{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:00:38Z","timestamp":1788886838049,"version":"build-2803163510"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    There are extremely few reports of concurrent multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) in the literature. To the best of our knowledge, the existence of concurrent CLL and macrofocal MM (MFMM), presenting as an extramedullary plasmacytoma (EMP) in a lymph node, has not been previously documented. Herein, we report a case of a 67-year-old male presenting with backache persisting for more than 1 month. Laboratory test results revealed a markedly elevated white blood cell count (57.0 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L) with normal platelet count and hemoglobin level. Positron emission tomography\/computed tomography scan showed high fluorodeoxyglucose uptake in the 10\n                    <jats:sup>th<\/jats:sup>\n                    thoracic vertebra (T10), T12, and the left supraclavicular lymph node. Thus, the patient underwent bone marrow aspiration, followed by T10 and left supraclavicular lymph node biopsy. Pathological analysis revealed infiltration by plasmacytoma and neoplastic B-lymphocytes. A final diagnosis of MFMM concurrent with CLL was established. The patient was subsequently treated with bortezomib, lenalidomide, and dexamethasone. After three treatment cycles, a complete response was achieved. However, treatment was discontinued due to grade 3 peripheral sensory neuropathy, and therapy was switched to daratumumab and dexamethasone. The patient remains under outpatient follow-up, with a 1-year follow-up duration.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1747723","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:22:54Z","timestamp":1769577774000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Simultaneous chronic lymphocytic leukemia and macrofocal multiple myeloma with extramedullary plasmacytoma"],"prefix":"10.3389","volume":"16","author":[{"given":"Yingming","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Ningbo No.2 Hospital","place":["Ningbo, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Ningbo Clinical Pathological Diagnosis Center","place":["Ningbo, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Ningbo No.2 Hospital","place":["Ningbo, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suying","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Ningbo No.2 Hospital","place":["Ningbo, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-806398","article-title":"iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL","volume":"131","author":"Hallek","year":"2018","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41572-024-00529-7","article-title":"Multiple myeloma","volume":"10","author":"Malard","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25755","article-title":"Real-world data on incidence, clinical characteristics and outcome of patients with macrofocal multiple myeloma (MFMM) in the era of novel therapies: A study of the Greco-Israeli collaborative myeloma working group","volume":"95","author":"Katodritou","year":"2020","journal-title":"Am J Hematol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1177\/20406207251314696","article-title":"Macrofocal multiple myeloma in the era of novel agents in China","volume":"16","author":"Dou","year":"2025","journal-title":"Ther Adv Hematol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2024.2403203","article-title":"Whole-genome sequencing reveals cellular origin of concomitant chronic lymphocytic leukemia and multiple myeloma: a case 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based on the flow cytometry immunophenotyping","volume":"104","author":"Niyonizeye","year":"2025","journal-title":"Ann Hematol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200710","article-title":"MYD88 L265P somatic mutation in Waldenstrom\u2019s macroglobulinemia","volume":"367","author":"Treon","year":"2012","journal-title":"N Engl J Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27058","article-title":"Marginal zone lymphoma: 2023 update on diagnosis and management","volume":"98","author":"Cheah","year":"2023","journal-title":"Am J Hematol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.8124","article-title":"Diagnosis and management of monoclonal gammopathy of undetermined significance: A review","volume":"185","author":"Liu","year":"2025","journal-title":"JAMA Intern Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2023.101163","article-title":"Richter\u2019s transformation: Transforming the clinical landscape","volume":"64","author":"Barrett","year":"2024","journal-title":"Blood Rev"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112138-20210908-00626","article-title":"Clinical characteristics and prognosis of 46 patients with macrofocal multiple myeloma","volume":"61","author":"Yan","year":"2022","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"B14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40644-018-0152-x","article-title":"The role of initial 18F-FDG PET\/CT in the management of patients with suspected extramedullary plasmocytoma","volume":"18","author":"Zhang","year":"2018","journal-title":"Cancer Imaging"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.6.2062.2062","article-title":"Molecular evidence for a single clonal origin in biphenotypic concomitant chronic lymphocytic leukemia and multiple myeloma","volume":"74","author":"Saltman","year":"1989","journal-title":"Blood"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.06.024","article-title":"Concurrent B-cell chronic lymphocytic leukemia and multiple myeloma treated successfully with lenalidomide","volume":"33","author":"Srinivasan","year":"2009","journal-title":"Leuk Res"}],"container-title":["Frontiers in 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