{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:57:26Z","timestamp":1772632646276,"version":"3.50.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Gastric glomus tumor (GGT) is a rare mesenchymal neoplasm of the stomach that accounts for only 1% of gastrointestinal tumors and originates from glomus cells within the gastric wall. The exact etiology remains unclear, and due to nonspecific clinical manifestations, definitive diagnosis relies on imaging, pathology, and immunohistochemistry. We report a case of a 60-year-old female with a two-year history of unexplained upper abdominal burning pain. After undergoing abdominal CT, gastroscopy, pathology, and immunohistochemistry analyses, she was diagnosed with gastric glomus tumor complicated by hepatic metastasis. The patient subsequently received chemotherapy, transcatheter arterial embolization(TAE) for hemostasis, anti-infection treatment, blood transfusion, and symptomatic and supportive care at our hospital. Ultimately, the patient\u2019s overall survival was 21 months. This article presents the case and reviews the clinical presentation, pathological features, diagnosis, and treatment strategies for GGT to provide reference for clinical practice.<\/jats:p>","DOI":"10.3389\/fonc.2026.1745685","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T07:03:56Z","timestamp":1772607836000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case Report: Gastric glomus tumor with RAD50 mutation and therapeutic advances"],"prefix":"10.3389","volume":"16","author":[{"given":"Di","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oncology, Jingzhou Hospital Affiliated to Yangtze University","place":["Jingzhou, China"]},{"name":"School of Basic Medical Sciences, Health Science Center, Yangtze University","place":["Jingzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Jingzhou Hospital Affiliated to Yangtze University","place":["Jingzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Jingzhou Hospital Affiliated to Yangtze University","place":["Jingzhou, China"]},{"name":"School of Basic Medical Sciences, Health Science Center, Yangtze University","place":["Jingzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Jingzhou Hospital Affiliated to Yangtze University","place":["Jingzhou, China"]},{"name":"School of Basic Medical Sciences, Health Science Center, Yangtze University","place":["Jingzhou, 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