{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T06:09:52Z","timestamp":1772431792003,"version":"3.50.1"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>This report describes a clinically rare case of early-stage primary extranodal marginal zone B-cell lymphoma of the prostate. A 73-year-old male presented with urinary hesitancy. Physical examination revealed mild prostatic enlargement. Prostate biopsy, immunohistochemistry, and genetic testing strongly suggested mucosa-associated lymphoid tissue (MALT) lymphoma. Bone marrow aspiration indicated no bone marrow involvement. Positron Emission Tomography-Computed Tomography (PET-CT) and Emission Computed Tomography (ECT) scans showed no evidence of involvement in other sites. Ultimately, the patient was definitively diagnosed with primary prostatic MALT lymphoma, Ann Arbor stage IE. He underwent external beam radiation therapy to the prostate, receiving a total dose of 3000 cGy delivered in 15 fractions. During radiotherapy, the patient experienced no significant adverse reactions. Following treatment, urinary obstruction symptoms markedly improved. Follow-up abdominal and urinary tract ultrasound examinations at 1week, 1month, and 4months post-radiotherapy showed marked tumor regression with no signs of recurrence. This report aims to share the treatment experience of this case, hoping to provide insights for clinicians.<\/jats:p>","DOI":"10.3389\/fonc.2026.1721390","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T05:21:31Z","timestamp":1772428891000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary extranodal marginal zone non-hodgkin lymphoma of the prostate: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiaoru","family":"Gao","sequence":"first","affiliation":[{"name":"The First Clinical Medicine College of Gansu University of Traditional Chinese Medicine","place":["Lanzhou, China"]},{"name":"Department of Radiotherapy I, Gansu Provincial People\u2019s Hospital","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinru","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Clinical Medicine College of Gansu University of Traditional Chinese Medicine","place":["Lanzhou, China"]},{"name":"Department of Radiotherapy II, Gansu Provincial People\u2019s Hospital","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangfei","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Clinical Medicine College of Gansu University of Traditional Chinese Medicine","place":["Lanzhou, China"]},{"name":"Department of Oncologic Surgery, Gansu Provincial People\u2019s Hospital","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy I, Gansu Provincial People\u2019s Hospital","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67330-0","article-title":"Primary lymphoma of the prostate: good outcome with doxorubicin-based combination chemotherapy","volume":"153","author":"Sarris","year":"1995","journal-title":"J Urol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980815)83:4<732::AID-CNCR15>3.0.CO;2-T","article-title":"Malignant lymphoma involving the prostate: report of 62 cases","volume":"83","author":"Bostwick","year":"1998","journal-title":"Cancer"},{"key":"B3","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1186\/s13256-021-03143-3","article-title":"Primary diffuse large B-cell lymphoma of the prostate: a case report and review of the literature","volume":"15","author":"Ren","year":"2021","journal-title":"J Med Case Rep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"rjad598","DOI":"10.1093\/jscr\/rjad598","article-title":"Primary prostate lymphoma: a rare presentation of lower urinary tract symptoms in young aged patient","volume":"2024","author":"Alhamadani","year":"2024","journal-title":"J Surg Case Rep"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2017.02.005","article-title":"How gene polymorphisms can influence clinical response and toxicity following R-CHOP therapy in patients with diffuse large B cell lymphoma","volume":"31","author":"Falduto","year":"2017","journal-title":"Blood Rev"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)53297-8","article-title":"Urological presentations of nonHodgkin\u2019s lymphomas","volume":"128","author":"Whitmore","year":"1982","journal-title":"J Urol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i7.1627","article-title":"Prostate lymphoma with renal obstruction; reflections on diagnosis and treatment: Two case reports","volume":"11","author":"Chen","year":"2023","journal-title":"World J Clin cases"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1553415","article-title":"Primary prostatic Burkitt\u2019s lymphoma complicated with hemophagocytic lymphohistiocytosis: a case report and literature review","volume":"15","author":"Guo","year":"2025","journal-title":"Front Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1721390\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T05:21:31Z","timestamp":1772428891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1721390\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":8,"alternative-id":["10.3389\/fonc.2026.1721390"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1721390","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]},"article-number":"1721390"}}