{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:49:01Z","timestamp":1777265341486,"version":"3.51.4"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>T-cell lymphoblastic lymphoma (T-LBL) is a highly aggressive malignancy that originates from immature precursor T lymphocytes and is characterized by rapid progression. The typical clinical manifestations of T-LBL include superior vena cava syndrome and respiratory compression symptoms such as cough and dyspnea caused by large anterior mediastinal masses. Primary pituitary T-LBL is exceptionally rare, with only seven cases reported worldwide (including the case described in this study).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>This article presents the case of an elderly female patient who presented with headaches and progressive visual deterioration. Brain MRI revealed a sellar\/suprasellar mass, while whole-body PET\/CT imaging revealed a tumor confined to the central nervous system. Laboratory tests for blood parameters and pituitary hormone levels were normal. Following neuroendoscopic tumor resection, pathological examination and immunohistochemical analysis confirmed a diagnosis of pituitary T-LBL coexisting with pituitary adenoma. The patient\u2019s headaches and visual impairment were resolved postoperatively. Subsequent chemotherapy with high-dose methotrexate (HD-MTX), temozolomide, and liposomal doxorubicin effectively controlled the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case highlights the rarity of concurrent sellar lymphoma and pituitary adenoma and summarizes previously reported cases of primary pituitary T-LBL to provide clinical diagnostic and therapeutic insights into this rare disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1704451","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:28:30Z","timestamp":1777264110000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pituitary T-lymphoblastic lymphoma combined with pituitary adenoma: a rare case 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