{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:00:31Z","timestamp":1771920031031,"version":"3.50.1"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007700","name":"Universitatea de Medicina si Farmacie \"Carol Davila\" Bucuresti","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background\/objectives<\/jats:title>\n                    <jats:p>Krukenberg tumors (KTs) are rare metastatic ovarian neoplasms, most frequently secondary to gastric adenocarcinomas, and typically occur in women aged 30\u201360 years. Their presentation in adolescents is exceedingly uncommon and often leads to diagnostic delays due to nonspecific symptoms and low clinical suspicion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We describe the case of an 18-year-old female presenting with progressive abdominal pain and bilateral adnexal masses. Imaging suggested advanced ovarian pathology, and surgical exploration with histopathological evaluation confirmed metastatic signet-ring cell carcinoma. Upper gastrointestinal endoscopy subsequently identified a poorly differentiated gastric adenocarcinoma, establishing the diagnosis of KT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To place this case in context, a narrative literature review was performed using PubMed, Google Scholar, and ScienceDirect. English-language case reports and case series describing KTs in patients aged \u226420 years were selected. Fifteen studies were analyzed regarding clinical presentation, histopathological features, diagnostic approach, and patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The majority of reported cases demonstrated bilateral ovarian involvement, vague abdominal symptoms, and gastric origin. Diagnostic delays were frequent, and prognosis remained poor despite multimodal treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case highlights the importance of considering metastatic gastrointestinal malignancies in the differential diagnosis of ovarian tumors in adolescents and emphasizes the value of early endoscopic assessment. By combining a rare adolescent case with a focused literature review, this work provides one of the few comprehensive syntheses of KTs in patients under 20 years, offering a unique contribution to improving clinical awareness and guiding future diagnostic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1744052","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T05:18:35Z","timestamp":1771910315000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral ovarian metastases from gastric signet-ring cell carcinoma in an 18-year-old: a case report and narrative review"],"prefix":"10.3389","volume":"16","author":[{"given":"Andreea","family":"Boiangiu","sequence":"first","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy","place":["Bucharest, Romania"]},{"name":"Elias Emergency University Hospital","place":["Bucharest, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liviu","family":"Bilteanu","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy","place":["Bucharest, Romania"]},{"name":"Faculty of Biology, University of Bucharest","place":["Bucharest, Romania"]},{"name":"Laboratory for Molecular Nanotechnologies, National Institute for Research and Development in Microtechnologies - IMT Bucharest","place":["Voluntari, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Costeschi","sequence":"additional","affiliation":[{"name":"Elias Emergency University Hospital","place":["Bucharest, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina-Andreea","family":"Nicolae","sequence":"additional","affiliation":[{"name":"Elias Emergency University Hospital","place":["Bucharest, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina-Marina","family":"Sima","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy","place":["Bucharest, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu","family":"Vladareanu","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy","place":["Bucharest, Romania"]},{"name":"Elias Emergency University Hospital","place":["Bucharest, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea-Iren","family":"Serban","sequence":"additional","affiliation":[{"name":"Faculty of Biology, University of Bucharest","place":["Bucharest, Romania"]},{"name":"Department of Preclinical Sciences, Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine","place":["Bucharest, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serban-Andrei","family":"Marinescu","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy","place":["Bucharest, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin-Nicolae","family":"Varlas","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy","place":["Bucharest, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cezar","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, The University of Texas MD Anderson Cancer Center","place":["Houston, TX, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru","family":"Filipescu","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy","place":["Bucharest, Romania"]},{"name":"Elias Emergency University Hospital","place":["Bucharest, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gmit.2013.02.006","article-title":"Identification of prognostic factors for Krukenberg tumor","volume":"2","author":"Lu","year":"2013","journal-title":"Gynecology Minimally Invasive Ther"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.5858\/2006-130-1725-AILAKT","article-title":"An in-depth look at krukenberg tumor: an overview","volume":"130","author":"Al-Agha","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.18203\/2320-1770.ijrcog20212209","article-title":"Krukenberg tumor in a young female arising from a primary adenocarcinoma of stomach: a case report","volume":"10","author":"Parmar","year":"2021","journal-title":"Int J Reprod Contracept Obstet 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