows better diagnostic performance than 18F-FDG PET\/CT in chronic lymphocytic leukemia\/small lymphocytic lymphoma: a case report and review of literature"],"prefix":"10.3389","volume":"16","author":[{"given":"Detao","family":"Wu","sequence":"first","affiliation":[{"name":"School of Clinical Medical, North China University of Science and Technology","place":["Tangshan, China"]},{"name":"Department of Nuclear Medicine, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranliang","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Emergency, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]},{"name":"Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]},{"name":"Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]},{"name":"Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congna","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]},{"name":"Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]},{"name":"Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]},{"name":"Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhu","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hebei General Hospital","place":["Shijiazhuang, Hebei, China"]},{"name":"Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015142088","article-title":"Imaging for staging and response assessment in lymphoma","volume":"276","author":"Johnson","year":"2015","journal-title":"Radiology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41435-024-00258-7","article-title":"CXCR4 overexpression in chronic lymphocytic leukemia associates with poorer prognosis: A prospective, single-center, observational study","volume":"25","author":"Xue","year":"2024","journal-title":"Genes Immun"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2021.04.003","article-title":"The pattern of use of PET\/CT scans in the clinical management of chronic lymphocytic 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