{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:05:37Z","timestamp":1780031137536,"version":"3.53.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Superficial hypopharyngeal carcinoma typically presents with no obvious clinical manifestations but poses significant management challenges due to its unique anatomical location and potential aggressiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy and safety of endoscopic submucosal dissection (ESD) in the treatment of superficial hypopharyngeal carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed the clinical data of 11 patients with 13 superficial hypopharyngeal carcinomas who underwent ESD at the Gastrointestinal Endoscopy Center of Jiangsu Provincial Hospital of Traditional Chinese Medicine from November 2022 to November 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All 11 patients were male, with 13 lesions located as follows: left pyriform fossa (53.8%), right pyriform fossa (23.1%), posterior hypopharyngeal wall (15.4%), and posterior cricoid region (7.7%). The average lesion diameter was 1.79\u00a0cm (range: 0.1\u20133.9 cm). The procedure took an average of 34 minutes (range: 10\u201390 minutes). Intraoperatively, subcutaneous cervicothoracic emphysema occurred in 1 patient (7.7%). Postoperatively, 5 patients (38.5%) reported postoperative pain, and 1 patient (7.7%) developed postoperative fever. During follow-up, choking symptoms were noted in 2 cases (18.2%), and hoarseness occurred in 4 cases (36.4%). The average length of hospitalization was 7.3 days (range: 5\u201310 days). Postoperative pathology revealed intraepithelial high-grade neoplasia in 46.2% of lesions, carcinoma\n                      <jats:italic>in situ<\/jats:italic>\n                      in 7.7%, and invasive carcinoma in 46.2%. One case of squamous cell carcinoma had positive vertical margins, requiring additional radiotherapy and chemotherapy, while the remaining lesions had negative peripheral and basal margins. The mean follow-up period was 17 months (range: 9\u201325 months), with no recurrence, metastasis, or esophageal inlet stenosis observed in any patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ESD is a safe and effective treatment for superficial hypopharyngeal carcinoma and can be considered a viable option for the minimally invasive treatment of this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1738370","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:54:07Z","timestamp":1780030447000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the effectiveness of endoscopic submucosal dissection for hypopharyngeal lesions- a comprehensive evaluation"],"prefix":"10.3389","volume":"16","author":[{"given":"Changen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Central Hospital, Tianjin University \/Tianjin Third Central Hospital, Tianjin Institute of Geriatrics, Tianjin Third Central Hospital Branch","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Center, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine)","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohui","family":"Wang","sequence":"additional","affiliation":[{"name":"Pathology Department, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine)","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingsheng","family":"Ling","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Center, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine)","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1398063","article-title":"Global epidemiology and socioeconomic correlates of hypopharyngeal cancer in 2020 and its projection to 2040: findings from GLOBOCAN 2020","volume":"14","author":"Mousavi","year":"2024","journal-title":"Front Oncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4539","article-title":"Trends in the incidence of head and neck cancer by subsite between 1993 and 2015 in Japan","volume":"11","author":"Kawakita","year":"2022","journal-title":"Cancer Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29186","article-title":"Predicting factors for oncological and functional outcome in hypopharyngeal cancer","volume":"131","author":"Visini","year":"2021","journal-title":"Laryngoscope"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk179","article-title":"Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium","volume":"99","author":"Hashibe","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-017-1135-9","article-title":"Current status of superficial pharyngeal squamous cell carcinoma in Japan","volume":"22","author":"Rikitake","year":"2017","journal-title":"Int J Clin Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.01.049","article-title":"Endoscopic submucosal dissection for treatment of early stage hypopharyngeal carcinoma","volume":"64","author":"Shimizu","year":"2006","journal-title":"Gastrointest Endosc"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-024-10747-5","article-title":"Efficacy of endoscopic surveillance for pharyngeal mucosa during endoscopic resection for pharyngeal carcinoma: a multicenter prospective study","volume":"38","author":"Kimura","year":"2024","journal-title":"Surg Endosc"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/den.13544","article-title":"Endoscopic submucosal dissection for superficial hypopharyngeal cancer with thin endoscope","volume":"32","author":"Muramoto","year":"2020","journal-title":"Dig Endosc"},{"key":"B9","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1186\/s12885-017-3685-7","article-title":"A modified endoscopic submucosal dissection for a superficial hypopharyngeal cancer: a case report and technical discussion","volume":"17","author":"Di","year":"2017","journal-title":"BMC Cancer"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-025-11636-1","article-title":"The safety and efficacy of endoscopic submucosal dissection for superficial pharyngeal squamous cell neoplasms: a single-center study in China","volume":"39","author":"Dai","year":"2025","journal-title":"Surg Endosc"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1159\/000528424","article-title":"Endoscopic laryngopharyngeal surgery combined with endoscopic submucosal dissection as a treatment option for superficial hypopharyngeal cancer with suspected synchronous lymph node metastasis","volume":"17","author":"Sugimoto","year":"2023","journal-title":"Case Rep Gastroenterol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23106","article-title":"Clinical outcomes of endoscopic mucosal resection and endoscopic submucosal dissection as a transoral treatment for superficial pharyngeal cancer","volume":"35","author":"Hanaoka","year":"2013","journal-title":"Head Neck"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(25)00020-8","article-title":"International consensus on laryngeal preservation strategies in laryngeal and hypopharyngeal cancer","volume":"26","author":"Ferrari","year":"2025","journal-title":"Lancet Oncol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-07225-6","article-title":"Outcomes of endoscopic submucosal dissection for treatment of superficial pharyngeal cancers: systematic review and meta-analysis","volume":"67","author":"Kamal","year":"2022","journal-title":"Dig Dis Sci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.5009\/gnl19266","article-title":"Efficacy of current traction techniques for endoscopic submucosal dissection","volume":"14","author":"Abe","year":"2020","journal-title":"Gut Liver"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.04.027","article-title":"Long-term outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer","volume":"74","author":"Muto","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1392094","article-title":"The short-term and long-term outcomes of the endoscopic resection for the superficial pharyngeal squamous cell carcinoma","volume":"3","author":"Kinjo","year":"2015","journal-title":"Endosc Int Open"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195309)6:5<963::aid-cncr2820060515>3.0.co;2-q","article-title":"Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin","volume":"6","author":"Slaughter","year":"1953","journal-title":"Cancer"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1055\/a-2284-9184","article-title":"Efficacy and safety of the water pressure method for endoscopic submucosal dissection in superficial pharyngeal cancer","volume":"12","author":"Matsuura","year":"2024","journal-title":"Endosc Int Open"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn321463-20210115-00042","article-title":"Endoscopic submucosal dissection for early hypopharyngeal carcinoma and precancerous lesions","volume":"39","author":"Gong","year":"2022","journal-title":"Chin J Dig Endosc"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/sle.0000000000001025","article-title":"Endoscopic submucosal dissection for superficial pharyngeal carcinoma is effective and safe","volume":"32","author":"Chen","year":"2021","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.07.013","article-title":"A new technique for pharyngeal endoscopic submucosal dissection: peroral countertraction (with video)","volume":"76","author":"Iizuka","year":"2012","journal-title":"Gastrointest Endosc"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1271112","article-title":"Clinical advantage of endoscopic submucosal dissection over endoscopic mucosal resection for early mesopharyngeal and hypopharyngeal cancers","volume":"43","author":"Iizuka","year":"2011","journal-title":"Endoscopy"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.01.049","article-title":"Endoscopic submucosal dissection for treatment of early stage hypopharyngeal carcinoma","volume":"64","author":"Shimizu","year":"2006","journal-title":"Gastrointest Endosc"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1738370\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:54:11Z","timestamp":1780030451000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1738370\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":24,"alternative-id":["10.3389\/fonc.2026.1738370"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1738370","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"article-number":"1738370"}}