{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:51:18Z","timestamp":1782449478807,"version":"3.54.5"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pituitary tumor-transforming 1 (PTTG1) plays a crucial role in cancer pathogenesis and has been associated with survival outcomes and clinicopathological features in patients with various tumors. Therefore, we conducted a comprehensive meta-analysis to evaluate the prognostic and clinicopathological significance of PTTG1 expression in solid tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search of the PubMed, EMBASE and Web of Science was performed to identify eligible studies until July 20, 2025. The hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Stata SE 12.0 software was used to perform the meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>22 studies from 21 articles were included in this meta-analysis. The pooled results showed that patients with high PTTG1 expression had poorer overall survival (OS)(HR:1.85,95%CI:1.55-2.20) and disease-free survival\/recurrence-free survival (DFS\/RFS) (HR:3.48, 95%CI:1.81-6.70). Subgroup analysis showed that high PTTG1 expression was mainly associated with worse OS in renal cell carcinoma(RCC),non-small cell lung cancer(NSCLC),breast cancer(BC), esophageal squamous cell carcinoma(ESCC) and laryngeal cancer(LRGC). Furthermore, high PTTG1 expression was significantly associated with tumor stage (III-IV vs I-II), T stage (T3\u20134 vs T1-2), lymphatic invasion(Yes vs No) and metastasis (Yes vs No).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PTTG1 may serve as a prognostic indicator in specific cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1734781","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:35:34Z","timestamp":1782448534000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and prognostic implications of pituitary tumor-transforming gene 1 in solid tumors"],"prefix":"10.3389","volume":"16","author":[{"given":"Peng","family":"Dong","sequence":"first","affiliation":[{"name":"Department of General Surgery, the Second Hospital & Clinical Medical School, Lanzhou University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Shenzhen Bao \u2018an District People\u2019s Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhui","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Shenzhen Bao \u2018an District People\u2019s Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Shenzhen Bao \u2018an District People\u2019s Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanqiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Shenzhen Bao \u2018an District People\u2019s Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Shenzhen Bao \u2018an District People\u2019s Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Shenzhen Bao \u2018an District People\u2019s Hospital","place":["Shenzhen, Guangdong, 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