{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T05:14:16Z","timestamp":1783314856925,"version":"3.54.6"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Collision tumors harbor two distinct histological features at the same site, and sellar collision tumors of pituitary adenoma (PA) and craniopharyngioma (CP) are extremely rare. This report presents a 64-year-old female with fatigue, anorexia, palpitations, dizziness, and exertional dyspnea. Examinations confirmed pan-hypopituitarism and life-threatening electrolyte disturbances. Preoperative MRI showed a homogeneous lesion indistinguishable from a standard macroadenoma. She underwent neuroendoscopic transsphenoidal resection. Intraoperatively, the tumor exhibited a fibrous, tough consistency with no discernible boundary between components, resulting in a \u201cblind\u201d resection of the collision pathology. Significant cavernous sinus hemorrhage (800 mL) occurred due to severe adhesion. Postoperatively, hormone replacement therapy was administered, with stable recovery and discharge on day 18. Pathology confirmed a collision of Null-cell adenoma and Adamantinomatous CP. This case highlights the diagnostic pitfall of \u201coccult\u201d collision tumors where imaging and surgical texture fail to differentiate components, necessitating comprehensive immunohistochemistry. Few similar cases have been reported, mostly involving non-functional PA and adamantinomatous CP with diverse pathogenesis hypotheses. This case supplements critical clinical data on diagnosis, surgical management, and prognosis of this rare sellar tumor, highlighting therapeutic considerations for neurosurgery clinicians.<\/jats:p>","DOI":"10.3389\/fonc.2026.1742957","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T04:20:24Z","timestamp":1783311624000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Sellar collision tumor consisting of pituitary adenoma and craniopharyngioma, with literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Junhao","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Zhongda Hospital, Southeast University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongda Hospital, Southeast University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongda Hospital, Southeast University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongda Hospital, Southeast University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhongda Hospital, Southeast University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.3.263","article-title":"Combined high grade sarcoma and serous ovarian neoplasm","volume":"45","author":"Allen","year":"1992","journal-title":"J Clin Pathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2007.00451.x","article-title":"Concurrent invasive ductal carcinoma and chronic lymphocytic leukemia manifesting as a collision tumor in breast","volume":"13","author":"Cheung","year":"2007","journal-title":"Breast J"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-2-34","article-title":"Synchronously diagnosed lymph nodal collision tumor of Malignant melanoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma: case report","volume":"2","author":"El Demellawy","year":"2007","journal-title":"Diagn Pathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.6.853","article-title":"Concurrent occurrence of gastric adenocarcinoma and duodenal neuroendocrine cell carcinoma: a composite tumour or collision tumours","volume":"48","author":"Fukui","year":"2001","journal-title":"Gut"},{"key":"B5","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/00004347-199910000-00017","article-title":"Collision of uterine rhabdoid tumor and endometrioid adenocarcinoma: a case report and review of the literature","volume":"18","author":"Gaertner","year":"1999","journal-title":"Int J Gynecol Pathol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/314158","article-title":"Gastric collision tumors: an insight into their origin and clinical significance","volume":"2015","author":"Michalinos","year":"2015","journal-title":"Gastroenterol Res Pract"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.201.3.8939227","article-title":"Collision tumors of the adrenal gland: demonstration and characterization at MR imaging","volume":"201","author":"Schwartz","year":"1996","journal-title":"Radiology"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801215)46:12<2702::aid-cncr2820461228>3.0.co;2-m","article-title":"Collision carcinoma at the esophagogastric junction: report of two cases","volume":"46","author":"Spagnolo","year":"1980","journal-title":"Cancer"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.14309\/crj.2018.39","article-title":"Pancreatic collision tumor of ductal adenocarcinoma and neuroendocrine tumor","volume":"5","author":"Wang","year":"2018","journal-title":"ACG Case Rep J"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000138184.74496.4d","article-title":"Do collision tumors of the gastroesophageal junction exist? 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