{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:07:56Z","timestamp":1773194876503,"version":"3.50.1"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This report assesses the feasibility of a sequential treatment strategy for a patient with active tuberculosis (TB) complicated by thrombocytosis and squamous cell lung carcinoma, involving initial anti-TB therapy combined with aspirin, followed by anticancer treatment. It highlights the challenge of balancing infection control, hematologic stability, and oncologic management in this complex scenario.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 55-year-old man with a 15-day history of cough, sputum, and fever was found to have markedly elevated platelet levels. Bronchoscopy confirmed active TB with concurrent lung cancer. Following anti-TB therapy combined with aspirin for antiplatelet management, platelet counts returned to normal. One month later, antitumor chemotherapy with nab-paclitaxel and carboplatin was initiated, leading to effective disease control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Active TB complicated by thrombocytosis and squamous cell lung carcinoma poses diagnostic and therapeutic challenges. This case demonstrates that early anti-TB therapy combined with aspirin can effectively normalize platelet counts and facilitate the timely initiation of anticancer treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1723876","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:29:24Z","timestamp":1773120564000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Management challenges of active tuberculosis complicated by thrombocytosis and squamous cell lung carcinoma"],"prefix":"10.3389","volume":"16","author":[{"given":"Chen","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Yantai Yuhuangding Hospital","place":["Shandong, Yantai, 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