{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:04:35Z","timestamp":1780985075501,"version":"3.54.1"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"\n Objective<\/jats:title>\n To evaluate current evidence on the safety and impact on ovarian reserve of single-port laparoscopic cystectomy (SLC) for the treatment of benign ovarian cysts.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We comprehensively searched PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov from their inception to 31 December 2025. We included randomized controlled trials (RCTs) or non-randomized studies (NRSs) comparing SLC with conventional laparoscopic cystectomy (CLC) for benign ovarian cysts. The primary outcomes were postoperative changes in serum anti-M\u00fcllerian hormone (AMH) concentration, intraoperative complications, postoperative complications, and cosmetic outcomes. All analyses were performed using random-effects or fixed-effects models.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In total, 14 full-text studies involving 1, 691 participants were included in the final analysis. There were no significant differences between SLC and CLC in the incidence of intraoperative complications (\n P<\/jats:italic>\n \u00a0=\u00a00.50), postoperative complications (\n P<\/jats:italic>\n \u00a0=\u00a00.49), postoperative changes in serum AMH concentration (\n P<\/jats:italic>\n \u00a0=\u00a00.06), estimated blood loss (\n P<\/jats:italic>\n \u00a0=\u00a00.99), hemoglobin loss (\n P<\/jats:italic>\n \u00a0=\u00a00.76), time to flatus (\n P<\/jats:italic>\n \u00a0=\u00a00.68), length of hospital stay (\n P<\/jats:italic>\n \u00a0=\u00a00.17), or analgesic use (\n P<\/jats:italic>\n \u00a0=\u00a00.91). SLC was associated with significantly lower postoperative pain scores at 24 hours (\n P<\/jats:italic>\n \u00a0=\u00a00.02) but longer operative time (\n P<\/jats:italic>\n \u00a0=\u00a00.001) compared with CLC.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This systematic review and meta-analysis provides evidence that SLC may be offered as a minimally invasive surgical alternative for women with benign ovarian cysts, at the cost of a longer operative time compared with CLC. Given the retrospective design of the majority of the included studies, further large-scale randomized controlled trials are warranted to validate these findings.<\/jats:p>\n <\/jats:sec>\n \n Systematic review registration<\/jats:title>\n \n https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/<\/jats:ext-link>\n , identifier CRD42024602477.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fonc.2026.1704981","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:44:40Z","timestamp":1780983880000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Single-port compared with conventional laparoscopic ovarian cystectomy for benign ovarian cysts: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Yuhao","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Heilongjiang University of Chinese Medicine","place":["Harbin, Heilongjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China","place":["Hengyang, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital","place":["Hengyang, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupei","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital","place":["Hengyang, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital","place":["Hengyang, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1097\/GRF.0000000000000086","article-title":"Role of minimally invasive surgery in the management of adnexal masses","volume":"58","author":"Sisodia","year":"2015","journal-title":"Clin Obstet Gynecol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200208000-00010","article-title":"Laparoscopic management of adnexal masses: a gold standard","volume":"14","author":"Canis","year":"2002","journal-title":"Curr Opin Obstet Gynecol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318288828c","article-title":"Single-incision laparoscopy in gynecologic surgery: a systematic review and meta-analysis","volume":"121","author":"Murji","year":"2013","journal-title":"Obstet Gynecol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1017812","article-title":"Surgical technique of endometrioma excision impacts on the ovarian reserve. 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