{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:12:49Z","timestamp":1770963169584,"version":"3.50.1"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019413","name":"Yunnan Provincial Department of Education Science Research Fund Project","doi-asserted-by":"publisher","award":["\u7f16\u53f7\uff1a202401AY070001-042"],"award-info":[{"award-number":["\u7f16\u53f7\uff1a202401AY070001-042"]}],"id":[{"id":"10.13039\/501100019413","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>We report a rare case of large-cell neuroendocrine carcinoma (LCNEC) of the breast in a 49-year-old woman. The patient presented after discovering a right breast mass five years earlier. Mammography revealed a high-density mass and enlarged axillary lymph nodes. Biopsy confirmed invasive carcinoma with neuroendocrine differentiation. Initially, she received TE chemotherapy, followed by carboplatin and etoposide (CBP) due to disease progression. After eight cycles, she underwent modified radical mastectomy and postoperative radiotherapy. One year later, the patient developed metastases in the liver and bones, with a liver biopsy confirming recurrent LCNEC. Given the aggressive nature of the disease, trastuzumab deruxtecan (T-DXd) was initiated on October 11, 2025. Follow-up imaging demonstrated significant reduction in hepatic and peritoneal metastases, with partial response (PR) as the best observed response. Treatment with T-DXd is ongoing, highlighting its efficacy in managing aggressive LCNEC with distant metastasis.<\/jats:p>","DOI":"10.3389\/fonc.2026.1747084","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:21:59Z","timestamp":1770960119000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative recurrence and systemic metastasis of large cell neuroendocrine carcinoma of the breast: a case report including T-DXd treatment"],"prefix":"10.3389","volume":"16","author":[{"given":"Siying","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinxi","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"B1","article-title":"Solid neuroendocrine breast carcinomas: incidence, clinico-pathological features and immunohistochemical profiling","volume":"20","author":"L\u00f3pez-Bonet","year":"2008","journal-title":"Oncol Rep"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14091","article-title":"The 2019 World Health Organization classification of tumours of the breast","volume":"77","author":"Tan","year":"2020","journal-title":"Histopathology"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2003.11.008","article-title":"The prognostic influence of neuroendocrine differentiation in breast cancer: results of a long-term follow-up study","volume":"13","author":"van Krimpen","year":"2004","journal-title":"Breast"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25352","article-title":"Invasive neuroendocrine carcinoma of the breast: a distinctive subtype of aggressive mammary carcinoma","volume":"116","author":"Xiang","year":"2010","journal-title":"Cancer"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-3207-0","article-title":"Impact of histological subtype on long-term outcomes of neuroendocrine carcinoma of\u00a0the breast","volume":"148","author":"Cloyd","year":"2014","journal-title":"Breast Cancer Res Treat"},{"key":"B6","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3390\/cancers12030733","article-title":"Primary neuroendocrine neoplasms of the breast: case series and literature review","volume":"12","author":"\u00d6zdirik","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0222-z","article-title":"Primary neuroendocrine breast cancer, how\u00a0much do we know so far","volume":"29","author":"Alkaied","year":"2012","journal-title":"Med Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2011.02.006","article-title":"Effective role of hormonal therapy in metastatic primary neuroendocrine breast carcinoma","volume":"11","author":"Buttar","year":"2011","journal-title":"Clin Breast Cancer"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2012.03.007","article-title":"Small-cell cancer of the breast: what is the optimal treatment? A report and review of outcomes","volume":"12","author":"Ochoa","year":"2012","journal-title":"Clin Breast Cancer"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2013_029","article-title":"Invasive neuroendocrine carcinoma of the breast: a prognostic research of 107 Chinese patients","volume":"60","author":"Zhang","year":"2013","journal-title":"Neoplasma"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12403","article-title":"Primary large cell neuroendocrine carcinoma of the breast, a case report with an unusual clinical course","volume":"21","author":"Janosky","year":"2015","journal-title":"Breast J"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-023-07178-6","article-title":"Prognostic effect of nodal status before and after neoadjuvant chemotherapy in breast cancer: a Dutch population-based study","volume":"204","author":"de Wild","year":"2024","journal-title":"Breast Cancer Res Treat"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-016-9631-3","article-title":"Estrogen, progesterone, and HER2\/neu receptor discordance between primary and metastatic breast tumours-a review","volume":"35","author":"Yeung","year":"2016","journal-title":"Cancer Metastasis Rev"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-020-05746-8","article-title":"Estrogen, progesterone, and human epidermal growth factor receptor 2 discordance between primary and metastatic breast cancer","volume":"183","author":"Walter","year":"2020","journal-title":"Breast Cancer Res Treat"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2407086","article-title":"Trastuzumab deruxtecan after endocrine therapy in metastatic breast cancer","volume":"391","author":"Bardia","year":"2024","journal-title":"N Engl J Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJMoa2203690","article-title":"Trastuzumab deruxtecan in previously treated HER2-low advanced breast cancer","volume":"387","author":"Modi","year":"2022","journal-title":"N Engl J Med"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1747084\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:22:00Z","timestamp":1770960120000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1747084\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":16,"alternative-id":["10.3389\/fonc.2026.1747084"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1747084","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"article-number":"1747084"}}