{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:40:22Z","timestamp":1773916822129,"version":"3.50.1"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aims to systematically map the intellectual landscape and emerging trends in lipid metabolism research within hepatocellular carcinoma from 2014 to 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 607 peer-reviewed publications were retrieved from the Web of Science Core Collection and PubMed. Bibliometric and visualization tools, including VOSviewer and CiteSpace, were employed to perform data analysis, including keyword co-occurrence and cluster analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified a significant surge in research activity, with 53.05% of the total literature published in the last three years. China and the USA emerged as the leading contributors, with the University of California System and the journal Cancers being the most prolific institution and publication outlet, respectively. Current research hotspots are centered on the mechanisms by which oxidative stress drives the transformation of non-alcoholic fatty liver disease into hepatocellular carcinoma. Furthermore, three critical frontiers for future investigation were identified: (1) the regulatory role of PPAR\u03b3 in lipid metabolic reprogramming and its therapeutic implications; (2) the molecular mechanisms of the farnesoid X receptor in modulating bile acid metabolism during hepatocarcinogenesis; and (3) the NF-\u03baB signaling pathways that mediate metabolic shifts and confer chemoresistance in liver cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings provide a comprehensive reference for prioritizing research directions and therapeutic target discovery in the metabolic-related oncology domain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1704007","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:23:46Z","timestamp":1773897826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Recent trends in lipid metabolism research in liver cancer: a bibliometric analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Yaru","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University","place":["Changsha, China"]},{"name":"School of Traditional Chinese Medicine, Hunan University of Chinese Medicine","place":["Changsha, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Hunan University of Chinese Medicine","place":["Changsha, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfeng","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Hunan University of Chinese Medicine","place":["Changsha, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Hunan University of Chinese Medicine","place":["Changsha, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Hunan University of Chinese Medicine","place":["Changsha, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhong","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Hunan University of Chinese Medicine","place":["Changsha, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University","place":["Changsha, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2024.102406","article-title":"Evolving global etiology of hepatocellular carcinoma (HCC): insights and trends for 2024","volume":"15","author":"Koshy","year":"2025","journal-title":"J Clin Exp Hepatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116722","article-title":"Aggregation-induced emission: Application in diagnosis and therapy of hepatocellular carcinoma","volume":"266","author":"Xu","year":"2024","journal-title":"Biosens Bioelectron"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2455539","article-title":"Risk factors for hepatocellular carcinoma: an umbrella review of systematic review and meta-analysis","volume":"57","author":"Wang","year":"2025","journal-title":"Ann Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2025.189345","article-title":"Nervous system in hepatocellular carcinoma: Correlation, mechanisms, therapeutic implications, and future perspectives","volume":"1880","author":"Li","year":"2025","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B5","article-title":"Minimally invasive liver surgery for primary and secondary liver Malignancies","volume":"108","author":"Talukder","year":"2025","journal-title":"R I Med J (2013)"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1242\/dmm.048934","article-title":"Metabolic reprogramming in cancer: mechanistic insights from Drosophila","volume":"14","author":"Wong","year":"2021","journal-title":"Dis Model Mech"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.123022","article-title":"Targeting lipid metabolism via nanomedicine: A prospective strategy for cancer therapy","volume":"317","author":"Huang","year":"2025","journal-title":"Biomaterials"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2025.189318","article-title":"Comprehensive insights of etiological drivers of hepatocellular carcinoma: Fostering targeted nano delivery to anti-cancer regimes","volume":"1880","author":"Ghosh","year":"2025","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.05.017","article-title":"Cellular fatty acid metabolism and cancer","volume":"18","author":"Currie","year":"2013","journal-title":"Cell Metab"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000492","article-title":"Evolutionary patterns and research frontiers in neoadjuvant immunotherapy: a bibliometric analysis","volume":"109","author":"Jiang","year":"2023","journal-title":"Int J Surg"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-025-04052-w","article-title":"Lipogenesis and MASLD: re-thinking the role of SREBPs","volume":"99","author":"Nakagawa","year":"2025","journal-title":"Arch Toxicol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"72","DOI":"10.21037\/cco-25-83","article-title":"A bibliometric analysis of 2000\u20132024 on interventional therapy for liver cancer and tumor immune microenvironment","volume":"14","author":"Liang","year":"2025","journal-title":"Chin Clin Oncol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1474869","article-title":"Global research trends in the tumor microenvironment of hepatocellular carcinoma: Insights based on bibliometric analysis","volume":"15","author":"Han","year":"2024","journal-title":"Front Immunol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1689280","article-title":"Research trends on the quality of life in patients with metabolic dysfunction-associated fatty liver diseases: A scientific metrology study","volume":"12","author":"Huang","year":"2025","journal-title":"Front Nutr"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S551949","article-title":"Global trends and research hotspots in social isolation among cancer patients: A bibliometric analysis, (2005-2024)","volume":"18","author":"Lu","year":"2025","journal-title":"J Multidiscip Healthc"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-2025-1211","article-title":"Research hotspots and frontiers in the tumor microenvironment of gastric cancer: A bibliometric review from 2005 to 2024","volume":"14","author":"Zhang","year":"2025","journal-title":"Transl Cancer Res"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01042-6","article-title":"The lancet commission on addressing the global hepatocellular carcinoma burden: Comprehensive strategies from prevention to treatment","volume":"406","author":"Chan","year":"2025","journal-title":"Lancet"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.joi.2017.08.007","article-title":"bibliometrix: An R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J Informetrics"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3145\/epi.2022.sep.02","article-title":"SCImago Graphica: a new tool for exploring and visually communicating data","volume":"31","author":"Hassan-Montero","year":"2022","journal-title":"Profesional la informaci\u00f3n"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307513100","article-title":"Searching for intellectual turning points: progressive knowledge domain visualization","author":"Chen","year":"2004","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1048211","article-title":"Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study","volume":"13","author":"Wu","year":"2022","journal-title":"Front Pharmacol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s13018-022-03068-7","article-title":"Knowledge structure and emerging trends on osteonecrosis of the femoral head: a bibliometric and visualized study","volume":"17","author":"Wu","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i42.5781","article-title":"Research status and hotspots of autoimmune gastritis: A bibliometric analysis","volume":"29","author":"Yu","year":"2023","journal-title":"World J Gastroenterol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000004075","article-title":"Artificial intelligence in patient education: A bibliometric analysis","author":"Guo","year":"2025","journal-title":"Int J Surg"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204265","article-title":"Human fatty liver disease: old questions and new insights","volume":"332","author":"Cohen","year":"2011","journal-title":"Science"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.08.025","article-title":"The interaction of hepatic lipid and glucose metabolism in liver diseases","volume":"56","author":"Bechmann","year":"2012","journal-title":"J Hepatol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00381-6","article-title":"Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention","volume":"18","author":"Huang","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nature16969","article-title":"NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis","volume":"531","author":"Ma","year":"2016","journal-title":"Nature"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14709","article-title":"Non-alcoholic fatty liver disease: a review of epidemiology, risk factors, diagnosis and management","volume":"50","author":"Huang","year":"2020","journal-title":"Intern Med J"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2020.99506","article-title":"Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis - epidemiology, risk factors, clinical implications and treatment","volume":"6","author":"Stra\u015b","year":"2020","journal-title":"Clin Exp Hepatol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.244780","article-title":"Oxidative stress: the lowest common denominator of multiple diseases","volume":"14","author":"Matschke","year":"2019","journal-title":"Neural Regener Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"498","DOI":"10.2174\/1568009616666160926124043","article-title":"Role of oxidative stress in hepatitis C virus induced hepatocellular carcinoma","volume":"17","author":"Fu","year":"2017","journal-title":"Curr Cancer Drug Targets"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.08.012","article-title":"Epidemiology and risk-stratification of NAFLD-associated HCC","volume":"75","author":"Ioannou","year":"2021","journal-title":"J Hepatol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2020.11.001","article-title":"NAFLD-related HCC","volume":"149","author":"Banini","year":"2021","journal-title":"Adv Cancer Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00762","article-title":"Recent insights into the multiple pathways driving non-alcoholic steatohepatitis-derived hepatocellular carcinoma","volume":"9","author":"Takakura","year":"2019","journal-title":"Front Oncol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.607011","article-title":"Oxidation-specific epitopes in non-alcoholic fatty liver disease","volume":"11","author":"Hendrikx","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-021-01385-5","article-title":"PPAR\u03b3 and diabetes: beyond the genome and towards personalized medicine","volume":"21","author":"Cataldi","year":"2021","journal-title":"Curr Diabetes Rep"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00102","article-title":"The role of peroxisome proliferator-activated receptor gamma (PPARG) in adipogenesis: applying knowledge from the fish aquaculture industry to biomedical research","volume":"8","author":"Wafer","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2005.03.003","article-title":"PPARs: therapeutic targets for metabolic disease","volume":"26","author":"Berger","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2536828100","article-title":"Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle","volume":"100","author":"He","year":"2003","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100223","article-title":"ZBTB20 regulates WNT\/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis","volume":"3","author":"To","year":"2021","journal-title":"JHEP Rep"},{"key":"B48","doi-asserted-by":"publisher","first-page":"4594","DOI":"10.1038\/s41467-022-32283-3","article-title":"A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma","volume":"13","author":"Lu","year":"2022","journal-title":"Nat Commun"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113414","article-title":"IGFALS suppresses hepatocellular carcinoma progression by stabilizing PPAR-\u03b3","volume":"143","author":"Xu","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1038\/s41467-022-29846-9","article-title":"USP22 regulates lipidome accumulation by stabilizing PPAR\u03b3 in hepatocellular carcinoma","volume":"13","author":"Ning","year":"2022","journal-title":"Nat Commun"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i3.385","article-title":"Hepatocellular carcinoma with obstructive jaundice: diagnosis, treatment and prognosis","volume":"9","author":"Qin","year":"2003","journal-title":"World J Gastroenterol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(00)00051-4","article-title":"A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis","volume":"6","author":"Goodwin","year":"2000","journal-title":"Mol Cell"},{"key":"B53","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.1038\/s41467-025-58809-z","article-title":"Disrupting bile acid metabolism by suppressing Fxr causes hepatocellular carcinoma induced by YAP activation","volume":"16","author":"Liu","year":"2025","journal-title":"Nat Commun"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.010","article-title":"Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis","volume":"76","author":"Liu","year":"2022","journal-title":"J Hepatol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.060","article-title":"Hippo pathway activity influences liver cell fate","volume":"157","author":"Yimlamai","year":"2014","journal-title":"Cell"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.2174\/138161210790883787","article-title":"Hepatocellular carcinoma and non-alcoholic fatty liver disease: from a clinical to a molecular association","volume":"16","author":"Petta","year":"2010","journal-title":"Curr Pharm Des"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.17669","article-title":"Amentoflavone enhances the anti-tumor activity of regorafenib by promoting apoptosis and inhibiting NF-\u03baB-mediated metastasis in hepatocellular carcinoma","volume":"45","author":"Lin","year":"2025","journal-title":"Anticancer Res"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.183","article-title":"NF-\u03baB and STAT3 - key players in liver inflammation and cancer","volume":"21","author":"He","year":"2011","journal-title":"Cell Res"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2025.102936","article-title":"Enhanced hepatoprotective efficacy of quercetin nanoparticles versus free quercetin against acrylamide-induced hepatotoxicity through modulation of MAPK\/NF-\u03baB\/NLRP3 signaling pathways and molecular docking validation","volume":"95","author":"Atta","year":"2025","journal-title":"Tissue Cell"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e004297","DOI":"10.1136\/jitc-2021-004297","article-title":"Bufalin stimulates antitumor immune response by driving tumor-infiltrating macrophage toward M1 phenotype in hepatocellular carcinoma","volume":"10","author":"Yu","year":"2022","journal-title":"J Immunother Cancer"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01062-1","article-title":"Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-\u03baB p65-activated SLC7A11 transcription","volume":"44","author":"Wang","year":"2023","journal-title":"Acta Pharmacol Sin"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1704007\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:23:47Z","timestamp":1773897827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1704007\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":61,"alternative-id":["10.3389\/fonc.2026.1704007"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1704007","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"article-number":"1704007"}}