{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:23:44Z","timestamp":1790288624472,"version":"4.1.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fanconi syndrome (FS) is a rare renal complication of monoclonal gammopathies including multiple myeloma (MM), typically diagnosed before or at the time of MM presentation. Onset and progression of FS during anti-myeloma treatment are extremely rare and easily misdiagnosed, resulting in delayed electrolyte correction and clinical deterioration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report a 55-year-old woman with \u03ba light chain MM who developed FS during induction therapy and experienced recurrence after autologous stem cell transplantation (ASCT). Initial workup showed subclinical tubular dysfunction with renal glycosuria and elevated tubular markers, which was initially overlooked. Shortly after induction therapy, she developed severe and recurrent hypokalemia and hypophosphatemia accompanied by progressive gastrointestinal symptoms despite hematological remission. A multidisciplinary consultation confirmed MM-associated FS. Electrolyte replacement, particularly phosphate supplementation, rapidly relieved her symptoms. With ongoing anti-myeloma therapy, glycosuria gradually resolved. Following ASCT, FS recurred but resolved with supportive care. The patient has remained in remission during continued follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anti-myeloma therapy may transiently induce or exacerbate FS, especially in patients with pre-existing renal tubular dysfunction, likely due to synergistic tubular toxicity of anti-myeloma agents. Early recognition, frequent electrolyte monitoring and prompt correction, as well as multidisciplinary collaboration, are crucial for optimal management of FS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1735528","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T05:36:51Z","timestamp":1773207411000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Fanconi syndrome developing and worsening during anti-myeloma therapy in multiple myeloma: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Pengpeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology, Second Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou First People\u2019s Hospital","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Second Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou First People\u2019s Hospital","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Hematology, Second Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou First People\u2019s Hospital","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Second Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou First People\u2019s Hospital","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinguang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e239","DOI":"10.1038\/bcj.2014.55","article-title":"Clinical features and treatment outcome in newly diagnosed Chinese patients with multiple myeloma: results of a multicenter analysis","volume":"4","author":"Lu","year":"2014","journal-title":"Blood Cancer J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e23057","DOI":"10.1002\/jcla.23057","article-title":"Effect factors related to a high probability of hemodialysis independence in newly diagnosed multiple myeloma patients requiring hemodialysis","volume":"34","author":"Song","year":"2020","journal-title":"J Clin Lab Anal"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-016-0232-3","article-title":"Light chain Fanconi syndrome in a patient with acute myeloid leukemia and monoclonal gammopathy of undetermined significance","volume":"5","author":"Daniel","year":"2016","journal-title":"CEN Case Rep"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90601-4","article-title":"Fanconi syndrome in adults. 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