{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:36:59Z","timestamp":1770813419677,"version":"3.50.1"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012505","name":"Hebei Medical University","doi-asserted-by":"publisher","award":["20250524, GZ20260084"],"award-info":[{"award-number":["20250524, GZ20260084"]}],"id":[{"id":"10.13039\/501100012505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Prostatic stromal sarcoma (PSS) is a rare malignant mesenchymal tumor originating from the specialized stroma of the prostate. It is a heterogeneous tumor, in which a predominantly phyllodes architecture has been documented only in isolated case reports. The co-occurrence of a phyllodes-predominant PSS and prostate adenocarcinoma (PCA) is even more exceptional. Here, we reported a case of a 52-year-old man with the chief complaint of dysuria for 2 months in 2018. Magnetic resonance imaging (MRI) revealed a mass lesion in the left lobe of the prostate. The patient underwent surgical resection, and the pathological examination revealed PSS with a phyllodes-predominant structure accompanied by PCA. We report this rare case to provide valuable clinical information for clinicians and pathologists and to improve the awareness and diagnostic level of this disease.<\/jats:p>","DOI":"10.3389\/fonc.2026.1742518","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T07:41:30Z","timestamp":1770795690000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Phyllodes-predominant prostatic stromal sarcoma concurrent with prostate adenocarcinoma: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Hongguang","family":"Lian","sequence":"first","affiliation":[{"name":"Department of Pathology, The Second Hospital, Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenfeng","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Imaging, The Second Hospital, Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Hospital, Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Tian","sequence":"additional","affiliation":[{"name":"Second Department of Oncology, The Second Hospital, Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Second Hospital, Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinfeng","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Second Hospital, Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Second Hospital, Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.155","article-title":"Mesenchymal tumors of the prostate","volume":"31","author":"McKenney","year":"2018","journal-title":"Modern Pathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4103\/IJPM.IJPM_427_18","article-title":"Rapidly progressing Malignant phyllodes tumor of the p rostate with normal prostate-specific antigen levels: A case report","volume":"63","author":"Zhang","year":"2020","journal-title":"Indian J Pathol Microbiol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.4081\/rt.2010.e57","article-title":"Prostatic stromal tumor with fatal outcome in a young man: histopathological and immunohistochemical case presentation","volume":"2","author":"Colombo","year":"2010","journal-title":"Rare Tumors"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2025.102963","article-title":"A case of stromal sarcoma of the prostate with the incidental detection of prostate adenocarcinoma","volume":"59","author":"Xu","year":"2025","journal-title":"Urol Case Rep"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjab576","article-title":"A\u2002case\u2002of\u2002incidental\u2002STUMP\u2002discovery\u2002in a patient with concurrent prostatic adenocarcinoma","volume":"2021","author":"Ladner","year":"2021","journal-title":"J Surg Case Rep"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2019.101015","article-title":"Phyllodes tumor of the prostate: Long-term follow up of a rare condition","volume":"28","author":"Razi","year":"2019","journal-title":"Urol Case Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199802000-00002","article-title":"Sarcomas and related proliferative lesions of specialized prostatic stroma: a clinicopathologic study of 22 cases","volume":"22","author":"Gaudin","year":"1998","journal-title":"Am J Sur Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.07.002","article-title":"The 2022 world health Organization Classification of Tumors of the Urinary System and Male Genital Organs-Part B: Prostate and Urinary Tract Tumors","volume":"82","author":"Netto","year":"2022","journal-title":"Eur Urol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00818-6","article-title":"Re-evaluating tumors of purported specialized prostatic stromal origin reveals molecular heterogeneity, including non-recurring gene fusions characteristic of uterine and soft tissue sarcoma subtypes","volume":"34","author":"Acosta","year":"2021","journal-title":"Mod Pathol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60121918","article-title":"Primary prostatic stromal sarcoma: A case report and review of the literature","volume":"60","author":"Erul","year":"2024","journal-title":"Med (Kaunas)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000005389","article-title":"Primary prostatic stromal sarcoma on 18 F-PSMA PET\/CT","volume":"49","author":"Chen","year":"2024","journal-title":"Clin Nucl Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2004.08.002","article-title":"The role of the stromal microenvironment in prostate cancer","volume":"15","author":"Condon","year":"2005","journal-title":"Semin Cancer Biol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2004.10.017","article-title":"Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development","volume":"92","author":"Cunha","year":"2004","journal-title":"J Steroid Biochem Mol Biol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.gde.2007.12.006","article-title":"Microenvironmental regulation of cancer development","volume":"18","author":"Hu","year":"2008","journal-title":"Curr Opin Genet Dev"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198612253152606","article-title":"Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing","volume":"315","author":"Dvorak","year":"1986","journal-title":"N Engl J Med"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1477","article-title":"Friends or foes-bipolar effects of the tumour stroma in cancer","volume":"4","author":"Mueller","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1593\/neo.10776","article-title":"Stromal activation associated with development of prostate cancer in prostate-targeted fibroblast growth factor 8b transgenic mice","volume":"12","author":"Elo","year":"2010","journal-title":"Neoplasia"},{"key":"B18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4103\/cytojournal.cytojournal_46_16","article-title":"Metastatic prostatic stromal sarcoma: A challenging diagnosis on fine-needle aspiration with broad differential diagnosis","volume":"14","author":"Khurram","year":"2017","journal-title":"Cytojournal"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4321\/s0004-06142005000900012","article-title":"Prostatic stromal sarcoma in a 20-year-old patient","volume":"58","author":"Lara","year":"2005","journal-title":"Arch Esp Urol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1742518\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T07:41:31Z","timestamp":1770795691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1742518\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":19,"alternative-id":["10.3389\/fonc.2026.1742518"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1742518","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]},"article-number":"1742518"}}