{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:15:51Z","timestamp":1791288951611,"version":"4.3.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>We describe the case of a 68\u2010year\u2010old woman who presented with a 4\u2010cm ulcerated lesion in the left paraclitoral area. Imaging revealed increased FDG uptake at the vulvar lesion and multiple skeletal sites but no suspicious inguinal lymphadenopathy, while breast imaging showed a 30\u2010mm BI\u2010RADS 5 lesion in the upper outer quadrant of the left breast. Core biopsies confirmed two distinct primaries: an invasive ductal carcinoma of the breast and an eccrine ductal\u2010type adenocarcinoma of the vulva arising from anogenital mammary\u2010like glands. A bone biopsy demonstrated metastatic breast carcinoma. The patient underwent radical anterior vulvectomy with bilateral sentinel lymph node biopsy; final pathology confirmed a well\u2010differentiated, adenocarcinoma of mammary\u2010gland type of the vulva (pT1bN0) with negative margins. Because of breast metastases, systemic therapy with ribociclib and letrozole was initiated but later discontinued owing to therapy\u2010related acute myeloid leukemia. At 9\u2010month follow\u2010up, no recurrence of the vulvar disease was observed. This report highlights one of the very few documented instances of synchronous mammary\u2010like vulvar carcinoma and breast carcinoma. It underscores the diagnostic complexity of the case and emphasizes the importance of an individualized, multidisciplinary approach tailored to tumor biology, staging, and patient comorbidities.<\/jats:p>","DOI":"10.3389\/fonc.2026.1716250","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:28:27Z","timestamp":1768886907000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["A case report of a mammary gland type adenocarcinoma of the vulva in a patient with a concomitant breast cancer: a diagnostic challenge"],"prefix":"10.3389","volume":"16","author":[{"given":"Ilenia","family":"Nobile","sequence":"first","affiliation":[{"name":"Department of Public Health, School of Medicine, University of Naples \u201cFederico II\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Tessitore","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine, University of Naples \u201cFederico II\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine, University of Naples \u201cFederico II\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominga","family":"Boccia","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine, University of Naples \u201cFederico II\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Mignogna","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, School of Medicine, University of Naples \u201cFederico II\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bifulco","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine, University of Naples \u201cFederico II\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Della Corte","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples \u201cFederico II\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19881115)62:10<2234::AID-CNCR2820621027>3.0.CO;2-F","article-title":"Adenocarcinoma arising in vulvar breast tissue","volume":"62","author":"Simon","year":"1988","journal-title":"Cancer"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/19.084","article-title":"Primary breast carcinoma of the vulva metastatic to lymph nodes and bones: a case report and literature review","volume":"24","author":"Ananthula","year":"2020","journal-title":"Perm J"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000001160","article-title":"Ectopic primary ductal breast carcinoma of the vulva: a case report and literature review","volume":"85","author":"Mansour","year":"2023","journal-title":"Ann\u00a0Med Surg (Lond)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.32074\/1591-951X-848","article-title":"Mammary-like adenocarcinoma of the vulva: a rare case report with next generation sequencing","volume":"115","author":"Lobrano","year":"2023","journal-title":"Pathologica"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197612)38:6<2570::AID-CNCR2820380650>3.0.CO;2-T","article-title":"Carcinoma of supernumerary breast of vulva with bilateral mammary cancer","volume":"38","author":"Guerry","year":"1976","journal-title":"Cancer"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00237.x","article-title":"A rare association of synchronous intraductal carcinoma of the breast and invasive carcinoma of ectopic breast tissue of the vulva: case report and literature review","author":"Intra","year":"2006","journal-title":"Int J Gynecol Cancer"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2024.1611376","article-title":"Case report: Primary vulvar adenocarcinoma of mammary gland type \u2013 its genetic characteristics by focused next-generation sequencing","volume":"30","author":"Hu","year":"2024","journal-title":"Pathol Oncol Res"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2024.1611803","article-title":"Modified clock mapping biopsy sec. 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