{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:02:30Z","timestamp":1788498150617,"version":"build-2803163510"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Anaplastic lymphoma kinase (ALK)-rearranged renal cell carcinoma (ALK-RCC) is an extremely rare subtype of RCC, accounting for less than 1% of all cases. Its computed tomography (CT) features remain poorly characterized, hindering preoperative diagnosis. We report the case of a 34-year-old female who presented with painless gross hematuria. Abdominal ultrasound revealed a well-circumscribed, hyperechoic heterogeneous mass in the upper pole of the right kidney. Contrast-enhanced CT demonstrated a solitary, medullary-based hypodense mass with multiple punctate and patchy calcifications and mild heterogeneous enhancement. The patient underwent laparoscopic nephron-sparing surgery with complete resection. Histopathology showed papillary architecture with ISUP\/WHO grade 2 atypical cells. Immunohistochemistry was diffusely positive for ALK (clone D5F3). Fluorescence in situ hybridization confirmed ALK rearrangement, and next-generation sequencing identified a novel DCTN1::ALK fusion\u2014the first report of such a fusion in ALK-RCC. Follow-up showed no evidence of recurrence. This case highlights distinctive CT features of ALK-RCC that may raise suspicion in young patients and guide molecular testing. The identification of the\n                    <jats:italic>DCTN1::ALK<\/jats:italic>\n                    fusion expands the molecular landscape of ALK-RCC and supports the potential utility of ALK inhibitors.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1732867","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:29:21Z","timestamp":1773120561000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: imaging features of anaplastic lymphoma kinase-rearranged renal cell carcinoma with a novel DCTN1::ALK fusion"],"prefix":"10.3389","volume":"16","author":[{"given":"Fei","family":"Sang","sequence":"first","affiliation":[{"name":"Department of Radiology, Peking University Shenzhen Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Peking University Shenzhen Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.06.016","article-title":"The 2022 world health organization classification of tumours of the urinary system and male genital organs\u2014Part A: renal, penile, and testicular tumours","volume":"82","author":"Moch","year":"2022","journal-title":"Eur Urol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0578-0","article-title":"Alk rearranged renal cell carcinoma (Alk-rcc): A multi-institutional study of twelve cases with identification of novel partner genes clip1, kif5b and 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