{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:49:38Z","timestamp":1776235778344,"version":"3.50.1"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Ovarian carcinosarcoma (OCS) is an uncommon and highly aggressive subtype of ovarian carcinoma characterized by the simultaneous occurrence of two malignant components: carcinomatous and sarcomatous. Located at the fimbrial region of the fallopian tube, serous tubal intraepithelial carcinoma (STIC) represents a form of precursor lesion for high-grade serous carcinoma (HGSC). In the current report, we present an intriguing case study of left OCS concomitant with ipsilateral STIC. Immunohistochemical (IHC) assessment showed a similar staining pattern of the carcinomatous OCS component and STIC. In conclusion, the development of OCS from STIC should be considered. Such a situation represents both a rare phenomenon and a challenge for preoperative diagnostic protocol. A careful application of selected IHC markers, p53 and Ki-67 in particular, may substantially help not only in the differential diagnosis but also in clinicopathological algorithms based on OCS molecular profiling into HGSC-like and non-HGSC-like variants.<\/jats:p>","DOI":"10.3389\/fonc.2026.1727634","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:46:56Z","timestamp":1776232016000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The development of ovarian carcinosarcoma from serous tubal intraepithelial carcinoma: an immunohistochemical case report with literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Paula","family":"Szlendak","sequence":"first","affiliation":[{"name":"IIDepartment of Gynecological Surgery and Gynecological Oncology, Lublin Medical University","place":["Lublin, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Lewkowicz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lublin Medical University","place":["Lublin, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Maastricht University Medical Centre (MUMC)","place":["Maastricht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Semczuk","sequence":"additional","affiliation":[{"name":"IIDepartment of Gynecological Surgery and Gynecological Oncology, Lublin Medical University","place":["Lublin, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"J\u00f3\u017awik","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecologic Oncology, Medical University of Bia\u0142ystok","place":["Bia\u0142ystok, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Semczuk","sequence":"additional","affiliation":[{"name":"IIDepartment of Gynecological Surgery and Gynecological Oncology, Lublin Medical University","place":["Lublin, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.12.418","article-title":"Carcinosarcoma of the ovary: a review of the literature","volume":"125","author":"del Carmen","year":"2012","journal-title":"Gynecol Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.critrevonc.2018.12.006","article-title":"Ovarian carcinosarcoma: current developments and future perspectives","volume":"134","author":"Boussios","year":"2019","journal-title":"Crit Rev Oncol Hematol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.06.003","article-title":"Carcinosarcoma of the ovary, fallopian tube, and peritoneum. 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