{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:02:25Z","timestamp":1780498945821,"version":"3.54.1"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the diagnosis, treatment, and prognosis of unicentric Castleman disease (UCD) located in the retroperitoneum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on the clinical data of 11 patients with pathologically confirmed retroperitoneal UCD at Peking University People\u2019s Hospital between 2010 and 2025. Data collected included gender, age, clinical manifestations, routine blood tests, tumor markers, treatment modalities, pathological characteristics, and treatment outcomes. Postoperative survival status was assessed via outpatient records and telephone follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort comprised 3 males and 8 females. One male patient had a history of long-term smoking and alcohol use, while the other 10 patients had no such history. One patient presented with lower back discomfort, one with abdominal discomfort, and the remaining 9 patients were incidentally diagnosed during health check-ups. All patients had serum inflammatory markers and tumor markers within normal ranges. Preoperative abdominal contrast-enhanced CT\/MRI localized the lesions in all cases. The mean maximum tumor diameter was 5.23 \u00b1 2.05 cm. Five patients underwent laparoscopic surgery, and six underwent open surgery. The mean operative time was 2.73 \u00b1 1.21 hours, with an intraoperative blood loss of 100 ml (IQR 20\u2013100 ml). No severe postoperative complications occurred. The mean hospital stay was 5.00 \u00b1 1.79 days, and all patients recovered well and were discharged. Pathological examination revealed the hyaline vascular type in 9 cases, the plasma cell type in 1 case, and the mixed type in 1 case. The mean follow-up duration was 68.00 \u00b1 30.41 months (range: 25\u2013112 months). By the end of follow-up, no recurrence was observed, and all patients remained alive and healthy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Retroperitoneal unicentric Castleman disease is rare and lacks specific clinical manifestations. Complete surgical resection is the optimal treatment, and patients exhibit excellent long-term prognosis upon follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1750000","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:20:03Z","timestamp":1769412003000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical diagnosis and treatment analysis of 11 cases of unicentric Castleman disease in the retroperitoneum"],"prefix":"10.3389","volume":"16","author":[{"given":"Ke","family":"Dong","sequence":"first","affiliation":[{"name":"Department of General Surgery, Jiaozhou Central Hospital","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jiaozhou Central Hospital","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Qingdao Women and Children's Hospital","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Peking University People\u2019s Hospital Qingdao Hospital","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn121090-20250101-00001","article-title":"Chinese guidelines for the diagnosis and treatment of Castleman disease (2025 edition)","volume":"46","year":"2025","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318249dcdc","article-title":"Surgery in Castleman\u2019s disease: a systematic review of 404 published cases","volume":"255","author":"Talat","year":"2012","journal-title":"Ann Surg"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003334","article-title":"International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease","volume":"4","author":"Van Rhee","year":"2020","journal-title":"Blood Adv"},{"key":"B4","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1159\/000526640","article-title":"Recent advances in castleman disease","volume":"45","author":"Hoffmann","year":"2022","journal-title":"Oncol Res Treat"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2023.10.013","article-title":"Castleman\u2019s disease, pathophysiology, advances in diagnosis and treatment","volume":"162","author":"Pertusa M\u00e1rtix","year":"2024","journal-title":"Med Clin (Barc)"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-024-01560-5","article-title":"Castleman\u2019s disease in the rheumatological practice","volume":"83","author":"Schmalzing","year":"2024","journal-title":"Z Rheumatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2011.25620","article-title":"Castleman\u2019s disease - 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