{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:27:53Z","timestamp":1788834473888,"version":"build-2803163510"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 23K0661300"],"award-info":[{"award-number":["JP 23K0661300"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer cachexia is a multifactorial syndrome characterized by progressive skeletal muscle wasting and impaired response to conventional nutritional support, affecting up to 80% of advanced cancer patients and contributing to poor prognosis. Excessive fatty acid oxidation and mitochondrial reactive oxygen species (ROS) generation have been implicated in cachexia-associated muscle atrophy, but the underlying mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We investigated the role of cancer cell\u2013derived exosomes in metabolic alterations of skeletal muscle cells. Exosomes from a pro-cachectic renal carcinoma cell line (RXF393) induced myotube atrophy, enhanced mitochondrial ROS production, impaired mitochondrial respiration, and reduced expression of isocitrate dehydrogenase 2 (IDH2) and respiratory chain complex subunits compared to observations in non-cachectic controls. miRNA profiling identified enrichment of miR-1260b in pro-cachectic exosomes, and transfection with a miR-1260b mimic reproduced these phenotypes, including IDH2 downregulation, impaired antioxidant defense, and mitochondrial dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings demonstrate that cancer-derived exosomal miR-1260b suppresses IDH2, disrupts mitochondrial redox balance, and promotes muscle wasting. This study reveals a mechanistic link between exosomal miRNAs and mitochondrial dysfunction in cancer cachexia and suggests that maintaining mitochondrial redox homeostasis may represent a novel therapeutic strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1715589","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:48:25Z","timestamp":1778215705000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Regulatory mechanisms of mitochondrial function by cancer-derived exosomes in cachexia"],"prefix":"10.3389","volume":"16","author":[{"given":"Ryotaro","family":"Tomida","sequence":"first","affiliation":[{"name":"Department of Urology, Institute of Biomedical Sciences, Tokushima University Graduate School","place":["Tokushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Biomedical Sciences, Tokushima University Graduate School","place":["Tokushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School","place":["Tokushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School","place":["Tokushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syuya","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School","place":["Tokushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School","place":["Tokushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Biomedical Sciences, Tokushima University Graduate School","place":["Tokushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nikawa","sequence":"additional","affiliation":[{"name":"Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School","place":["Tokushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Fukawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Biomedical Sciences, Tokushima University Graduate School","place":["Tokushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.s261585","article-title":"Cancer cachexia: definition, staging, and emerging treatments","volume":"12","author":"Ni","year":"2020","journal-title":"Cancer Manag Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00752-w","article-title":"Understanding the molecular basis of anorexia and tissue wasting in cancer cachexia","volume":"54","author":"Yeom","year":"2022","journal-title":"Exp Mol Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00624-w","article-title":"The interplay of immunology and cachexia in infection and cancer","volume":"22","author":"Baazim","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"17105","DOI":"10.1146\/annurev.nutr.26.061505.111151","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nrc927","article-title":"Cachexia in cancer patients","volume":"2","author":"Tisdale","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/528182a","article-title":"Cachexia. 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