{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:05:30Z","timestamp":1771221930594,"version":"3.50.1"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Vulvar Myofibroblastoma is a rare mesenchymal tissue tumor originating from myofibroblasts, with an unclear pathogenesis and biological behavior considered to be of uncertain malignant potential or low-grade malignancy. To investigate the clinical and pathological features of vulvar myofibroblastoma, a retrospective study was conducted on a rare case of vulvar myofibroblastoma admitted to Hangzhou Obstetrics and Gynecology Hospital. The patient was an elderly woman who presented with a 3-day history of a vulvar mass. Following initial examination, she underwent vulvar mass resection. Postoperative pathology suggested a myofibroblastic tumor with biological behavior of uncertain malignant potential or low-grade malignancy. As postoperative imaging evaluation indicated residual tumor, the patient subsequently underwent wide local excision of the vulva, which confirmed the diagnosis of vulvar myofibroblastoma. Short-term follow-up showed good recovery with no signs of recurrence or metastasis. In summary, for the diagnosis of rare vulvar myofibroblastoma, imaging examinations can help determine the tumor\u2019s location, size, and relationship with surrounding tissues, but definitive diagnosis relies on histopathology. Treatment should aim for complete resection during the initial surgery. Given the uncertainty of its biological behavior, establishing a strict long-term follow-up mechanism is crucial for monitoring recurrence and ensuring the patient\u2019s long-term prognosis.<\/jats:p>","DOI":"10.3389\/fonc.2026.1750550","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T05:18:48Z","timestamp":1771219128000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Rare vulvar myofibroblastoma"],"prefix":"10.3389","volume":"16","author":[{"given":"Jiaxin","family":"Miao","sequence":"first","affiliation":[{"name":"The Fourth Clinical Medical College of Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqin","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Hangzhou Obstetrics and Gynecology Hospital","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangqian","family":"Xu","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Hangzhou Normal University","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Qian","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College of Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanying","family":"Nong","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Hangzhou Normal University","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.170","article-title":"Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma","volume":"24","author":"Flucke","year":"2011","journal-title":"Modern pathology : an Off J United States Can Acad Pathology Inc"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02063.x","article-title":"Superficial myofibroblastoma of the lower female genital tract: report of a series including tumours with a vulval location","volume":"46","author":"Ganesan","year":"2005","journal-title":"Histopathology"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0575-RA","article-title":"Inflammatory myofibroblastic tumor in female genital tract","volume":"143","author":"Shukla","year":"2019","journal-title":"Arch Pathol Lab Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2023-004364","article-title":"Inflammatory myofibroblastic tumor: a rare uterine mesenchymal neoplasm","volume":"34","author":"Goel","year":"2024","journal-title":"Int J Gynecological Cancer"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154335","article-title":"Uterine inflammatory myofibroblastic tumor","volume":"242","author":"Karpathiou","year":"2023","journal-title":"Pathol - Res Pract"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e8974","DOI":"10.1097\/MD.0000000000008974","article-title":"Uterine inflammatory myofibroblastic tumor: more common than expected: Case report and review","volume":"96","author":"Mandato","year":"2017","journal-title":"Med (Baltimore)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2022.152010","article-title":"Superficial myofibroblastoma of the lower female genital tract: A clinicopathological analysis of 15 cases","volume":"60","author":"Zhang","year":"2022","journal-title":"Ann Diagn Pathol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1750550\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T05:18:48Z","timestamp":1771219128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1750550\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,16]]},"references-count":7,"alternative-id":["10.3389\/fonc.2026.1750550"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1750550","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,16]]},"article-number":"1750550"}}