{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:36:26Z","timestamp":1776836186801,"version":"3.51.2"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    This article presents a 60-year-old woman presented with a one-year history of abdominal distension, which acutely worsened over four days prior to admission. Imaging revealed a large retroperitoneal liposarcoma. Exploratory laparotomy identified a massive tumor (approximately 45\u00d740\u00d713 cm, weighing 8\u00a0kg) invading the left kidney, adrenal gland, adnexa, left hemicolon, and mesentery. En bloc resection was performed. Postoperative pathology combined with fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization (FISH) testing demonstrated MDM2\/CDK4 amplification, confirming dedifferentiated liposarcoma (DDLPS). The patient recovered well postoperatively and was discharged following adjuvant radiotherapy (IMRT; 50 Gy in 25 fractions), chemotherapy (AD regimen), and immunotherapy (sintilimab).Through this case, we mainly understand the characteristics of the disease onset, special diagnosis, and main treatment methods.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1751424","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:36:36Z","timestamp":1776832596000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A giant dedifferentiated liposarcoma in the retroperitoneum"],"prefix":"10.3389","volume":"16","author":[{"given":"Jinglin","family":"Xu","sequence":"first","affiliation":[{"name":"Lanzhou University","place":["Lanzhou, Gansu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linru","family":"Yang","sequence":"additional","affiliation":[{"name":"Gansu University of Chinese Medicine","place":["Lanzhou, Gansu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lanzhou University","place":["Lanzhou, Gansu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingliang","family":"Hu","sequence":"additional","affiliation":[{"name":"Zhangxian People\u2019s Hospital","place":["Dingxi, Gansu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Chengxian People\u2019s Hospital","place":["Longnan, Gansu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Gansu Provincial People\u2019s Hospital","place":["Lanzhou, Gansu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxu","family":"Da","sequence":"additional","affiliation":[{"name":"Gansu Provincial People\u2019s Hospital","place":["Lanzhou, Gansu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0035","article-title":"Soft tissue sarcoma, version 2.2022, NCCN clinical practice guidelines in oncology","volume":"20","author":"von Mehren","year":"2022","journal-title":"J Natl Compr Canc Netw"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/7594027","article-title":"Diagnosis and prognosis of retroperitoneal liposarcoma: a single Asian center cohort of 57 cases","volume":"2021","author":"Xiao","year":"2021","journal-title":"J Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.25259\/cytojournal_246_2024","article-title":"Clinicopathological and molecular diagnosticfeatures of liposarcoma: a study of 27 cases","volume":"22","author":"Zhu","year":"2025","journal-title":"Cytojournal"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1528","article-title":"Giant retroperitoneal liposarcoma: correlation between size and risk for recurrence","volume":"13","author":"Marjiyeh-Awwad","year":"2022","journal-title":"World J Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s12957-020-02069-2","article-title":"Perioperative strategy and outcome in giant retroperitoneal dedifferentiated liposarcoma-results of a retrospective cohort study","volume":"18","author":"Bachmann","year":"2020","journal-title":"World J Surg Oncol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12894-023-01252-3","article-title":"Recurrent metastatic retroperitoneal dedifferentiated liposarcoma: a case report and literature review","volume":"23","author":"Liao","year":"2023","journal-title":"BMC Urol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-09916-2","article-title":"Diagnostic accuracy of CT and MR features for detecting atypical lipomatous tumors and Malignant liposarcomas: a systematic review and meta-analysis","volume":"33","author":"Wilson","year":"2023","journal-title":"Eur Radiol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-023-02731-8","article-title":"Multivisceral resection for retroperitoneal liposarcoma-is it worth it? A 20-year single-center experience","volume":"53","author":"Teixeira","year":"2023","journal-title":"Surg Today"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(20)30446-0","article-title":"Preoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial","volume":"21","author":"Bonvalot","year":"2020","journal-title":"Lancet Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(16)30050-x","article-title":"Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database","volume":"17","author":"Nussbaum","year":"2016","journal-title":"Lancet Oncol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.891710","article-title":"A systematic review of margin status in retroperitoneal liposarcomas: does the R0 margin matter","volume":"12","author":"Paik","year":"2022","journal-title":"Front Oncol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1529755","article-title":"Challenges and hope: latest research trends in the clinical treatment and prognosis of liposarcoma","volume":"16","author":"Liu","year":"2025","journal-title":"Front Pharmacol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1186\/s12885-025-13813-w","article-title":"Clinical course and prognostic factors of patients with dedifferentiated liposarcoma: a retrospective analysis","volume":"25","author":"Casier","year":"2025","journal-title":"BMC Cancer"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/jso.28155","article-title":"Neoadjuvant immunotherapy for resectable dedifferentiated liposarcoma: a national cohort analysis","author":"Farooq","year":"2025","journal-title":"J Surg Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1751424\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:37:02Z","timestamp":1776832622000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1751424\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":14,"alternative-id":["10.3389\/fonc.2026.1751424"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1751424","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"article-number":"1751424"}}